Research works

A Darwin Core dataset of scorpions (Arachnida, Scorpiones) from the Royal Belgian Institute of Natural Sciences (RBINS) Collections

This data paper details the publication of a dataset derived from the scorpion (Order Scorpiones C.L. Koch, 1850) collections preserved at the Royal Belgian Institute of Natural Sciences (RBINS), Brussels. The dataset includes all 3,652 specimens mostly identified to genus or spe...

Reference-free microsatellite instability detection from tumor sequencing using intrasample variability modeling

ABSTRACT Microsatellite instability (MSI) is a key predictive biomarker across multiple tumor types, but current next-generation sequencing (NGS)-based callers oftendependon matched normals, large reference panels, or pretrained machine-learning models, which limits portability a...

Application-based coaching for recurrent urinary tract infections in adult women: design of a mixed-methods multicenter randomized controlled trial and process evaluation in the Netherlands

Abstract Background Recurrent urinary tract infection (rUTI) healthcare has proven to be a challenge due to different limitations. Digital coaching could provide a solution for these challenges. Earlier, we have developed a digital coach for women with rUTI and pilot-tested this...

Chronic stress disrupts the network among stress granules, P-bodies, and motor proteins

Stress granules (SGs) are dynamic RNA condensates that assemble rapidly in response to cellular stress following translational arrest, thereby promoting adaptation and influencing disease pathogenesis. Although SG assembly and disassembly during acute stress have been extensively...

Some generalized forward reflected backward methods for solving convex minimization problems

In this paper, we are concerned with the iterative approximation of solution to the unconstrained convex minimization problem in a real Hilbert space. Our first method is motivated by the recent advancement on the reflected backward method and the generalized reflected backward m...

A co-optimization qubit mapping algorithm via two-stage search and bidirectional look

Abstract Current quantum devices typically lack full qubit connectivity, making it difficult to directly execute logical circuits on quantum devices. This limitation necessitates quantum circuit mapping algorithms to insert SWAP gates, dynamically remapping logical qubits to phys...

Understanding-Aligned Intelligence Framework (UAIF): Which Parts of This Architecture Survive Cognitive Parity

Version 1.0.0 of this framework, published in January 2026, proposed a five-layer architecture for aligning an artificial system. At its base is a constitution derived from international human rights law. Above it sit a proof validator that checks certificates instead of searchin...

Near-extremal hydrodynamics and the holographic product formula

A bstract The holographic product formula is used to determine the general form taken by holographic spectral functions in the near-extremal hydrodynamic regime, with energy ω , momentum k and temperature T much smaller than a hard scale μ . The resulting expressions simplify in...

Operationalizing the Concept of Socio-environmental Tipping Points in River Basin Management

Abstract The concept of socio-environmental tipping points (SETPs) is gaining interest as a means to describe nonlinear transformations in socio-environmental systems that are driven by both biophysical and social dynamics. These SETPs stem from multiple interacting factors that...

Impact of South American biomass burning emissions on elevated South Atlantic upper tropospheric ozone

Abstract. During the SOUTHTRAC mission in autumn 2019 elevated mixing ratios of carbon monoxide (CO), carbon dioxide CO2, nitrogen oxide (NO) and total reactive nitrogen NOy were observed during a flight at the beginning of October. The potential plume extended over more than 100...

Psychosocial Factors Explaining Academic Dropout among Scholarship Students at a Public University in Peru

Introduction Student dropout in higher education is one of the most concerning issues on the agendas of countries, and it remains a challenge for the higher education system. This is reflected in cases where, despite the benefits and support provided by the state, students decide...

Coproducts internal to profinite spaces

We give a categorical explanation for many properties of profinite coproducts of profinite groups, which were previously proven on a case-by-case basis. All of these properties take the form "certain functors preserve profinite coproducts". We give various examples to show how ou...

Optimizing Gaussian process emulation and generalized additive model fitting for rapid, reproducible earth system model analysis

Abstract. Causes of model uncertainty in complex modeling systems can be identified using large perturbed-parameter ensembles (PPEs), combined with statistical emulators to increase sample size and enable variance-based sensitivity analyses and observational constraint. In global...

The $s$-chromatic Ramsey number for stars

In 1977, Chung, Chung and Liu generalized the definition of the Ramsey number. They introduced the $s$-chromatic Ramsey number as follows. Let $1\leq s< t$ be integers and let $A_{1}, A_{2}, \dots, A_{c}$ be subsets with size $s$ of $[t]$, where $c= {t\choose s}$. For given graph...

Investigating and comparing user experiences at EV charging and petroleum fueling stations

Light duty electrification requires DC charging stations to take over the current role of petroleum stations. However, charging and fueling systems differ substantially in technology, user behavior, and business models. This study analyzes thousands of reviews for petroleum stati...

δ2-Protocadherins organize parallel indirect basal ganglia circuits

Abstract The basal ganglia (BG) contain multiple parallel neural circuits, each of which may control different behaviors. However, how the distinct parallel BG circuits are molecularly organized is not known. Here we show that two δ2-protocadherins (PCDHs), PCDH17 and PCDH10, whi...

Longitudinal weighted and trimmed treatment effects with flip interventions

Weighting and trimming are popular methods for addressing positivity violations in causal inference. While well-studied with single-timepoint data, standard methods do not easily generalize to longitudinal data and remain vulnerable to time-varying positivity violations. We exten...

Cell Type‐Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment

Extracellular vesicles (EVs) mediate intercellular communication in the central nervous system (CNS) and are emerging as biomarkers of brain health and disease. However, the molecular composition of cell type-specific brain EVs, particularly astrocyte-derived EVs (ADEVs), remains...

Complementary strengths of the Neyman-Rubin and graphical causal frameworks

This article contributes to the discussion on the relationship between the Neyman-Rubin and the graphical frameworks for causal inference. We present specific examples of data-generating mechanisms — such as those involving undirected or deterministic relationships and cycles — w...

From optimistic to overwhelmed: exploring health beliefs and barriers to oral anticancer medication adherence among cancer survivors

Abstract Purpose This study explored cancer survivors’ health beliefs about oral anticancer medications (OAMs) and examined how these beliefs influence adherence-related decision-making, while identifying barriers and strategies to support cancer management. Methods Twelve patien...