Research works

Cervical cancer prevention and control strategy in Ethiopia: key informant clinicians’ perspective

Abstract Background: Cervical cancer is a major public health burden in Ethiopia, ranking second among women and disproportionately affecting HIV-positive individuals. In 2020, an estimated 7,445 new cases and 5,338 deaths occurred. Thus, accurate diagnosis, treatment, and pallia...

Conformational asymmetry of replicated human chromosomes

Abstract DNA replication creates two sister chromatids that must acquire specific three-dimensional conformations to support genome function and stability. This organization is largely mediated by cohesin complexes, which extrude intra-chromosomal loops and link two chromatids, t...

Floquetifying stabiliser codes with distance-preserving rewrites

Stabiliser codes with large weight measurements can be challenging to implement fault-tolerantly. To overcome this, we propose a Floquetification procedure which, given a stabiliser code, synthesises a novel Floquet code that only uses single- and two-qubit operations. Moreover,...

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

Abstract Cryogenic electron microscopy (cryo-EM) made impressive progress in resolving cellular macromolecules and their detailed interactions. Single-particle cryo-EM traditionally relies on purified macromolecules and lacks the complexity of cellular environments, whereas in si...

Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex

Animals can solve new, complex tasks by reusing and adapting what they've learned before. This kind of flexibility depends not just on having prior experience, but on how that experience was structured in the first place. The design of early training curriculum is especially impo...

Longitudinal evidence for decreasing statistical learning abilities across childhood

Abstract Statistical learning enables us to identify patterns in our environment and predict future events, thereby supporting a range of motor, cognitive, and linguistic skills. Despite its significance, the developmental trajectory of statistical learning has remained unclear d...

Ensemble clustering: A practical tutorial

Abstract Cluster analysis is an explorative analytical method, serving as a critical tool in psychology, psychiatry, and related fields to map heterogeneous data into meaningful subgroups. Despite their extensive historical use, traditional clustering techniques suffer from a lac...

Non-standard proteins in the lens of AlphaFold 3: a case study of amyloids

Abstract While three-dimensional structures of globular and transmembrane forms are available for many amyloid proteins, structures of their amyloid forms are scarce in the PDB. Amyloids pose major challenges for both experimental structure determination and computational modelli...

ntSynt-viz: Visualizing synteny patterns across multiple genomes

Abstract With the explosion of chromosome-scale genome assemblies being generated in recent years, there is vast potential for comparative genomics analyses through detecting multi-genome synteny. While existing tools can detect synteny blocks between multiple genomes, their text...

Egyptology and Social Media: the YouTube Experience Initiative

Ancient Egypt, and Egyptology by extension, have long been popular subjects and field of study. Exhibitions, documentaries, books, artistic productions… Whenever Ancient Egypt is presented, the general public is drawn to it, or at least intrigued by it. From a more positive persp...

KEFE P: Possibility and Physical Realization - Typed candidates, accessibility, ordered history, and source ownership

Abstract KEFE P defines the typed bridge between possible structural continuations and physically realized events within the KEFE Foundation suite. It separates candidate generation, relational admissibility, physical fit, selection, and source-owned realization while establishin...

AA REVIEW ARTICLE: ROLE OF SWARNAPRASHAN IN IMPROVING IMMUNITY AND PREVENTING RECURRENT UPPER RESPIRATORY TRACT INFECTIONS (URTI) IN CHILDREN

Recurrent upper respiratory tract infections (URTI) rank among the most prevalent causes of illness in children, particularly those aged 1 to 15 years. Factors such as immature immune systems, environmental influences, and nutritional aspects lead to frequent occurrences of infec...

VIRUDDHA AHARA: A परमख करण OF VYADHI IN AYURVEDA

Viruddha Ahara is an important dietary concept described in Ayurveda, which refers to incompatible food combinations, improper food processing, wrong food timing, unsuitable quantity, and diet taken against individual constitution or season. Ayurveda considers food as the main su...

THE 'SING-LISH' PROJECT: ITS IMPLICATIONS ON GRADE FOUR PUPILS' SPEAKING ABILITY IN ENGLISH AND LEARNING OUTCOMES

This descriptive study explored the implications of the ‘SING-LISH’ project on Grade 4 pupils’ speaking ability in English and learning outcomes. ‘SING-LISH’, a pioneer and experimental project embarked in Bangkok, Thailand uses English songs for pupils to learn the English langu...

IMPACT OF PATIENT COUNSELLING ON CLINICAL OUTCOMES AND MEDICATION ADHERENCE IN PATIENTS WITH NON-COMMUNICABLE DISEASES IN A TERTIARY CARE HOSPITAL: A REVIEW

Globally, non-communicable diseases (NCDs) include cancer, chronic renal disease, diabetes mellitus, heart disease, and chronic respiratory conditions are the leading causes of morbidity and mortality. Due to long-term treatment needs, growing healthcare expenditures, and decreas...

INTEGRATIVE RESEARCH IN VATAJA PRAMEHA

Vātaja Prameha, one of the twenty subtypes of Prameha described in Ayurveda, is characterized by predominance of Vāta dosha along with Meda and Kleda vitiation in Mutravaha Srotas. It often presents as a chronic and debilitating stage of the disease, associated with severe tissue...

DESIGN AND DEVELOPMENT OF AN END-TO-END PREDICTIVE MODELING SYSTEM TO TURN MESSY RAW DATA INTO SOLID PREDICTIONS

This paper presents a Predictive Modeling System. In real world, the data is raw which means some of the data is missing, data is not structured etc. So the predictions we make are manual and not correct. Without the clean data we make wrong predictions that lead to wrong outcome...

EBOLA VIRUS VACCINES AND RECENT ADVANCEMENTS: A SCOPING REVIEW

Background: Ebola virus disease (EVD), caused by Orthoebolavirus species, is a severe and often fatal viral haemorrhagic disease with an average case-fatality rate of approximately 50%. The 2014–2016 West African epidemic accelerated vaccine development, leading to the licensure...

Hybrid 5D Gravity (H5DG): A Step Towards Unification

Hybrid 5D Gravity (H5DG) is a fourteen-paper theory of gravity and gravitational unification that investigates whether a deliberately constrained five-dimensional braneworld can connect relativistic gravity, galactic dynamics, gravitational lensing, a collisionless dark sector, p...

DIFFERENTIATED APPROACH TO THE DIAGNOSIS AND TREATMENT OF MONOSYMPTOMATIC NOCTURNAL ENURESIS IN CHILDREN

Background: Monosymptomatic nocturnal enuresis (MNE) is a common developmental disorder characterized by intermittent urinary incontinence during sleep in children aged five years or older in the absence of clinically relevant daytime lower urinary tract symptoms. Although sponta...