Research works

Design, Synthesis,and Evaluation of Alkoxyamine AnticancerProdrugs Bearing Galactoside as an Enzyme-Activated Trigger

Abstract Enzyme-induced cytotoxicity can be considered the main challenge in modern cancer therapy that provides unique opportunities for targeted apoptosis. To address this challenge, we implemented enzyme-triggered activation of alkoxyamine–galactose conjugates with the formati...

Associations of beans, bean products, and soy isoflavone intake with chronic kidney disease: a cross-sectional study

Abstract Background Current evidence on the association between beans and bean products intake and chronic kidney disease (CKD) remains limited. In vitro and animal studies suggest that soy isoflavones exhibit antioxidant and anti-inflammatory properties, potentially conferring r...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

“I Wasn’t Alone in How I Am”: Psychological Inquiry Into Players’ Experiences With Queer Representation in Gone Home

While there has been an explosion of research around the psychological dynamics of video game play, comparatively little work has been to explore the many divergent approaches video games take to create identification and connection within it’s players, especially around LGBTQ+ r...

Finite Partition-Function Curvatures

Let $Z(\beta)=\sum_{j=1}^{m}g_j e^{-\beta e_j},\qquad$ $0<g_j,\quad e_1<\cdots<e_m,$ be a primitive finite weighted canonical partition function, and let \(K=(\log Z)''\) be its log-partition curvature. Physically, \(K\) is the canonical energy variance and satisfies \(C_V=k_B\be...

Assessing acuity in pediatric emergency department triage: performance of a large language model

Pediatric triage performance varies across emergency departments (ED), contributing to ongoing challenges in pediatric emergency care. There is growing interest in using large language models (LLMs) to support more consistent triage decision-making in children. We evaluated an LL...

The Role ofPolyQ in Global Conformational Dynamicsand Stability of Huntingtin

Abstract Huntington’s disease (HD) is known for its abnormal polyQ stretch in the first exon of the HTT gene. HD is listed among the fatal autosomal dominant neurodegenerative disorders targeting the central nervous system and interfering with motor, cognitive, and psychiatric fu...

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Abstract Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, the precise m...

The Garden That Left No Trace: Virtual Reconstruction at the Evidential Minimum — a Conjectural Renaissance Kitchen Garden for Burg Schönebeck

Gardens are the most perishable class of built heritage. A demolished building leaves foundations, fragments, andusually documents; a garden leaves soil. When the garden in question was a working kitchen garden at a minorWestphalian castle — never painted, never engraved, never d...

Extracellular Matrix-InspiredElectrospun Nanofiber-Coated3D-Printed Polylactic Acid Scaffolds for Bone Regeneration

Abstract Three dimensional (3D)-printed polylactic acid (PLA) scaffolds have gained significant attention for bone tissue regeneration due to their excellent biocompatibility, tunable architecture, and mechanical strength. However, the hydrophobic and bioinert surface of PLA limi...

Auricular Neurostimulation: A Novel Therapy for Abdominal Pain-Related Disorders of Gut-Brain Interaction

Disorders of gut-brain interaction (DGBI) are highly prevalent in the pediatric population. DGBI are heterogeneous disorders with presumed multifactorial pathophysiology. Emerging studies document autonomic nervous system alterations in at least a subset. There is significant sym...

Weight status, percent body fat, eating habits, depression, and food addiction in Palestinian university students: a cross-sectional study

Abstract Background Obesity and excess adiposity among university students are important public health concerns. This study aimed to determine the prevalence of overweight and obesity among Al-Quds University students using both body mass index (BMI) and percent body fat (PBF), a...

Trace element accumulation in bryophytes from Allchar (North Macedonia): contamination or genuine hyperaccumulation?

Abstract Main conclusion Genuine accumulation of metals/metalloids in bryophytes is limited and highly susceptible to surficial contamination with soil particles. Washing with an apolar solvent removes most surficial contamination prior to elemental analysis. Abstract Bryophytes...

Labor Market Impact Disaggregation: Which Knowledge Work Tasks Are Actually Automated by LLMs

Research article: Labor Market Impact Disaggregation: Which Knowledge Work Tasks Are Actually Automated by LLMs

Diabetes mellitus and risk of injury requiring medical care: a nationwide population-based matched cohort study in Taiwan

Abstract Background Diabetes mellitus (DM) is associated with multiple microvascular and macrovascular complications; however, its association with clinically significant injury requiring medical care remains incompletely understood. This study aimed to investigate the associatio...

Emphysematous Pyelonephritis Masquerading as Diabetic Ketoacidosis: A Case Report

Emphysematous pyelonephritis (EPN) is a rare, fulminant, gas-forming necrotising infection of the renal parenchyma and surrounding tissue that occurs almost exclusively in patients with diabetes mellitus and carries substantial morbidity and mortality if not recognised promptly....

From gamification to work performance: a two-wave, two-study examination of psychological needs and meaningful work of employees in China and Singapore

Purpose Organisations are increasingly adopting gamification as a strategy to enhance employee motivation, engagement, and performance. While prior research has primarily examined gamification as an organisational tool, this study shifts the focus to how employees experience gami...

IRI Estimation across Varying Point Densities in LiDAR-Derived Point Clouds: Effects of Profile Extraction and Transformer-Based Classification

Abstract The international roughness index (IRI) is a widely adopted metric for quantifying road surface irregularities and assessing pavement ride quality. Traditional IRI estimation methods have relied on vehicle-mounted inertial profilers that collect data along wheel paths. W...

Logistics service quality and repurchase intention: investigating the mediating role of website brand image

Abstract The main purpose of this research is to examine the extent to which logistics service quality shapes consumers’ repurchase intentions in the context of online shopping, as well as to explore the mediating function of website brand image within this relationship. To addre...

Generation of a senescent synovial organoid model using rat synovial fibroblasts treated with oxidative stress

Abstract Background Osteoarthritis (OA) is a common age-related joint disease characterized by cartilage loss and synovitis. Cellular senescence contributes to chronic inflammation through senescence-associated secretory phenotypes (SASPs). Recent evidence indicates that senescen...