Research works

Poison exon splicing in the human brain provides a new paradigm for understanding and targeting neurological disorders

Poison exons are highly conserved exons whose inclusion creates premature termination codons and triggers nonsense-mediated decay (NMD) of the mature transcript. Despite their important role in post-transcriptional regulation, poison exons remain poorly annotated due to the lack...

Coordination‐Asymmetry‐Regulated Reconstruction of Electron‐Rich Cu Sites for pH‐Dependent Nitrate‐to‐Ammonia Electrocatalysis

ABSTRACT Electrocatalytic nitrate reduction reaction ( e‐ NO 3 RR) offers a promising route to valorize nitrate‐contaminated wastewater while enabling sustainable ammonia production; however, how local coordination asymmetry regulates Cu‐site evolution and reaction pathways acros...

Are Petrea volubilis and P. arborea (Verbenaceae) Conspecific? New Insights From Anatomy

ABSTRACT Correct taxonomic identity is crucial in plant taxonomy, especially in the case of practically good species that are considered conspecific due to lack of sufficient reliable data, such as those studied here. Linnaeus in 1753 established the genus Petrea L. with a single...

The genome sequence of the banded centipede, Lithobius variegatus Leach, 1814

We present a genome assembly from a female specimen of Lithobius variegatus (banded centipede; Arthropoda; Chilopoda; Lithobiomorpha; Lithobiidae). The assembly contains two haplotypes with total lengths of 1,766.49 megabases and 1,768.00 megabases. Most of haplotype 1 (97.68%) i...

Human motor and economic decisions show common risk-seeking bias under asymmetric gains

Abstract To plan actions optimally, it is essential to take one’s own variability into account. The outcome of an action is determined by the target of the action plan, the variability of the action, and the gain/loss function of the outcome. In previous studies, we demonstrated...

Small interfering RNA targeting protein Z-dependent protease inhibitor improves hemostasis in Von Willebrand factor- and Factor X-deficient mice

Non-factor therapeutics have transformed the treatment paradigm in hemophilia A. Owing to their mode of action, these agents may also provide benefit for other rare bleeding disorders (RBDs) such as von Willebrand disease (VWD)-type 3 and Factor X (FX) deficiency. Targeting prote...

Laparoscopic and Robotic Device Malfunction: A Scoping Review

Laparoscopic and robotic surgeries have become the gold standard for many operations. Device malfunctions during these procedures represent a preventable source of patient harm; however, the trends in malfunction reporting and their implications for surveillance systems, surgical...

GLP-1 receptor agonists and hair loss: adverse effect, epiphenomenon, or therapeutic paradox?

Abstract Objective Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual/triple agonists, have revolutionized the management of obesity and type 2 diabetes. However, hair loss has emerged as an adverse event in clinical practice. This...

Topology-aware dynamic co-evolution for robust graph learning

Graph Neural Networks (GNNs) have achieved remarkable success in learning from graph-structured data. However, recent studies have revealed their vulnerability to adversarial attacks, where imperceptible perturbations to the graph structure can easily mislead predictions. Existin...

Empirical Extraction of Bi-Fractal Metric Breathing via Multi-Messenger Neutrino and Photon Transit Residuals: Unifying Macro-Cosmological Curvature with Local Orbital Harmonics

We present empirical evidence demonstrating that local temporal coordinates and macrocosmologicalevolution are governed by a unified bi-fractal metric framework (Cμν). Utilizingmulti-year archival records of solar neutrino fluxes and photon irradiance (SOHO/VIRGOand Super-Kamioka...

Mechanochemically Controlled Functionalization of Graphene Microdrums

Abstract Mechanochemical reactions involve the use of applied mechanical distortions to reactants to drive chemical reactions. In this work, we demonstrate the use of mechanical force to direct location-specific reactions on suspended bilayer graphene microdrums, by manipulating...

Critical values, resultants and norms of the Chebyshev defect

For \(d\ge3\) let \(F_d(c)=c^d-T_d(c)\) and let \(C_d\) be its uniform norm on \([-1,1]\). We connect the critical geometry of this defect with a single cyclotomic resultant. The critical values at distinct positive critical points have distinct absolute values; a pair of monoton...

Alternative splicing fine-tunes modular protein interfaces to control protein localization

Abstract Alternative splicing provides a pervasive means to expand proteome complexity, yet how it reorganizes protein interactions and cellular localization remains unclear. Here, we show that tissue-regulated longer exons preferably reshape local interaction patterns, whereas m...

Visible-Light-Driven C–F Bond Cleavage in Perfluoroalkyl Carboxylic Acids: Readily Accessible Ruthenium-Bipyridine Complexes as Effective Catalysts

Abstract Herein, we report the reaction discovery and mechanistic studies of a visible-light-driven defluorination reaction of perfluoroalkyl carboxylic acids (PFCAs), a major class of perfluoroalkyl substances (PFAS) widely present in the environment that pose significant health...

Semantic Segmentation of Brain Tumor MRI Images Using ResUNet, ResNet-50, and DenseNet121: A Comparative Study

Brain tumor segmentation from Magnetic Resonance Imaging (MRI) is an important task in tumor analysis, treatment planning, and disease monitoring. However, manual delineation of tumor regions is time-consuming, subjective, and prone to inter-observer variability. This study prese...

Visual Search Behavior Towards Reference Areas During an S-Curve Driving Task in Elderly Drivers with Mild Cognitive Impairment

Age- and cognitive-related changes in visual search behavior may affect driving performance, particularly during complex road maneuvers requiring continuous steering adjustments. The aim of this study was to clarify the characteristics of visual search behavior in elderly drivers...

Immunohistochemical Insights into Enhanced Burn Wound Healing by Poly(vinyl alcohol)/Gentamicin and Poly(vinyl alcohol)/Chitosan/Gentamicin Hydrogels

Novel poly (vinyl alcohol) (PVA)/gentamicin (Gent) and PVA/chitosan (CHI)/Gent hydrogels have previously demonstrated improved burn wound healing in a rat model, based on clinical assessment and histological analysis. This study aims to provide immunohistochemical insight into th...

Lignin Degradation Potential of Novel Streptomyces Isolates from the Juniperus turcomanica Rhizosphere via Broad-Spectrum Enzymatic Activities

This study provides a comprehensive characterization of Streptomyces isolates associated with the rhizosphere of the centenarian Juniperus turcomanica. Screening for ligninolytic activity revealed that isolates—ATM9, ATM14, ATM15, ATM16, ATM18, and ATM19 synthesize enzymes capabl...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Influence of Rotational Effects on Droplet Trajectories and Sprinkler Spray Uniformity

A three-dimensional droplet motion model considering the rotational effect of the sprinkler tray was established in a fixed reference frame for low-pressure rotary sprinklers to reveal the effects of tray rotation of a rotary sprinkler on the flight trajectories of water droplets...