Research works

Capturing regional variation in aortic mechanics: dual-estimation method for material parameter identification and biological correlation

Abstract The aorta shows significant regional variation in geometry and composition. This complexity makes numerical modeling challenging, as it requires identifying material parameters. Typically, the Holzapfel-Gasser-Ogden model is used. However, it suffers from nonuniqueness a...

On the Emergence of Kerr-Schild Geometry from Coherent Weyl Spinor Currents

We analyse the conditions under which a Kerr–Schild metric structure [Formula: see text] emerges from a spacetime framework sourced by fermionic spin currents. The symmetric metric perturbation decomposes into an isotropic sector [Formula: see text] and an anisotropic sector [For...

Quantum Chemical Microsolvation via Free Energy–Based Solvation Site Identification

Abstract In quantum chemical descriptions of solutions, solvents are treated either implicitly, accounting only for bulk properties, or explicitly by including solvent molecules in the calculations. Although explicit treatments are more accurate, they are often computationally pr...

Criticality Quenching and Microstructure of Quintessence-AdS Black Holes

In this work, we investigate the thermodynamic criticality and Ruppeiner geometry of four-dimensional Reissner-Nordström Anti-de Sitter (RN-AdS) black holes surrounded by quintessence, with particular emphasis on the grand canonical ensemble at fixed electric potential. We first...

Common variant contributions to neurodevelopmental risk in orofacial clefts

Abstract Background Children with cleft lip and/or palate (CL/P) experience increased rates of neurodevelopmental difficulties, including ADHD, autism spectrum disorder, and educational challenges. While rare neurodevelopmental copy number variants (ND-CNVs) are enriched in this...

Inhibition of oxytocin neurons during key periods of development has long-term behavioral and body composition effects

Abstract Background: Oxytocin (OT) is a key neuromodulator of social behavior in mammals, and accumulating evidence supports the existence of a critical period for OT action during infancy. However, other developmental windows remain poorly explored, and it remains unclear whethe...

Measuring and modelling the structural dynamics of poricidal anthers: a mechatronic approach

The mechanical dynamics of poricidal stamens play a crucial role in buzz pollination, but they have only been studied in a few species showing comparatively less curvature. This paper presents an integrated experimental-computational approach to characterize the dynamic behaviour...

Exploring the transcriptional crosstalk between adipose tissue and locoregional recurrence in breast cancer using independent component analysis

Locoregional recurrence (LRR) poses a persistent clinical challenge in breast cancer, with emerging evidence implicating the tumor-associated adipose tissue in modulating recurrence risk. This study investigates shared transcriptional programs between adipose tissue and breast tu...

Bayesian inference of gene regulatory networks at stochastic steady state

Gene Regulatory Networks (GRNs) form the regulatory backbone that coordinates gene expression. The architecture of GRNs shapes their function and constraints the biochemical pathways through which information flows. Inferring the structure of regulatory interactions is thus essen...

Age-related changes in the gut microbiota of a long-lived seabird suggest divergence from mammalian models

Abstract Gut microbiota plays key roles in shaping host development, immunity, and physiology. The assembly of vertebrate gut microbiota during early life follows relatively predictable trajectories across several mammalian species, largely driven by maternal transmission routes....

Noncarbohydrate Inhibitors of Sialic Acid-Binding Immunomodulatory-Type Lectin-7 (Siglec-7) Discovered from Genetically Encoded Bicyclic Peptide Libraries

ABSTRACT Glycan-binding proteins (GBP) are among the most difficult to drug targets. This deficiency delays clinical progress for therapeutically important GBPs. We employed bicyclic genetically encoded libraries (BiGELs), produced by chemical modification of phage-displayed libr...

Extensions of unirational groups

Abstract We undertake a study of extensions of unirational algebraic groups. We prove that extensions of unirational groups are also unirational over fields of degree of imperfection 1, but that this fails over every field of higher degree of imperfection, answering a question of...

Impact of LLM assistance on physician decision-making: a multi-country randomized controlled trial

Abstract Disparities in the quality of healthcare persist globally, with poor-quality care contributing significantly to preventable mortality, particularly in low- and middle-income countries. While digital technologies, including generative artificial intelligence (AI), hold pr...

Untangling the effects of within-host and between-host natural selection in viruses with applications to evolution of HIV-1 co-receptor usage

Abstract The fitness of a pathogen can be characterised at multiple levels corresponding to different stages of its life cycle, including replication within target cells (replicative capacity), immune evasion, and the capacity to infect new hosts (transmissibility). Pathogens evo...

Deliberate prehistoric sourcing of the Devil's Arrows, Britain's tallest stone row

Abstract How prehistoric societies selected and transported megaliths remains poorly understood because the geological sources of many monuments are unresolved. The approximately 7 m tall and 25-tonne Devil's Arrows are Britain's tallest surviving standing stone alignment, yet th...

End processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis

Non-homologous end joining (NHEJ) is a major pathway of DNA double strand break (DSB) repair, capable of directly joining both damaged strands of DNA through the coordinated activities of repair factors that detect the termini, physically bridge them together, and perform the che...

A Unified Taxonomy and Design Space for Efficient and Verifiable Blockchain Querying: A Systematic Literature Review

International audience

Training to Protect Research Integrity in the Age of AI-assisted Coding

Poster presented at the 10th Research Software Engineering Conference (RSECon26) in Sheffield, UK, 9-11 September, 2026. Abstract The use of generative AI tools to generate source code or to augment a programmer's own code is ever more widespread in research software development....

Training to Protect Research Integrity in the Age of AI-assisted Coding

Poster presented at the 10th Research Software Engineering Conference (RSECon26) in Sheffield, UK, 9-11 September, 2026. Abstract The use of generative AI tools to generate source code or to augment a programmer's own code is ever more widespread in research software development....

Training to Protect Research Integrity in the Age of AI-assisted Coding

Poster presented at the 10th Research Software Engineering Conference (RSECon26) in Sheffield, UK, 9-11 September, 2026. Abstract The use of generative AI tools to generate source code or to augment a programmer's own code is ever more widespread in research software development....