Research works

Dissociation Between Functional Performance and Structural Joint Damage Following Sertraline Treatment in Collagen-Induced Arthritis

Rheumatoid arthritis is a chronic inflammatory joint disease often accompanied by depressive symptoms, in which functional impairment does not always reflect the extent of structural joint damage. Sertraline, a selective serotonin reuptake inhibitor, may influence behavioural and...

A 20-cm redundant vas deferens loop during late orchidopexy: aberrant ductal anatomy as an intraoperative pitfall in a 17-year-old male

Introduction and importance: Cryptorchidism is one of the most common congenital anomalies of the male genitourinary tract. Anatomical variations of the spermatic cord structures, though underreported, may increase the risk of iatrogenic injury during orchidopexy. Case presentati...

EuroMillions Breakthrough Mining — 1813 Sources, 13635 Leads Extracted — E8 Intelligence Research

Mined 1813 lottery+quantum breakthroughs. Extracted 13635 leads across 13 categories. 11628 high-value leads found. Categories: {"CORRIDOR": 1137, "FORMULA": 980, "GEOMETRIC": 726, "FORWARD_ATTEMPT": 1190, "QUANTUM": 1405, "TIMING": 208, "CELESTIAL": 1066, "GEMATRIA": 1137, "CONS...

Prompt Injection as an Architecture-Specific Attack Surface: Comparing LLM-Based and Traditional ML Spam Classifiers Under Adversarial Conditions

Large language models are increasingly deployed for text classification tasks that were previously handled by supervised machine learning. How the two approaches compare under adversarial conditions has received limited systematic attention, particularly in side-by-side evaluatio...

Halogen Substitution as a “Chirality Editor” for Amplifying Spin‐Selective Transport in Lead‐Free Metal‐Halide Hybrids

ABSTRACT Lead‐free metal‐halide hybrids hold promise as flexible semiconductors for X‐ray detection, but their application is constrained by inefficient carrier transport. Here, we introduce halogen substitution on chiral molecular cations as a “chirality editor” to modulate the...

Geometric Exclusion of Smooth Solutions to Navier-Stokes Equations at Stationary Right-Angles under No-Slip Boundary Conditions in Lean 4

This paper presents a proof by contradiction demonstrating that smooth solutions to the three dimensional incompressible Navier-Stokes equations do not exist for all time. Our argument is a direct consequence of a specific no-slip boundary condition: a stationary right-angle corn...

The Limits of Comorbidity Indices in TAVI: How Aggregation Dilutes the Prognostic Power of Individual Biomarkers

Objective. Heart-team decisions in transcatheter aortic valve implantation (TAVI) lean on EuroSCORE II, yet the comorbidity burden that often drives the final choice is rarely scored. We tested a specific two-part hypothesis: whether formally quantifying comorbidity burden (via t...

Emergence of biosignatures on Earth and implications for life detection

Earth’s organic chemical evolution (OCE) from abiotic to prebiotic to biotic provides critical insights that may have implications for how we interpret observations made by life-detection planetary missions. To search for life on other worlds, astrobiologists seek biosignatures:...

Development of Machine Learning Models for Predicting the Fertilizer Suction Characteristics of an Asymmetric Venturi Injector

The fertilizer suction performance of Venturi injectors is jointly governed by fertilizer-solution properties and hydraulic boundary conditions, resulting in multivariable and potentially nonlinear responses that may be difficult to characterize using simplified empirical relatio...

Network pharmacology–based prediction of the multi-target mechanism of Simhanada Guggulu in rheumatoid arthritis: an in silico study

Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder characterised by persistent synovitis, progressive cartilage and subchondral bone destruction, functional disability and systemic complications. Current disease-modifying therapy has substantially...

TPS10 contributes to linalool emission in rice in response to brown planthopper infestation

Abstract BACKGROUND Terpenoids, a prominent class of herbivore‐induced plant volatiles, play a crucial role in plant responses to insect attacks. However, the precise ecological functions of individual terpene synthases in rice defense mechanisms remain unclear. RESULTS The level...

Aligning protein-generative models to experimental fitness with ProteinDPO

Abstract Biological generative models can predict biological functions without task-specific training data but often under-perform specialized models. This is due to a fundamental ‘alignment gap’, where the rules learned during unsupervised training are not related to the functio...

Role of Glycerol-3-Phosphate Dehydrogenase in the Development, Pathogenicity, and Glycerol Biosynthesis of Aspergillus flavus

Aspergillus flavus, a ubiquitous phytopathogen, produces mycotoxins, especially aflatoxin B1 (AFB1), and infects crops worldwide. Glycerol-3-phosphate dehydrogenase (G3PDH) is a key enzyme in the glycerol synthesis and metabolic pathway catalyzing the reversible conversion reacti...

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial

Abstract Background SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymeras...

Hemodynamic integration in extracorporeal membrane oxygenation anticoagulation

Despite progressive advances in circuit design, material biocompatibility, and anticoagulation monitoring, bleeding and thrombosis remain common during extracorporeal membrane oxygenation and are closely associated with adverse outcomes. Current practice still relies mainly on he...

Numerical Study of Flow Characteristics of Pressure Relief Valve based on a Structure for a Liquid Hydrogen Storage System

지구온난화로 인해 이상기후 현상이 심화되면서 화석연료를 대체할 에너지원으로 수소에너지가 주목받고 있다. 하지만, 기체수소는 높은 위험성으로 인해 배터리에 비해 대중화가 더딘 실정이다. 본 연구에서는 기체수소의 고압 위험성을 개선한 액체수소 저장시스템에 적용되는 압력해소밸브에 대하여...

Machine learning-based winner prediction in elite kickboxing: a technical-tactical performance analysis

To develop and validate machine learning models for predicting match outcomes in elite kickboxing based on technical-tactical performance indicators and to identify the key variables distinguishing winners from defeated athletes. Video analysis was conducted on 142 elite kickboxi...

Failure mechanism of anchorage bearing structure in deep roadway under superposition of dynamic and static loads

To investigate the mechanical response of anchorage bearing structures in deep roadways under dynamic loading, a physical simulation test was conducted to analyze the evolution of the strain field under combined static and dynamic loads. A mechanical load-transfer model of the an...

Improving Functional Oral Intake in Head and Neck Cancer Survivors with Chronic Radiation-Associated Dysphagia – The Multicenter Randomized Controlled HIT-CRAD Trial

This randomized controlled trial evaluated the efficacy of home-based treatment programs for chronic radiation associated dysphagia (CRAD) in head and neck cancer (HNC) patients, comparing high-volume strength training to combined strength-skill training with either real or sham...

Hybridizing MXenes with MOFs: a pathway to smart sensing platforms and efficient water remediation

The need for the efficient platforms creating innovative applications in the field of sensing, wastewater treatment, and industrial safety has resulted in the development of novel and advanced hybrid materials with unique morphological structures and superior performance. Hybrid...