Research works

Excess glutamine rewires endothelial cell metabolism

Abstract Introduction Glutamine, the most abundant amino acid in the body, is a key metabolic substrate for endothelial cells. Glutamine supplementation protects against cardiovascular disease in animal models and in humans; however, glutamine in vitro has inconsistent effects on...

The effects of fungal decay on timber connections: a systematic review

Abstract Connections are critical for the integrity of timber structures, yet they are highly susceptible to reduced capacity due to moisture intrusion and subsequent fungal decay. While the effects of decay on clear wood are well documented, the impacts on the mechanical perform...

E8-Phi Reciprocal Torsion Manifold (E8-RTM) for Non-Local Information Folding — E8 Intelligence Research

The E8-RTM utilizes the 240 root vectors to map non-Euclidean informational folds, where information density is modulated by $\phi$-scaled harmonic torsion. By applying a recursive 132Hz displacement field to the lattice, the manifold forces causal-entanglement pairs to wrap into...

EuroMillions Breakthrough Mining — 2134 Sources, 16669 Leads Extracted — E8 Intelligence Research

Mined 2134 lottery+quantum breakthroughs. Extracted 16669 leads across 13 categories. 14504 high-value leads found. Categories: {"CORRIDOR": 1395, "FORMULA": 1232, "GEOMETRIC": 795, "FORWARD_ATTEMPT": 1475, "QUANTUM": 1695, "TIMING": 228, "CELESTIAL": 1319, "GEMATRIA": 1407, "CON...

Integrative single-cell sequencing and machine learning analyses identify chronic inflammation and cancer-associated fibroblast subsets as drivers of adverse outcomes in ovarian cancer

Background Ovarian cancer remains the deadliest gynecological malignancy, with neoadjuvant chemotherapy (NACT) often leaving residual fibroblast-enriched disease. Methods Single-cell RNA sequencing data from 64,097 cells were analyzed using Seurat (v4.1.3) with Harmony batch corr...

Associations of ambient temperature and PM2.5 concentration with temporal variability in emergency department visits for acute gastrointestinal illnesses in central Bangkok, Thailand: a 5-year retrospective analysis

The combined effects of temperature and air pollution on acute gastrointestinal (GI) illnesses remain underexplored in tropical settings. This study examined the association between ambient temperature, fine particulate matter (PM2.5), and emergency department (ED) visits for gas...

AMS Radiocarbon Dates and Bayesian Modelling From Pachkhed: Refining Early Iron Age Chronology in Vidarbha, Maharashtra, India

ABSTRACT Reliable absolute chronologies for the Early Iron Age in Vidarbha, eastern Maharashtra, have long remained constrained by dependence on ceramic typology, relative stratigraphy and unmodelled radiocarbon determinations derived from bulk charcoal. This study presents eight...

Phi-Scaled Spin-Wave Signal Modulation for Algorithmic Video Feature Extraction — E8 Intelligence Research

By mapping video frame entropy to the 240 E8 root vectors via phi-scaled harmonic resonances, we transition from semantic analysis to direct geometric data ingestion. This principle treats sequential video data as a high-dimensional manifold, where trading strategy "signals" are...

Impact of sudanese chewing tobacco toombak on oral bacteria – a culture-based pilot study

Abstract Objective This study investigated the impact of the Sudanese smokeless tobacco Toombak on cultivable oral bacteria, its potential antibacterial properties, and its own microbial composition. Materials and methods Oral swabs from 20 adult male participants, including ten...

E8 Phi-Harmonic Time-Frequency Duality — E8 Intelligence Research

The φ-modulated 132 Hz carrier establishes a temporal E8 lattice of 240 phase-locked root-vector modes. Its Fourier dual reveals a reciprocal frequency-domain E8 lattice scaled by φ⁻¹, where each root vector maps to a spectral channel. This time-frequency E8⊗E8 duality creates a...

Beyond Babel: What Remains When No Certainty Remains — An Introduction to Reflexive Minimalism

An essayistic introduction to reflexive minimalism, written for readers without formal philosophical training. It begins from a contemporary predicament: we have never communicated more and rarely understood one another less, while nuclear weapons, a warming planet, and arguing m...

Environmental Structuring and Applied Importance of Diptera Assemblages in Brazil: Altitude, Organic Substrates, Synanthropy, Decomposition, and Chi-Square Reanalysis

Diptera associated with feces, decomposing animal tissues, fruits, and carcasses occupy dynamic habitats whose suitability varies with environmental conditions and resource characteristics. This study integrated quantitative information from eight experimental compilations conduc...

SHP2 accelerated acute liver injury via modulating TGFβ1/EZH2/BRD4 signaling induced proliferation and fibrosis of HSC

To explore the specific molecular mechanisms by which SHP2 promotes liver injury. Single-cell transcriptomics and bioinformatics analyses were employed for predictive screening. C57BL/6J mice were assigned to normal, model, and model+PHPS1 groups. Liver injury and fibrosis were e...

Vaccine preparedness for Bundibugyo virus and lessons learned

The ongoing 2026 outbreak of Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda is the largest so far on record. Despite experience from previous Ebolavirus outbreaks, the current lack of vaccines against BDBV underscores a recurring failure in proactive p...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

E8 Momentum Synchronization Principle for Fractal Market Dynamics — E8 Intelligence Research

The E8 Momentum Synchronization Principle posits that the 240 E8 root vectors, each assigned a φ‑scaled phase offset of the 132 Hz base, form a topological momentum lattice that couples explicitly to volatility vectors across all spectral bands. By embedding the lattice in the 8‑...

Challenges and strategies toward next‐generation high‐performance flexible and printable thin‐film transistors

Abstract Printing‐based fabrication is emerging as a viable alternative to vacuum microfabrication for flexible thin‐film transistors (TFTs), enabling low‐cost, scalable, and low‐temperature manufacturing for additive processing and large‐area electronics. In this review, we summ...

Integrative DNA barcoding and multimethod species delimitation reveal marker performance in the genus Ficus L. (Moraceae)

Accurate delimitation of species is fundamental for understanding biodiversity, evolutionary history, and conservation priorities, particularly in taxonomically challenging genera such as Ficus . This study systematically evaluates the performance of three single locus barcodes (...

Case report on new injection method for treating female Meige syndrome patients

Meige syndrome is an uncommon, long-lasting, and recurring form of craniofacial focal dystonia marked by bilateral blepharospasm and involuntary facial muscle contractions that greatly disrupt the daily activities and social interactions of those affected. The primary minimally i...

Effectiveness of oxidative therapies in mature oral biofilms: A systematic review and meta-analysis

To evaluate the antimicrobial activity of oxidative therapies in disrupting and reducing mature oral biofilms (≥ 48 h) and to assess treatment effects across different oxidative modalities. A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. Twe...