Research works

Lipopolysaccharide and cytokine levels differ by disease severity in major depressive disorder

Abstract Background Major depressive disorder (MDD) lacks established biological markers, although immune dysregulation and gut-derived inflammation have been implicated in a subset of patients; however, their diagnostic utility across levels of depression severity and impact of...

Tertiary lymphoid structures in cancer: their development, composition, clinical prognosis, and the drivers of the anti-tumor responses

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates formed under chronic inflammatory tumor microenvironments. Clinical cohorts across solid cancers demonstrate that mature TLS with intact germinal centers serve as independent favorable prognostic biomarkers and pr...

UAV-Satellite Integration Reveals Continuous Methane Emission Variability from Chinese Coal Mine Ventilation Shafts

Abstract Satellite quantification of coal mine methane lacks validation for continuously operating ventilation systems with high temporal variability. We integrate 75 unmanned aerial vehicle (UAV) flights (30 successful, 13 days) with 6.5 years of satellite observations at a Chin...

Biomacromolecular Interactions, Cytotoxicity, and Theoretical Studies of Aldimine-Based Vanadyl Complexes

Abstract Four vanadyl complexes (1–4) based on methyl, nitro, chloro, and fluoro-substituted aldimine ligands, respectively, have been designed, and the structures and geometries are optimized through DFT studies. The interactions of the complexes with DNA, as per UV absorption t...

Does corporate green investment matter? Evidence from biodiversity conservation

Purpose Biodiversity conservation is essential for corporate sustainability, yet empirical evidence on the relationship between firm-level green commitment and biodiversity exposure remains limited. This study aims to examine the relationship between corporate green investment an...

Cryptography and Optical Imaging as Dual Scattering Processes: A Categorical Formulation

This work formulates cryptography and optical imaging as dual scattering processes, modeling encryption, decryption, and imaging through scattering, Fourier duality, and anticommutation within a unified categorical framework.

Zwitterionic Copolymer-Modified Mesoporous Silica Material: A Promising Adsorbent for Both Anionic and Cationic Dye Removal and an Efficient Stationary Phase for Liquid Chromatography

Abstract The creation of innovative single materials with a variety of applications is a major need for materials in the future. The decolorization of both anionic and cationic dye-contaminated water with high adsorption capacities is one of the most challenging problems for the...

Advanced chronic kidney disease in children with CAKUT: a retrospective cohort study in Senegal

Abstract Background Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of chronic kidney disease (CKD) in children worldwide. In low-resource settings, delayed diagnosis and limited access to specialized nephrological and surgical care may increase...

Machine Learning-Assisted Nanozyme–Porphyrin Dual-Channel Sensor Array for Glycosaminoglycan Pattern Recognition

Abstract Selective discrimination of glycosaminoglycans (GAGs) is crucial for drug safety and quality control but remains challenging because GAGs share similar disaccharide repeating units and overlapping polyanionic features. Nanozyme-based sensor arrays offer a cross-reactive...

Discovery and Characterization of a Novel Ligand-Binding Site in UFC1 Using Sulfa- and Sulfonate-Based Compounds

Abstract UFMylation is an important biological process where proteins are post-translationally modified via the covalent attachment of the ubiquitin-like modifier (UBL), ubiquitin-fold modifier-1 (UFM1). UFMylation is analogous to ubiquitination, occurring via the transfer of UFM...

From Armouring to Awareness: A Somatic Case Study of Emotional Neglect and Meeting the “Black Hole” Within

This article presents a synthesised clinical and theoretical exploration of using touch-based somatic psychotherapy to address the embodied imprints of developmental trauma in adult clients. Specifically, it investigates the subtle, pervasive impact of early emotional neglect cha...

Bi‑Tempo Poset

A bi‑tempo poset equips a partial order with two monotone endofunctors and a natural transformation encoding their interaction. Synchronization, asynchrony, and leap behavior arise from invertibility or failure of naturality.

Nanoparticle accumulation in the lymph node is impaired in aged mice

Abstract Vaccine responses are impaired in aged mice and older people. A key first step in mounting successful responses to vaccines is for antigens to access the draining lymph node from the site of injection. Here we tested the hypothesis that nanoparticle drainage to the lymph...

From Founder Dependency to Institutional Capacity: A Framework for Sustainable Organization Building

Organizations often begin around the knowledge, judgment, relationships, and direct involvement of their founders. While founder centrality can accelerate early-stage execution, prolonged dependence on a single individual can become a structural constraint on scale, continuity, a...

Core-Regenerating Atom-Pair Exchange Enables Skeletal Carbon Isotope Incorporation into Pyridines

Abstract We report a core-regenerating atom pair exchange strategy for skeletal carbon isotope incorporation into pyridines. The two-step sequence proceeds through pyridine dearomatization followed by a [4 + 2]/retro-[4 + 2] cycloaddition cascade with an isotope-labeled sulfonyl...

Thick and Thin Globality: A Categorical Interpretation via Dictionary Sheaves and Sparse Selection

This paper contrasts thick globality from colimit gluing with thin globality from sparse selection in dictionary sheaves. We formalize selection as a right adjoint and show L1 regularization realizes this structure.

MORPHOLOGICAL CHARACTERISTICS OF REPARATIVE OSTEOGENESIS UNDER CONDITIONS OF CHRONIC LEAD INTOXICATION DURING PHARMACOLOGICAL CORRECTION IN AN EXPERIMENT

Aim — to assess the effect of combined metabolic correction (succinic acid, calcium citrate, vitamin D₃) on the morphological dynamics of reparative osteogenesis under ongoing lead intoxication. Materials and methods. Fifteen rats of experimental group II received water with lead...

Targeting Latent Tuberculosis Using Hypoxia-Activated Prodrugs of Bedaquiline Analogues

Abstract The increasing emergence of antimicrobial resistance (AMR) is reducing the effectiveness of existing antibiotics against bacterial infections, including tuberculosis (TB), a deadly disease caused by Mycobacterium tuberculosis (M.tb). Approximately 90% of infected individ...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

From Founder Dependency to Institutional Capacity: A Framework for Sustainable Organization Building

Organizations often begin around the knowledge, judgment, relationships, and direct involvement of their founders. While founder centrality can accelerate early-stage execution, prolonged dependence on a single individual can become a structural constraint on scale, continuity, a...