Research works

Long-Term Outcomes and Paired Immune and Genomic Exploratory Analyses After Neoadjuvant Dose-Dense MVAC in Muscle-Invasive Bladder Cancer: A Single-Centre Case Series

Background/Objectives: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy has been the standard of care for muscle-invasive bladder cancer (MIBC) for two decades, yet a substantial proportion of patients derive no benefit. As antibody–drug conjugates an...

Real-Time Leader-Follower UGV-UAV Cooperation: Experimental Validation and Control Analysis

Abstract This paper presents the experimental validation of a real-time leader–follower cooperative control architecture for a heterogeneous system composed of a differential-drive Unmanned Ground Vehicle (UGV) and a quadrotor Unmanned Aerial Vehicle (UAV). In the proposed framew...

Suppressing phosphatidylserine externalization overcomes cancer immune evasion and enhances immunotherapy

Abstract Immune checkpoint blockade (ICB) has transformed cancer therapy, yet many tumors remain refractory to treatment due to diverse immune evasion mechanisms. To uncover novel drivers of ICB resistance, we performed an in vivo CRISPR-Cas9 screen in mice with increasing levels...

Lack of evidence for gene-level convergence linked to evolutionary shifts in torpor among placental mammals

Torpor is a key survival strategy that many avian and mammalian lineages evolved in response to challenging environmental conditions. Whether the independent evolution of torpor in different lineages involved changes in the same genes remains poorly understood. Here, we performed...

Acute and Prolonged Effects of Sweeteners and Sweetness Enhancers on Postprandial Substrate Oxidation, Energy Expenditure, Glucose, and Insulin in Humans—A SWEET Sub-Study

Background/Objectives: Sweeteners and sweetness enhancers (S&SEs) have been proposed to impair energy metabolism acutely and over time. Methods: This sub-study investigated the acute effects of a mixture of acesulfame potassium and cyclamate (Ace-K/Cyc) versus water on postprandi...

A Deep Learning-Driven Binocular Vision Path Detection Approach for Orchard Robots

Autonomous driving relying on visual navigation plays a vital role in promoting automation within the jujube industry. Conventional visual navigation strategies fail to satisfy the demands of straddle-type jujube harvesters owing to their unique row-straddling configuration and c...

Deepfakes, Electoral Integrity, and Constitutional Democracy: Rethinking Freedom of Expression in the Digital Era

The rapid advancement of artificial intelligence has enabled the creation and dissemination of highly realistic deepfake content, creating significant challenges for electoral integrity and constitutional democracy. This paper critically examines the impact of deepfakes on democr...

Extreme Hydrological Events and Lake-Wetland Landscape Dynamics: Toward Adaptive Management in Large Freshwater Systems-Insights from Poyang Lake, China

Extreme hydrological events induced by climate change pose significant challenges to the ecological stability of river-connected lake-wetland systems. Poyang Lake, China’s largest freshwater lake, provides an ideal case for investigating landscape responses to compound drought an...

Reshaping Chloride Exclusion in Stern Layer to Enable Durable Seawater Electrolysis

ABSTRACT Direct seawater electrolysis offers a promising route for green hydrogen by utilizing marine resources and offshore renewables, but is hindered by chloride‐induced corrosion and poor catalyst durability. Herein, the Helmholtz plane microenvironment is reshaped by in situ...

CBAM-YOLOv11 and Geometric Constraint-Enhanced PnP for High-Precision EV Charging Port Pose Estimation

The precise detection and pose estimation of electric vehicle (EV) charging ports in unstructured outdoor environments remain challenging due to small sizes, variable illumination, and stringent tolerance requirements for robotic plug-in operations. To address these issues, this...

Strategic Documents Shaping Russia’s Digital Project Development

Digitalization is an ongoing global process. The digitalization of the economy and public administration makes it necessary to identify specific prospects for digital development, and strategic planning documents can serve as a key driving factor. This article describes the strat...

Transport infrastructure and health equity among older adults: evidence from a quasi-natural experiment on high-speed rail in China

Against the backdrop of rapid population aging, large-scale intercity transportation infrastructure not only improves regional accessibility but also reshapes patterns of resource distribution and social interaction, thereby influencing the health and health equity of older adult...

Digital Oasis: How does digital-real integration improve corporate green governance?

The deep integration of the digital economy and the real economy at the technological level has not only reshaped the production organization modes and resource allocation logic of traditional manufacturing enterprises, but also provided new pathways for enhancing corporate green...

Optimization of China’s Urban Waste Sorting Policy Pathways from the Public Perspective Under a Multi-Party Cooperation Framework

China has experienced rapid growth in municipal solid waste generation, highlighting the need to improve the effectiveness of waste sorting governance in urban areas. As the implementation of MSW sorting policies relies heavily on public acceptance and sustained participation, ev...

Sexualization, Compromise, and Bodily Strain: The Hidden Gender Labor Practices of Female Game Companions

ABSTRACT China's esports game companion industry has evolved from informal companion game practices into a distinctive form of digital labor that combines technical performance with emotionalized and gendered expectations. This article examines the concealed forms of labor embedd...

Bacterial Pneumonia in Horses: Insights from a 10-Year European Single-Centre Retrospective Study

Bacterial pneumonia in horses typically occurs secondary to predisposing factors that compromise defence mechanisms. This 10-year retrospective study evaluated bacterial pneumonia in 81 horses treated at the equine clinic of Freie Universität Berlin from January 2015 to December...

Lightweight CNN-Based Computer Vision for Early Detection of Monilinia spp. and Taphrina deformans in Peach Crops Under Real Field Conditions

Brown Rot (Monilinia spp.) and Leaf Curl (Taphrina deformans) are principal fungal diseases affecting peach (Prunus persica L. Batsch) production, lacking validated AI-based diagnostic tools in tropical highland orchards. This study presents a compact Convolutional Neural Network...

Structural Performance of Hybrid Fiber–Metal Laminates Reinforced With Natural and Synthetic Fibers: Tensile, Dynamic–Mechanical, and Residual Stress Behavior

ABSTRACT This work studied how hybridization between natural and synthetic fibers influences the structural tensile performance, viscoelastic response, and residual stress distribution in fiber–metal laminates (FMLs). Two groups of laminates were produced: (i) fiber‐reinforced po...

Finite-horizon ratcheting with perpetual commitment: optimal consumption, investment, and lock-in effects

Abstract We study optimal consumption and portfolio policies for an agent with a finite planning horizon and an irreversible consumption ratcheting constraint. During the planning horizon, the agent may increase consumption but cannot reduce it. After the terminal date, the consu...

Next-Generation Biosensing Technologies for Environmental Monitoring, Food Protection, and Industrial Bioprocess Management

Biosensors are increasingly important in the detection of biological and chemical targets in real time, in a sensitive and selective manner, for environmental monitoring, food safety and industrial applications. Their effectiveness requires precision design of elements such as bi...