Research works

Navigating Multifaceted Approaches in the Management of Parkinson's Disease

Parkinson’s disease is a progressive neurological disorder that results from damage to the dopamine-producing neurons in the substantia nigra of the midbrain, subsequently affecting the nigrostriatal dopaminergic pathway of the Basal ganglia. It is essentially vital to take an el...

Intentional Semantic Geometry: Statements as Grammar-Mediated References into Determinable Spectra

Non-trivial scientific meaning is not, in general, a proposition in a fixed logic-space. A statement is a pointer into a semantic geometry - a spectrum - and its interpretation is grammar-mediated: a grammar decides how the statement names regions or positions in the spectrum. Bo...

Estimating lower bound functions in surrogate optimization

Abstract Lower bounds play a vital role in optimization by guiding search, improving solution quality, and quantifying optimality gaps. In expensive black-box settings, however, the quality of Lipschitz-based estimated lower bounds can deteriorate when function behavior varies ac...

Damnacanthal from Morinda citrifolia L.: Experimental Characterization, Biological Evaluation, In Silico ADMET Assessment, and Future Perspectives in AI-Assisted Anticancer Drug Discovery

Natural products are a prominent source of structurally diverse bioactive molecules for anticancer drug discovery. Among these, anthraquinones are a class of compounds with antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Damnacanthal is a naturally occur...

Cognitive Offloading in the Age of AI: Are Students Thinking Less or Learning Differently?

The rapid integration of Artificial Intelligence (AI) into education has transformed the way students learn, solve problems, and access information. AI-powered tools such as ChatGPT, Gemini, Microsoft Copilot, and intelligent tutoring systems have emerged as valuable learning com...

Trust Readiness Before Judgment (TRBJ): Frozen Seed and Open Research Invitation — Version 1.0

Trust Readiness Before Judgment (TRBJ) is an open research proposition concerning the conditions that should be ready before a consequential judgment is relied upon. This Version 1.0 freezes a lightweight 4+1 reference structure: Boundary, Definition/Calibration, Rule/Factor, Evi...

Iberia and Uganda: Feminization, Urbanism, Distraction and Flat Out Lies

Comparative institutional analysis of Iberia (Spain and Portugal) and Uganda. The study shows how high taxation, regulatory density, fiat expansion, and official narratives have produced fertility collapse, rural demographic hollowing, labor-market distortions, monoculture prefer...

Objects in the Ontology of EFOS: Types, Properties, and Place in the Hierarchy of Forms of Matter

This article provides a systematic description of objects within the ontology of EFO (Entity Forming Objects) in the context of EFOS (Entity That Forming Objects and Subjects). The work is the logical completion of the ontological triad: EFO → EFOS → Subjects → Objects. The objec...

Operational Routing Intelligence (ORI): A Reference Architecture for Evidence-Based Adaptive Routing in Wholesale VoIP Networks

Adaptive wholesale VoIP routing is often implemented as a direct mapping from quality metrics to route changes, leaving the operational justification implicit. This paper defines Operational Routing Intelligence (ORI), a reference architecture that separates observation, reliabil...

The forgotten organ: An ontological theory of fat deposition.

This paper describes adipose tissue not as an energy storage medium, but as a distributed processing organ that protects the body from toxic overload. When too many carbohydrates and fats enter the bloodstream simultaneously, a concentration is created that the body cannot immedi...

Low-Rank Segre Geometry, Automorphism Groups, and Complement Cohomology of a Binary Two-Step Algebra

This paper determines the intrinsic geometry, symmetry structure, and complement cohomology of an explicit forty-three-dimensional two-step nilpotent associative algebra over the binary field and of its associated algebra group. The contraction ranks of the induced quadratic map...

Objects in the Ontology of EFOS: Types, Properties, and Place in the Hierarchy of Forms of Matter

This article provides a systematic description of objects within the ontology of EFO (Entity Forming Objects) in the context of EFOS (Entity That Forming Objects and Subjects). The work is the logical completion of the ontological triad: EFO → EFOS → Subjects → Objects. The objec...

Artificial Intelligence for Early Heart Disease Prediction: A Review of Machine Learning Techniques

Cardiovascular disease (CVD) is still the number one cause of death worldwide and many patients are exposed to severe cardiac events only after the disease has progressed to an advanced stage. Recent advances in artificial intelligence (AI) and machine learning (ML) have shown gr...

The Kernel Deficit Dominates Twice the Hull Deficit

For a simple polygon F in the plane, the kernel K(F) is the set of points that see all of F, and the convex hull C(F) measures how far F is from being convex. We prove that the two associated losses are linked by a sharp factor of two: area(F)(area(F) − area(K)) ≥ 2·area(K)(area(...

Theatre for Development: A Viable Means for Promoting Positive Attitudes towards Sanitation in Warabeba in the Winneba Municipality of the Central Region of Ghana

An undergraduate research work submitted to the University of Education, Winneba, for the award of Bachelor of Arts in Theatre Arts, in 2018. A qualitative research work which dealt with the promotion of positive attitudes towards proper sanitation in the Warabeba community, usin...

From Causality to Containment: Empirical Testing of Structural Determination and Its Implications for the Structural Depth Framework

From Causality to Containment: Empirical Testing of Structural Determination and Its Implications for the Structural Depth Framework This research article presents an empirical investigation of the containment-based determination architecture developed within the Structural Depth...

One-Way Permutations and the Conditional Unprovability of Exact Semantic Carrier Separation in PV

The Exact Semantic Carrier condition EC1b requires a distinguishing admitted query whenever two carrier codes differ. We study this requirement in a fixed conservative definitional extension of Cook's universal theory \(\mathbf{PV}\). A width \(n\) is represented by a supplied ma...

On Central Immunological Tolerance Defects and Oncogenesis: A Closed-Loop Deduction Based on the X+n/X−n Thymic Selection and Immune Surveillance Model

Traditional oncology often posits environmental exposure and gene mutations as the primary causal factors in cancer development. However, epidemiological paradoxes—such as the high cancer incidence in countries with pristine natural environments, significant age-standardized inci...

A Cluster-Based Information System for Supporting Post-Harvest Loss Reduction in Sri Lanka's Traditional Fruit and Vegetable Supply Chain

Post-harvest losses remain a major problem in Sri Lanka’s traditional fruit and vegetable supply chain. This study was conducted to understand how the supply chain operates in practice and to identify the challenges faced by actors at different stages. A qualitative exploratory a...

Fixed-Function Exact Semantic Carrier Conditions over VPV: Internal Invariants and External Representation Theorems

Fix Cook--Nguyen's two-sorted language \(L_{FP}\), its universal theory \(VPV\), and named \(L_{FP}\)-functions for admittedness, response, preparation, carrier coding, decoding, and dynamics. With the instance string as a free parameter, we give bounded formulas for response sou...