Research works

To profit or not to profit? Evidence from Chile’s for-profit voucher schools

This note examines whether for-profit management affects educational outcomes in Chile’s voucher system. Using administrative panel data for all voucher-subsidised primary schools from 2010 to 2014, we compare for-profit and nonprofit schools in terms of inputs and student perfor...

Insights into the development and key factors of five European governance innovations for forest ecosystem service provision

Climate change and biodiversity loss necessitate the forestry sector to adapt its management practices to provide forest ecosystem services (FES) sustainably. However, there is a limited understanding of influences that foster novel governance approaches in forest management syst...

Development of a Targeted Choroidal Injury Model for the Study of Retinal Degenerations and Therapeutic Cell Replacement

Purpose: Choroidal loss is an important pathophysiological step in many retinal diseases, but few reliable translational models of choroidal injury exist. Here, we report a new targeted choroidal injury model using bioconjugated saporins and compare it models of systemic sodium i...

Differential associations between social determinants of health and the initiation of medications for opioid use disorder across care settings

Abstract Objective This study investigated associations between social determinants of health (SDoH) and time to MOUD initiation across care settings, providing insights for targeted interventions to promote equitable care for OUD patients. Material and Methods We linked patient-...

Discrete adjoint gradient computation for multiclass traffic flow models on road networks

Abstract This paper applies a discrete adjoint gradient computation method for a multi-class traffic flow model on road networks. Vehicle classes are characterized by their specific velocity functions, which depend on the total traffic density, resulting in a coupled hyperbolic s...

Existence of minimal surfaces in infinite-volume hyperbolic 3-manifolds

Abstract The existence of embedded minimal surfaces in non-compact 3-manifolds remains a largely unresolved and challenging problem in geometry. In this paper, we address several open cases regarding the existence of finite-area, embedded, complete, minimal surfaces in infinite-v...

Decarbonizing construction: a multi-level perspective analysis of green concrete transition in the Netherlands

Purpose The Netherlands is one of the frontrunners in green concrete with innovative pilot projects and institutional settings (e.g. concrete agreement). However, mainstreaming green concrete needs to further overcome economic, institutional, technical and social barriers. Especi...

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

Abstract Fragile X syndrome (FXS) is the principal monogenic syndrome leading to inherited intellectual disability and autism. It is caused by the silencing of FMR1 gene that leads to the loss in the expression of its encoded protein, the fragile X messenger ribonucleoprotein 1 (...

Equidistribution of orbits at polynomial times in rigid dynamical systems

We study the distribution of orbits sampled at polynomial times for uniquely ergodic topological dynamical systems ( X , T ) (X, T) . First, we prove that if there exists an increasing sequence ( q n ) (q_n) for which the rigidity condition \[ max t > q n + 1 4 / 5 sup x ∈ X d (...

Flow of power-law fluids in thin straight tubes of non-uniform cross-section

Abstract We analyze the asymptotic behavior of solutions to a boundary value problem describing the flow of a non-Newtonian so-called power-law fluid in a thin tube with a variable cross-section depending on a small parameter $$\varepsilon$$ , representing the ratio between the c...

Volume renormalization of higher-codimension singular Yamabe spaces

Abstract Given an embedded closed submanifold Σ n \Sigma^{n} in the closed Riemannian manifold M n + k M^{n+k} , where k < n + 2 k , we define extrinsic global conformal invariants of Σ by renormalizing the volume associated to the unique singular Yamabe metric with singular set...

Celestial amplitudes on electromagnetic backgrounds: T-duality from S-duality

Abstract What is the boundary holographic dual of S-duality for gauge theories in asymptotically flat space-times? Celestial amplitudes, by virtue of exhibiting holographic properties of the S-matrix, appear well-suited for studying this question. We scatter electrically and magn...

Automated optimization of force field parameters against ensemble-averaged measurements with Bayesian inference of conformational populations

Accurate force fields are essential for reliable molecular simulations. These models are refined against quantum mechanical calculations and experimental measurements, which are subject to random and systematic errors. Bayesian Inference of Conformational Populations (BICePs) is...

Urbanization and electoral success: lawyers and workers in interwar France

This study argues that urbanization altered the relationship between candidates’ occupation and their electoral success. To identify the causal effect of local variation in urbanization, we exploit exogenous changes in the boundaries of electoral constituencies in the 1928, 1932,...

ValuesML: A new multilingual dataset for values detection in news and political manifestos

Abstract Values are important building blocks of political ideologies and are frequently invoked in political debates. Yet, because values are abstract, understanding how they are expressed in real-world discourse, and how this varies across contexts, remains a challenge. In this...

Bayesian model discovery for reverse-engineering biochemical networks from data

Abstract The reverse engineering of gene regulatory networks based on gene expression data is a challenging inference task. A related problem in computational systems biology lies in identifying signalling networks that perform particular functions, such as adaptation. Indeed, fo...

Improved specificity of a probe-based real-time PCR for the detection of Dirofilaria immitis in canine blood

Abstract Background Dirofilaria immitis is a vector-borne filarioid nematode distributed worldwide and endemic across most of North America. In dogs, it is considered the most important parasite and a known cause of acquired cardiomyopathy. Clinically, canine heartworm disease ca...

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface

Abstract The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast cells in rat, exit the placenta,...

A simple demonstration of a privacy-preserving de-centralised genotype imputation workflow

Abstract Recently, a number of studies have looked at the problem of privacy and data-sharing restrictions in the context of missing genotype imputation servers. This relates to the most typical imputation pipelines which involve a whole-genome sequenced haplotype reference panel...

Data and context matter: towards generalizing AI-based software vulnerability detection

AI-based solutions demonstrate remarkable results in identifying vulnerabilities in software, but research has consistently found that this performance does not generalize to unseen codebases. In this paper, we specifically investigate the impact of model architecture, parameter...