Research works

A three-dimensional CFD–DEM model to investigate the fiber orientation and distribution during concrete extrusion in 3D printing

Abstract Steel fibers are a promising reinforcement for 3D concrete printing (3DcP), which enhance post-cracking mechanical strength and fracture resistance. However, during the printing process, fibers tend to align with the printing direction, which exacerbates the inherent ani...

Practical Scale-Up of Trickle Bed Continuous Hydrogenation for Pharmaceuticals

Abstract There is a growing trend in the pharmaceutical industry toward the adoption of continuous processing for the synthesis of active pharmaceutical ingredients (APIs) and intermediates. This enables access to novel synthetic routes by operating at high temperatures and high...

Impact of vibegron on quality of life in men with overactive bladder receiving treatment for benign prostatic hyperplasia: patient-reported outcomes from the randomized placebo-controlled COURAGE trial

Abstract Background Men receiving pharmacologic treatment for benign prostatic hyperplasia (BPH) may experience reduced quality of life (QoL) owing to persistent overactive bladder (OAB) symptoms. Vibegron, a β 3 -adrenergic receptor agonist, was approved for OAB symptoms based o...

Protocol for the ACTIVE trial: a multicentre, open-label, cluster-randomized controlled trial of a quality improvement programme for older adults with hip fracture in resource-limited hospitals in China

Aims The primary aim of the Action on Hip Fracture Management Quality Improvement (ACTIVE) trial is to evaluate whether a context-tailored quality improvement programme improves health-related quality of life at 120 days after hospital admission, among adults aged 65 years or old...

ENACT FCT Maps - September 2025 - February 2026

The ENACT FCT Maps 2026 (1) summarise the trends in the observations submitted to the ENACT structured knowledge base during the period September 2025 - February 2026. The maps are aligned to the four observatories of ENACT: Capabilities Observatory Technology Observatory Market...

Prevalence and associated factors of symptoms of depression, anxiety and stress in pregnant women in Mozambique: a cross-sectional study

Abstract Background Mental disorders represent a major public health burden worldwide, disproportionately affecting women in low- and middle-income countries. The perinatal period is a time of increased biological, psychological, and social vulnerability, heightening the risk of...

Zombie Memory: When Remembered Information Is Not Currently Authoritative

Long-running AI systems may retain information that remains true, relevant, or useful even after that information has lost current decision authority. This creates a problem that ordinary retrieval or final-answer accuracy may not capture: a model can know both the present state...

Data Has Its Own Ontology

Ontology has moved to the center of AI engineering and data architecture. Organizations increasingly encode customers, accounts, products, contracts, events, actions, and business rules as machine-readable objects and relationships. Semantic-layer architecture likewise places sha...

Atmospheric Production of Nostalgia: Walking Through Little Italy in New York City Between Mafia Landmarks and Italian Heritage

Abstract This article focuses on mafia-themed tours through Little Italy and Nolita in New York City to interrogate how they reproduce La Cosa Nostra’s, the Italian-American mafia, ongoing relevance. The study shows how this type of ‘dark tourism’ distils complex histories into m...

Carbonate-System Perturbation by Invasive Bivalves Threatens Drinking-Water Security in Calcium-Limited Catchments

Abstract Invasive bivalve ecosystem engineers pose an under-recognized threat to drinking-water security. In the Waikato River, New Zealand, rapid establishment of Corbicula fluminea (Asian clam) since their 2023 incursion has depleted dissolved calcium ∼24% below historical base...

Transformable Imidates Enabled Regiodivergent and Redox-Neutral C–H Amination That Tolerated Strongly Coordinating Heterocycles

Abstract The translation of C–H activation into practical platforms for bioactive molecule discovery remains constrained by poor functional group compatibility, limited scalability, and inefficient downstream diversification. Here we present a robust and scalable, redox-neutral C...

Assessment of solar organic rankine cycle systems for power generation in Nigeria

Abstract Nigeria has abundant solar energy, especially in the north, which is underexploited. The solar organic Rankine cycle (solar ORC) converts low- to medium-temperature heat sources into electricity or heat. This study analyses the deployment of solar ORC systems in Nigeria,...

PAX3 deficiency is associated with NLRP3-related inflammatory signaling and hearing loss in a mouse model of Waardenburg syndrome

Abstract PAX3 gene defects are a major cause of Waardenburg syndrome (WS), a genetic disorder characterized by pigmentation abnormalities and sensorineural hearing loss. However, the molecular mechanisms by which PAX3 deficiency contributes to hearing impairment remain incomplete...

Interleukin-17A regulates malignant T-cell proliferation via electron transport chain complex I

Abstract Cutaneous T-cell lymphoma (CTCL) is a rare malignancy of skin-resident T cells with clinically distinct subtypes characterized by an aberrant cytokine profile, notably elevated Interleukin-17A (IL-17A) levels. However, the functional importance of IL-17A dysregulation in...

Lane marking detection based on vertical noise mitigation modules

Abstract Accurate detection of lane markings is one of the primary tasks for Advanced Driver Assistance Systems (ADAS) and autonomous vehicles. State-of-the-art lane marking detection algorithms employ object-detection methods based on Convolutional Neural Networks (CNN) and have...

Transforming naval organizations in the digital age: leadership, AI and dynamic capabilities for change

Purpose Indonesia, with over 17,000 islands and one of the world's longest coastlines, faces escalating geopolitical dynamism, maritime tensions, and transnational threats such as narcotics trafficking, piracy and illegal fishing. As the principal naval defense force, the Indones...

Deep Learning for Polymer Informatics: A Critical Analysis of Representations, Architectures, and Evaluation Practices

Polymer science stands at a compelling intersection with deep learning, as computational methods increasingly complement experimental discovery by accelerating property prediction, inverse design, and process optimization. This review presents a critical and constructive synthesi...

Accelerating the development of bioelectronic medicine: overview and impact of the NIH Stimulating Peripheral Activity to Relieve Conditions (SPARC) initiative

Abstract The National Institutes of Health (NIH) Common Fund supports bold scientific programs that catalyze discovery across all biomedical and behavioral research to address high priority challenges for the NIH as a whole and make a broader impact in the scientific community. I...

Assessing the Availability and Nutritional Characterization of Browse Species as Camel Feed Resources in Borana Rangeland, Southern Oromia, Ethiopia

The study was conducted in Moyale and Yabello districts, which is situated in Borana zone of the Oromia Regional State. The objectives of this study was to assess the availability of major browse species used for camel feed resources and to characterize its nutritional value/chem...

Internal Marker Formation in a Recurrent Physical Process: A Constructive Existence Proof within a Finite Lumped Electrical Model Domain

This paper asks whether, within a restricted physical and methodological domain, a recurrent physical process whose first occurrence is externally initiated can generate a physical state that remains causally connected to a later state and, under fixed background conditions, is s...