Research works

From graph Laplacian to ring polymer dynamics: part I

Abstract A graph-theoretic formulation of overdamped Langevin dynamics and constitutive equations for ring polymers is developed. The polymer molecule is represented as a bead–spring network whose connectivity is described by a graph Laplacian. Starting from overdamped stochastic...

Consumer Purchase Patterns for Millet-Based Food Products: An Empirical Analysis of Awareness, Attitude and Buying Behaviour

Millets are nutrient-rich, climate-resilient cereals with significant potential to support nutritional security, sustainable agriculture, and diversified food systems in India. This study examines consumer buying behaviour, awareness, preferences, satisfaction, and market trends...

E8 Fractal-Scaling Resonance for Multiscale Neural Processing — E8 Intelligence Research

By exploiting the 240 E8 root vectors as a fractal lattice, phi-scaled 132Hz oscillations enable neural encoding across spatial and temporal scales. Fractal geometry generated through vector superposition allows simultaneous handling of fine sensory details and holistic cognition...

P1.209. Long-Term Survival Outcomes After Esophagectomy for Cancer in Australia

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Five-year overall survival following esophagectomy for esophageal cancer is infrequently reported at a national level. This study investigated the influence of hospital annua...

Assessing AI-Mediated Interviewing Quality: A Theory-Grounded Comparison of Models for Evaluation Data Collection

As large language models are increasingly used in evaluative settings for their conversational potential in interviews, systematic frameworks for assessing their methodological quality are still lacking. Drawing on evaluation, qualitative interviewing, and validity theories, this...

Complex-Plane-Inspired Magnitude Rectifier: An Exploratory Transformer Activation Study

This exploratory preprint studies a complex-plane-inspired magnitude rectifier (CIMR), a real-valued activation that retains negative-input magnitude through a beta-scaled orthogonal construction. The scalar form reduces to a smoothed asymmetric absolute-value rectifier; it is no...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Ultramassive Black Star Cosmology: Quantum Phase Transition and Singularity-Free Cosmic Bounce

This preprint proposes an alternative model to the initial Big Bang singularity by postulating that the observable universe originated from the quantum bounce of an ultramassive object ("Black Star") containing the total mass-energy of the cosmos ($\approx 10^{53} \text{ kg}$). U...

Contrasting mechanisms of present-day vertical deformation along the northeastern Tibetan Plateau: Insights from 3-D viscoelastic modeling

Summary The northeastern margin of the Tibetan Plateau exhibits pronounced spatial variations in present-day vertical crustal deformation, yet the mechanisms controlling these differences remain debated. In particular, contrasting uplift patterns are observed between the Liupansh...

Zanidatamab in patients with early stage HER2-positive breast cancer: the NeoZanHER phase 2 single-arm open-label trial

Strategies are needed to avoid chemotherapy in early stage HER2-positive (HER2 + ) breast cancer (BC). We conducted a neoadjuvant therapy trial with zanidatamab, a dual HER2-directed bispecific antibody, in patients with 1-3 cm, node-negative HER2 + BC. Primary endpoint was patho...

P1.105. Epithelial–Mesenchymal Plasticity Underlies Adaptive Resistance to FLOT Chemotherapy in Esophageal Adenocarcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Resistance to perioperative FLOT chemotherapy remains a major determinant of poor outcome in esophageal adenocarcinoma. Epithelial–mesenchymal plasticity (EMP) enables dynamic cell state transitions that may...

Recurrent Stage 3 Sacral Pressure Injury in a Patient With Fistulizing Crohn's Disease: Clinical and Social Considerations

Pressure injuries are challenging chronic wounds because healing depends on systemic and patient-specific factors in addition to local wound care. Patients with Crohn's disease may be particularly vulnerable to impaired healing because chronic inflammation, nutritional compromise...

Ael-504M: A Sub-Billion Parameter Hybrid Mamba-2 and Delta-Attention Any-to-Any Multimodal Architecture

Ael-504M is an original sub-billion parameter multimodal foundation model engineered for high-throughput on-device reasoning and cross-sensory synthesis. Key Architectural Innovations: Dual-Brain Sequence Modeling: Interleaves Mamba-2 State Space Duality (SSD) for continuous O(L)...

HIOF·Dimensions as Illusions — Paper II: Subjective Determinism — You Are Your Dimension

Holographic Information Ontological Framework - Dimensions as Illusions A five-paper series on the deconstruction of spatial dimension This is a short, non-technical companion to the five-paper HIOF-DaI series. It is written for readers with a background in theoretical physics, p...

Reliability of Bonini's semiological classification in frontal lobe seizures: A video‐ EEG based study

Abstract Objective Frontal lobe seizures have heterogeneous semiology, making electroclinical localization challenging. Bonini et al. proposed a semiological classification based on rostrocaudal frontal lobe organization. We evaluated its interobserver and intraobserver reliabili...

Antimatter as Reverse-Cascade: A Geometric Resolution of the Dirac Time-Reversal Paradox in Fractal Mechanics

The Dirac equation predicts antimatter as negative-energy solutions equivalent to particles propagating backward in time — an interpretation that has remained physically unsatisfying for 95 years. We propose a geometric resolution within Fractal Mechanics (FM): antimatter is not...

On Chronotope (On the Spatiotemporal Complex, or Chronotope / Programmatic Theses & Historical Essay, 1925)

The theses of A. A. Ukhtomsky’s 1925 lecture On the Spatiotemporal Complex, or Chronotope represent an early attempt to apply the ideas of space-time associated with Minkowski and Einstein to the physiology of perception and behavior. Ukhtomsky considers the organism as a system...

E8‑Phi Quantum Entrainment of Cortical Grids — E8 Intelligence Research

The E8‑Phi Quantum Entrainment principle shows that the 240 E8 root vectors, phi‑scaled at 132 Hz, form a higher‑dimensional spinor lattice that functions as a topological waveguide for cortical neurons. This lattice generates a coherent interference field that encodes hierarchic...

Familial Genomic Architecture in Autism: A Trio-Based Multiscale Extension of the Genomic Complexity Index (GCI)

This record presents an exploratory single-family genomic study and methodological proof of concept focused on autism spectrum disorder (ASD). A father–mother–child trio was evaluated through sequential layers of Mendelian quality control, pedigree-aware phasing, reference-panel...

Full Metal Crown for the Treatment of a Damaged Restoration in an Alaskan Brown Bear ( Ursus arctos gyas )

The purpose of this article is to provide a step-by-step description of the creation and cementation of a full metal crown to restore a damaged maxillary canine tooth in an Alaskan brown bear. It outlines the complete process, including obtaining a tooth-specific impression, fabr...