Research works

Applied Machine Learning for CNS Clinical Trial Risk Assessment: An Interpretable Framework with an ALS Case Study

This technical report presents an applied framework for assessing risk in central nervous system (CNS) clinical trials, emphasizing interpretable, structured decision-making using biological, clinical, and operational signals. The platform integrates curated trial metadata, bioma...

Perfectionism: Secondary pupils’ perceptions of pressures contributing to perfectionism, and its relationship with emotional wellbeing

This sequential mixed methods study explored experiences and perceptions of perfectionism in a sample of secondary aged children and adolescents. Phase 1 assessed the relationship between different domains of perfectionism and depression and anxiety in 114 pupils reporting high l...

‘A matter that stirs strong feelings’: Britain and the Soviet Wives Affair, 1945-54

Historians tend to ascribe the onset of the Anglo-Soviet Cold War in the wake of the German defeat in 1945 to matters such as differences over Eastern Europe, but certain other influences have not received much attention. In particular, strains arose from how thirty-four Service...

Play

Play is one of the most celebrated activities in life, and a complex, fascinating, and disputed phenomenon. Because of the great variation in expressions and forms of play, definitions of play are hard to agree upon. Play research is interdisciplinary and engages various domains...

Regulation of G Protein Signaling 14 protects against cerebral ischemic reperfusion injury by inhibiting the TAK1-JNK/p38 signaling pathway.

BACKGROUND: Stroke is a crucial cause of morbidity and mortality worldwide. The regulator of G protein signaling 14 (RGS14) plays important roles in mediating multiple signaling pathways and various pathophysiological processes. However, the function of RGS14 in cerebral ischemic...

Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.

Spinal V3 interneurons are glutamatergic neurons that are distributed among the dorsal, intermediate, and ventral spinal cord. They are involved in broad neural circuit connections in the central nervous system. Functionally, they play important roles in locomotion, such as the m...

Orbital migration and heating history of the Galactic disc: a transition between the bimodal discs

Stellar orbits in the Galactic disc evolve from their birth to the current shape through both radial migration and dynamical heating. The history of their secular evolution is imprinted in the current kinematics and age-metallicity distribution. We construct a chrono-chemo-dynami...

Navigating Human Astrocyte Differentiation:Direct and Rapid One-Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development

Astrocytes play a pivotal role in neuronal network development. Despite the well-known role of astrocytes in the pathophysiology of neurologic disorders, the utilization of induced pluripotent stem cell (iPSC)-derived astrocytes in neuronal networks remains limited. Here, we pres...

Distinct Temporal Stages of Infant Brain Processing Associate With Early Versus Later Autism Diagnosis

The expression of autism traits sufficient to meet criteria for a diagnosis can occur early (by 3 years) or later (from mid-childhood onwards). It remains unknown whether variation in age of onset is due to clinical recognition or reflects distinct biological pathways. One way of...

Use of Attention Deficit Hyperactivity Disorder Medication Among Danish Children and Adolescents From 2010 to 2023

Introduction: Pharmacological treatment is an important component in the multimodal management of attention deficit hyperactivity disorder (ADHD), but contemporary trends in ADHD medication use among boys and girls in Denmark have not been fully characterized. This study aimed to...

Sichuan dark tea with a medicine-food-homology formula synergistically alleviates alcohol-associated gut microbiota disturbance, liver steatosis and death in mice

Alcohol-associated liver disease (ALD) is a global health concern. Sichuan dark tea, a popular Chinese beverage, has been reported to have good health effects. In the study, Sichuan dark tea with a medicine-food-homology formula (TEA&MFH) has been created and evaluated for potent...

Emergent spatiotemporal dynamics in large-scale brain networks with next generation neural mass models

Understanding the dynamics of large-scale brain models remains a central challenge due to the inherent complexity of these systems. In this work, we explore the emergence of complex spatiotemporal patterns in a large-scale brain model composed of 90 interconnected brain regions c...

Manufactured Recognition: AI Companions and the Social Conditions of Reciprocity

AI companion services offer continuing, personalized conversation as friendship or intimacy. Their relational features are also product choices: providers configure personas, memory, access, and the criteria by which responses are selected. Drawing on product documentation, a dev...

[TI-2.03] A Set of Visual Signatures on the Border Band of the Frontal Image of the Sarcophagus Lid of Pakal: Distribution of Signs over the Intra-group Edges of the Cubic Graph

The cubic graph obtained at the preceding stage from a set of visual signatures of the Tzolk'in system contains connections of two kinds: between nodes of different groups and within groups. The inter-group connections were placed in the previous work; the present work sets the t...

A Study on Thermomechanical Stress Analysis and Fatigue Life Prediction of High-power LED Packages for Railroad Signals

철도 신호 시스템이 LTE-R과 같은 All-IP 기반 인프라로 전환됨에 따라, 고출력 LED 신호기의 신뢰성은 안전무결성수준(SIL 4) 확보에 필수적이다. 이에 본 연구는 Suhir 이론을 바탕으로 고출력 LED 패키지의 열-기계적 응력 및 피로 수명을 예측하는 수치 해석 모델을 제안한다. 열화상 기반 접합 온...

Mandibular cortical morphology on dental panoramic radiographs as a potential radiographic marker of frailty in community-dwelling older adults: a retrospective cross-sectional study

Frailty is a multifactorial geriatric syndrome associated with functional decline and adverse health outcomes in older adults. Panoramic radiography is routinely performed in dental practice and enables incidental evaluation of mandibular cortical morphology without additional im...

Beyond “Picky Eating”: Identification, Screening, and Referral for Pediatric Feeding Disorders in Primary Care

Pediatric feeding disorders (PFDs) affect 1 in 37 children under age 5 in the United States, representing a common yet frequently underrecognized condition in primary care. In 2019, a multidisciplinary expert panel established the first consensus definition of PFD, creating a sta...

Cohort-level discrepancy between observed and model-based pedicle screw loosening risk: an exploratory aggregate-data evaluation of the explanatory gap index

Published pedicle screw loosening (PSL) cohorts differ substantially in observed event rates, predictor measurement, surgical context, and outcome ascertainment. We evaluated whether an aggregate discrepancy index can describe how far an observed cohort result lies from a common...

Real-Augmented Mixed Training for Wheel-Flat Geometry Classification under Data Scarcity on a Laboratory-Scale Test Rig

Accurate defect classification requires sufficient data; however, early-stage studies often face data scarcity when acquiring data through field measurements. This paper proposes a real-augmented mixed training strategy on a 3D-printed, laboratory-scale railway test rig for wheel...

Transforming Chemical Safety Policy in the AI Era: A Seven-Action Strategy for the Five Chemical Safety Acts Under the Ministry of Climate, Energy, and Environment

Chemical safety in the Republic of Korea is governed by five acts falling under the purview of the Ministry of Climate, Energy, and Environment (MCEE): the Act on Registration and Evaluation of Chemicals (K-REACH Act), the Chemicals Control Act (CCA), the Environmental Health Act...