Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
81853 work(s)
- BiologyOpen access
Allosteric regulation, whereby small molecules or mutations modulate protein function from sites distal to the orthosteric active site, is a pervasive mechanism of biological control and an important opportunity for drug discovery. Yet the prospective identification of allosteric...
- Society & EconomicsOpen access
Does cross-border regulatory cooperation reduce excessive risk-taking?
This study investigates how heightened regulatory scrutiny by the U.S. Securities and Exchange Commission (SEC), caused by the passage of the Multilateral Memorandum of Understanding (MMoU), affects excessive risk-taking by U.S. listed foreign firms. Using data from 37 countries...
- Engineering & TechnologyOpen access
Energy efficiency of miscanthus insulation for building walls in various world climates
The building sector is a major contributor to global energy consumption, highlighting the need for efficient and sustainable insulation materials. This study investigates the thermal and energy performance of miscanthus-based bio-sourced insulation applied to exterior building wa...
- Health & MedicineOpen access
Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map
Native T1 values in cardiac magnetic resonance (CMR) are influenced by acquisition sequence, physiological factors, and site-specific variability, complicating clinical interpretation. The absence of population-specific reference values further limits diagnostic accuracy. This st...
- Health & MedicineOpen access
BACKGROUND: Adult thalamic gliomas (ATGs) are rare and biologically heterogeneous tumors. Although the 2021 World Health Organization (WHO) classification designates all diffuse midline gliomas (DMGs), H3-altered, as grade 4, accumulating evidence suggests that adult thalamic DMG...
- AI & ComputingOpen access
Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies
The tumor microenvironment (TME) exhibits widespread immunophenotypic heterogeneity. Based on the spatial immune contexture, tumor immune profiles can be classified as immune-inflamed, excluded, or desert. Immune-excluded tumors, a distinct tumor immune phenotype, are characteriz...
- Society & EconomicsOpen access
Siân E. Halcrow, Sabrina C. Agarwal, Carlina de la Cova, Rebecca Gowland & Gwen Robbins Schug (ed.). 2026. Bioarchaeology, activism and social justice: equitable and sustainable global futures. Cham: Springer; 978-3-032-10353-6 hardback £44.99 ebook OpenAccess https://doi.org...
- Society & EconomicsOpen access
Subjective well-being of healthcare workers after Japan’s COVID-19 state of emergency
Healthcare workers (HCWs) are the cornerstone of pandemic response, yet their subjective well-being may be compromised by unavoidable occupational risks. While current research has documented the immediate psychological impact of COVID-19, fewer studies have tracked how self-repo...
- Health & MedicineOpen access
Dermatophytosis is a common fungal infection of keratinized tissues (skin, hair, nails) caused by dermatophyte fungi. Conventional treatments rely on synthetic antifungals that can be costly, slow-acting, and prone to resistance or side effects. This has spurred interest in natur...
- AI & ComputingOpen access
The Visualization of Jomon One-Dimensional Coordinate System
Every line segment has two endpoints. Ala denotes that the component of the tuple is the first component.
- Society & EconomicsOpen access
Critical incidents significantly impact teacher identity, either constructively or disruptively. However, without knowing which incidents are most impactful, interventions and long-term plans cannot be designed. This study aimed to identify and prioritize critical incidents from...
- Climate & EnvironmentOpen access
Contrasting seasonal roles of external forcing and internal variability in East Asian temperature
How to reliably separate external forcing (EXF) and internal variability (IV) components of regional temperature variation is of critical importance in East Asia. We implement here an EOF-based semi-empirical framework to avoid spurious teleconnections often present with conventi...
- Health & MedicineOpen access
Zingiber officinale Roscoe (ginger) hydrodistillation for essential oil production generates large quantities of residual cake, an underutilized by-product rich in non-volatile phenolics. This study characterized and quantified gingerols and shogaols in fresh Ecuadorian ginger rh...
- Health & MedicineOpen access
Purpose To evaluate salivary telomere length as a potential non-invasive exploratory biomarker for early molecular alterations associated with oral leukoplakia and oral squamous cell carcinoma. Methods Forty-five participants were initially recruited: 15 healthy controls, 15 leuk...
- Engineering & Technology
본 연구는 강화되는 PFAS 환경 규제에 선제적으로 대응하기 위해, 친환경 냉매 R744를 적용한 전기자동차용 히트펌프 시스템 내 판형열교환기의 열유동 성능을 3차원 CFD 해석을 통해 규명하였다. 쉐브론 패턴이 적용된 판형 열교환기를 포함한 3차원 모델을 구축하고, k-ω SST 난류 모델을 적용하여...
- Health & MedicineOpen access
Chikungunya fever among Japanese travelers: monthly and yearly trends in imported cases, 2011–2023
Objectives: Chikungunya poses an increasing threat to people living in endemic areas and to travelers from non-endemic regions. This study descriptively characterized imported chikungunya cases in Japan and explored the relationship between local incidence in destination areas an...
- Society & EconomicsOpen access
The rapid growth of environmental, social, and governance (ESG) investment products, perceived as representing responsible businesses, has made it imperative for investors to assess their effectiveness in insulating portfolios from geopolitical shocks. The current study investiga...
- BiologyOpen access
Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...
- Health & MedicineOpen access
Optimized technique for experimental multivisceral transplantation
Background There has been a shift toward combined liver-intestine and multivisceral transplantation (MVT), whereas isolated intestinal transplantation has taken a backseat, mainly because of its higher rejection rates. Despite this, experimental models tend to focus on intestinal...
- Engineering & TechnologyOpen access
Rotational canal scheduling in arid irrigation districts must satisfy coupled water-volume, timing, and hydraulic constraints while balancing modeled seepage loss and the dispersion of trunk-canal discharge levels. A constrained model with a weighted composite objective was solve...