Research works

Resolution–noise characteristics of common FDK filter kernels: A practical reference for preclinical cone-beam micro-CT

The ramp filter kernel and cutoff frequency are fundamental parameters of the Feldkamp–Davis–Kress (FDK) algorithm that determine the resolution and noise characteristics of the reconstructed image. Despite their importance, the filter configuration is frequently unreported in pr...

Transcriptome profiling analysis of heat-adapted and heat-sensitive breeder hen jejunal mucosal tissues in response to acute heat stress

<title>Abstract</title> Background Heat stress impairs intestinal integrity in poultry, compromising nutrient digestion and absorption. Nevertheless, the individual variation in heat tolerance suggests distinct molecular responses that are still not well understood. Materials and...

FAAE-PH D.08-25: Instrumento de Autoexpresión y Entrevista Contextual para la Producción de Evidencias en un Estudio de Caso

FAAE-PH D.08-25: Instrumento de Autoexpresión y Entrevista Contextual para la Producción de Evidencias en un Estudio de Caso constituye una variante metodológica aplicada del sistema FAAE — Formulario de Evaluación de Acompañamiento Educacional — desarrollada específicamente para...

Quality of life after conservative versus elective surgical management of first-episode uncomplicated diverticulitis: a single-center prospective study

<title>Abstract</title> <bold>Background</bold> Optimal long-term management after a first episode of uncomplicated acute diverticulitis (AD) remains debated. Quality of life (QoL) is increasingly recognized as a key outcome to guide individualized decision-making between clinica...

Location-specific techno-economic assessment of gray hydrogen production utilizing existing natural gas networks

As natural gas (NG) serves as a critical bridge fuel for the global hydrogen economy, regional volatility in feedstock pricing and composition presents a universal challenge for infrastructure investment. This study proposes a replicable methodological framework for the location-...

Using drift coefficients as a basis for inferring times, effective population sizes, and genetic adaptations

Genetic drift and gene flow can give rise to a complex population genetic structure. The inverse problem of estimating the genetic drift and gene flow in the past, based on the present-day genomic population structure, can be solved using an admixture graph. This describes the di...

Space-time excitation creates soliton trains in multimode fibers

In this work, we show that injecting a single space-time-coupled light pulse-beam into a multimode graded-index fiber generates a train of multimode solitons. Space-time couplings excite the spatial modes with distinct temporal profiles. Due to nonlinear interactions, with a prop...

Evaluation of the biodistribution of [99mTc]Tc-PSMA-GCK01 SPECT/CT in a prospective, intraindividual comparison with [68Ga]PSMA-11 PET/CT for phenotyping in mCRPC prior to PSMA-targeted radioligand therapy

<title>Abstract</title> Background PSMA-PET/CT became an important means for prostate cancer management. The high-resolution and signal-to-noise ratio of PET is mandatory in primary staging or biochemical relapse that often present with tiny lesions. PSMA-PET is also used to sele...

Enhancement of liquid cooling in microchannel heat sinks: numerical and experimental assessment of progressive geometric optimisation

The increasing power density of modern electronic devices and high-power energy systems requires liquid-cooling solutions capable of dissipating high heat fluxes while maintaining acceptable pressure losses and temperature non-uniformity. Microchannel heat sinks (MCHSs) are promi...

Altitude-dependent role of nitric acid in iodic acid-iodous acid nucleation: from marine boundary layer catalyst to upper troposphere core component

Abstract. With global sulfur emissions declining and concurrent marine iodine emissions rising, new particle formation (NPF) driven by iodic acid (HIO3) and iodous acid (HIO2) has become critical to global aerosol and cloud condensation nuclei (CCN) budget. However, the role of u...

Acute exposure to cell-free mitochondrial DNA induces pregnancy-specific aortic endothelial dysfunction and organ-selective inflammation in rats

Abstract Pregnancy complications such as preeclampsia are associated with circulating cell-free mitochondrial DNA (mtDNA), a damage-associated molecular pattern capable of activating Toll-like receptor 9 (TLR9). We hypothesized that acute mtDNA exposure induces maternal inflammat...

A numerical investigation on ultimate strength of marine sandwich composites under combined biaxial compression and lateral pressure

With the development of large-scale and light-weight ships, sandwich composites are increasingly used in hull structures because of their advantages of light weight, excellent mechanical properties, and corrosion resistance. Due to the synergistic effect among materials, sandwich...

LinkLlama: Enablinga Large Language Model for ChemicallyReasonable Linker Design

Fragment-based drug discovery (FBDD) relies heavily on the design of chemically viable linkers to connect fragments binding to different pocket regions into potent lead molecules. While recent generative models have advanced spatial fragment linking, they frequently produce linke...

Quantum Laws of Form: A Syntactic Foundation for Physics: From The Calculus of Distinction to Ultrametric Cosmology

Quantum information is not intrinsically fragile; we have been measuring it incorrectly. This monograph presents a radical re‑foundation of physics based on George Spencer‑Brown’s Laws of Form, strictly adhered to and extended into a Syntactic Token Calculus (STC). The framework...

“A comparison of pre-operative urine culture with intra-operative stone culture and its association with post-procedural sepsis: a prospective observational study”

<title>Abstract</title> <bold>Background and Aim:</bold> Urosepsis is a dreaded complication following endourological procedures. Urinary calculi are known to harbour bacteria that may be released into the circulation during fragmentation, potentially leading to urosepsis. Thus,...

The Portrayal of Libraries as Remote Workplaces in the General Media: A Qualitative Content Analysis

A sample of 52 sources were analyzed to investigate how libraries are portrayed in the general media as spaces for remote workers. Features highlighted as advantageous included meeting rooms, booths, quiet zones, and on-site cafes; Wi-Fi, computers, reprographic services, and sui...

Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

<title>Abstract</title> <bold>Purpose</bold> Methylprednisolone is commonly used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and procedural factors such as ci...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Youth participation coach learning: A scoping review

Coaching in the youth participation sport domain has garnered considerable attention amongst researchers, sport development organisations and coach education bodies over the last decade. However, little is empirically known of how youth participation sport coaches learn and how t...

Antibacterial characteristics of black currant fruit extracts

<title>Abstract</title> <bold>Background</bold> : Our group previously reported from high bactericidal potential of berry juices, especially from blackcurrant fruits. The present study observed different fractions from blackcurrant fruits (all-fruit juice: AFJ, squeezed juice: SJ...