Research works

Structure, Intelligibility, Inquiry: A Unified Metaphysical Basis for Science

This paper belongs to the ARM systemic series, a unified metaphysical system that begins with agápēic relational actuality as its primitive and derives the modal architecture of reality from that starting point. Earlier papers established non‑coercive distinction, determinate rel...

A numerical investigation on ultimate strength of marine sandwich composites under combined biaxial compression and lateral pressure

With the development of large-scale and light-weight ships, sandwich composites are increasingly used in hull structures because of their advantages of light weight, excellent mechanical properties, and corrosion resistance. Due to the synergistic effect among materials, sandwich...

LinkLlama: Enablinga Large Language Model for ChemicallyReasonable Linker Design

Fragment-based drug discovery (FBDD) relies heavily on the design of chemically viable linkers to connect fragments binding to different pocket regions into potent lead molecules. While recent generative models have advanced spatial fragment linking, they frequently produce linke...

Quantum Laws of Form: A Syntactic Foundation for Physics: From The Calculus of Distinction to Ultrametric Cosmology

Quantum information is not intrinsically fragile; we have been measuring it incorrectly. This monograph presents a radical re‑foundation of physics based on George Spencer‑Brown’s Laws of Form, strictly adhered to and extended into a Syntactic Token Calculus (STC). The framework...

“A comparison of pre-operative urine culture with intra-operative stone culture and its association with post-procedural sepsis: a prospective observational study”

<title>Abstract</title> <bold>Background and Aim:</bold> Urosepsis is a dreaded complication following endourological procedures. Urinary calculi are known to harbour bacteria that may be released into the circulation during fragmentation, potentially leading to urosepsis. Thus,...

The Portrayal of Libraries as Remote Workplaces in the General Media: A Qualitative Content Analysis

A sample of 52 sources were analyzed to investigate how libraries are portrayed in the general media as spaces for remote workers. Features highlighted as advantageous included meeting rooms, booths, quiet zones, and on-site cafes; Wi-Fi, computers, reprographic services, and sui...

Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

<title>Abstract</title> <bold>Purpose</bold> Methylprednisolone is commonly used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and procedural factors such as ci...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Youth participation coach learning: A scoping review

Coaching in the youth participation sport domain has garnered considerable attention amongst researchers, sport development organisations and coach education bodies over the last decade. However, little is empirically known of how youth participation sport coaches learn and how t...

Antibacterial characteristics of black currant fruit extracts

<title>Abstract</title> <bold>Background</bold> : Our group previously reported from high bactericidal potential of berry juices, especially from blackcurrant fruits. The present study observed different fractions from blackcurrant fruits (all-fruit juice: AFJ, squeezed juice: SJ...

Optimization of Manufacturing Processes Using AI-Based Advisory Systems: Casting Application

Artificial Intelligence (AI) and its subset, Machine Learning (ML), play transformative roles in the manufacturing sector, forming the foundation of the “Industry 4.0 and 5.0” frameworks. This research contributes to that evolution by developing AI-based advisory systems that uti...

Number Theory as Physics: The Prime-Coded Universe: How Scaling Ratios, Not Numbers, Generate Continuous Reality from Discrete Foundations

Human perception of continuous space and time is not a window onto fundamental reality but an evolutionary adaptation. Mammalian sensory systems—particularly vision, touch, and proprioception—evolved to represent the world as continuous because this representation conferred survi...

O*NET Task→Ability Mapping Dataset

A task-level mapping from 18,796 O*NET work tasks, spanning all 23 SOC major groups, to the 52 O*NET human abilities each task requires, with a graded importance weight per (task, ability) pair. The dataset contains 95,330 task-to-ability mappings. Labels were generated with a la...

Does cooperation pay off over time? Evidence from water and wastewater services

Local governments around the world adopt governance arrangements, including intermunicipal cooperation (IMC), as strategies to improve water and wastewater services (WWS). This study examines whether involvement in IMC is associated with improved performance of WWS providers. Per...

Performance of a novel double-sided irradiation receiver for next-generation solar power tower systems

In solar power tower systems, conventional cylindrical receivers suffer from severe circumferential temperature non-uniformity and excessive thermal stress due to single-sided irradiation. To address these issues, this study proposes a novel double-sided irradiation receiver conc...

Protein LanguageModel Decoys for Target Decoy Competitionin Proteomics: Quality Assessment and Benchmarks

Abstract Large-scale proteomics relies heavily on target–decoy competition for false discovery rate estimation in peptide identification, and the performance of this strategy depends strongly on the design of the decoy database. Classical generators such as reversal and shuffling...

Poromechanical toughening in tensile fracture of saturated solids

<title>Abstract</title> Fracture in fluid-saturated porous solids is governed not only by solid mechanics but also by fluid flow within the pore space. In systems ranging from geomaterials to biological tissues, deformation in the near-tip region perturbs pore pressure and thereb...

Quasinormal modes and AdS/CFT correspondence of a rotating BTZ-like black hole in the Einstein-bumblebee gravity

Abstract We obtain exact expressions for the quasinormal modes (QNMs) of the massive scalar, fermionic and vector perturbations around a rotating BTZ-like black hole in the Einstein-bumblebee gravity. We find that the Lorentz symmetry breaking (LSB) parameter $$\ell $$ <mml:math...

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2

Upstream open reading frames (uORFs) within the 5’-untranslated region (5’-UTR) of mRNA transcripts can regulate protein translation. Despite widespread prevalence within the human genome, they remain unidentified for many clinically relevant genes. A gene frequently associated w...

Critical impact of thermal management systems on on-board systems in hydrogen-powered aircraft

<title>Abstract</title> Hydrogen-powered aircraft offer a promising pathway to reduce the aviation sector's climate impact, with fuel cells providing high-efficiency power conversion at around 50%. However, producing considerable waste heat at around 80°C. Since this heat is gene...