Research works

MARLOWE: taxonomic characterization of unknown samples for forensics using de novo peptide identification

Abstract We present a computational tool, MARLOWE, for source organism characterization of unknown, forensic biological samples. The intent of MARLOWE is to address a gap in applying proteomics data analysis to forensic applications. MARLOWE produces a list of potential source or...

Accelerating protein design by scaling experimental characterization

Abstract Recent advances in de novo protein design have greatly outpaced standard protein biochemistry workflows, and experimental testing has been a bottleneck in the validation of new designs and methodologies. Here, we describe experimental and computational workflows to addre...

NEXUS Personalized Health, One platform to make your biomedical research possible

We are NEXUS Personalized Health at the ETH Zurich. Our friends call us NEXUS. We offer highly customizable services and collaborations in the field of biomedical research and development. A pool of professional scientists in bioinformatics, data science, statistics, software eng...

NEXUS Personalized Health, One platform to make your biomedical research possible

We are NEXUS Personalized Health at the ETH Zurich. Our friends call us NEXUS. We offer highly customizable services and collaborations in the field of biomedical research and development. A pool of professional scientists in bioinformatics, data science, statistics, software eng...

Tetrahydrocurcumin ameliorates depression-like behaviors in chronic restraint stress mice by modulating neuroinflammation and neurotrophic balance via the SIRT1/NF-κB pathway.

OBJECTIVES: the SIRT1/NF‑κB pathway. METHODS: experiment, BV2 microglial cells were stimulated with lipopolysaccharide (LPS) and treated with THC with or without the SIRT1 inhibitor EX-527 for validating the pathway mediating the effect of THC. RESULTS: cells and increased SIRT1...

SPN 313: Advanced Communication Skills

This syllabus for SPN 313 (Advanced Communication Skills) at the College of Staten Island, CUNY, presents a zero-textbook-cost, OER-based course in advanced academic writing in Spanish designed for a mixed population of heritage speakers and advanced second-language learners. The...

The Missing Link in ERP Customization

Enterprise Resource Planning (ERP) systems provide organizational stability but often lack the flexibility needed for specific process adaptations. While Low-Code platforms (LCP) enable domain experts to design extensions, the integration of business process libraries (BPLs) with...

The Physicality of Scales: An Emergent Hierarchy from Minimal Axioms in Quantum-Geometry Dynamics

This paper proposes physically grounded definitions of object and scale within the framework of Quantum-Geometry Dynamics (QGD) and the Minimal Physically Derivable Theories (MPDT) programme established by the Uniqueness Theorem. Both definitions have been absent from the existin...

Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s

This article examines Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s with a focused emphasis on Uganda within the field of Law. It is structured as a conference paper that organises the problem, the strongest verified sc...

Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s

This article examines Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s with a focused emphasis on Uganda within the field of Law. It is structured as a conference paper that organises the problem, the strongest verified sc...

A Theoretical Framework for Sustainable Enterprise Governance in the Cape Verdean Archipelago, 2020–2026

The unique archipelagic context of Cape Verde presents distinct challenges and opportunities for sustainable enterprise governance, which remain under-theorised in the African behavioural finance literature. Existing frameworks often fail to account for the interplay between smal...

A Theoretical Framework for Sustainable Enterprise Governance in the Cape Verdean Archipelago, 2020–2026

The unique archipelagic context of Cape Verde presents distinct challenges and opportunities for sustainable enterprise governance, which remain under-theorised in the African behavioural finance literature. Existing frameworks often fail to account for the interplay between smal...

Mapping links between childhood maltreatment and biopsychosocial health in pregnancy: a network analysis

Abstract Purpose Child maltreatment experiences may impact both mental and physical health in pregnancy and are associated with increased interpersonal difficulties. However, facets of psychosocial and physical health are interrelated, making it difficult to identify effects of m...

Patterns of communication technology use in routine palliative care: a cross-sectional survey

Abstract Background Communication is central to palliative care, spanning patients, family caregivers, and institutions across diverse care situations. Digital technologies are increasingly discussed as a means of supporting palliative care delivery, yet quantitative evidence on...

Deep Cavitand Mediated Selective Aerobic Oxidative Cyclization of Thiols to Cyclic Disulfides

Abstract A mild supramolecular template strategy is reported for the selective synthesis of medium- to macrocyclic disulfides via aerobic oxidative cyclization of α,ω-dithiols in aqueous media. The water-soluble deep cavitand CV-1 serves as a multifunctional platform that synergi...

The chemical composition of narwhal tusk and tooth is impacted by geographical locality

Abstract The possible relationship between diet and geographical locality is important for understanding the putative effects of climate change on animal behaviour and survival. Narwhals have two maxillary teeth, one of which may become a tusk. In these teeth, various chemical el...

Effect of peripheral neuropathy on Achilles tendon: ultrasonographic study

Abstract Introduction Type 2 diabetes mellitus (T2DM) is frequently associated with diabetic peripheral neuropathy (DPN) and musculoskeletal complications, including Achilles tendon abnormalities. Limited evidence exists regarding if tendon abnormalities progress with increasing...

Costs and benefits of group size for sperm whales of the open ocean

Abstract Individual feeding success can change with the size of a social group through competition, cooperation, recruitment and other processes. Female sperm whales (Physeter macrocephalus) live in long-term social units that themselves can form larger, temporary groups, but the...

Unveiling the role of BrREM1.4: a key regulator in plant growth and abiotic stress adaptation in turnip (Brassica rapa)

Remorins (REMs) are plant-specific proteins known for their diverse biological functions. However, their roles in plant growth, development, and responses to abiotic stress remain largely unexplored. In this study, we investigated the function of BrREM1.4 (PQ810929), a protein is...

Reduced extinction risk for autotrophs in the open ocean

Abstract The marine plankton record offers a unique archive of deep-time ecological and evolutionary dynamics in the open ocean. With distinct biomineral compositions, trophic modes and other diverse ecological and geographic preferences, fossilized marine unicellular plankton gr...