Research works

A decade later: a longitudinal retrospective cohort study of the clinical course of childhood-onset epilepsy in a multi-ethnic tertiary centre

Abstract Background Epilepsy affects a significant proportion of people globally, with many cases beginning in childhood. However, there is a lack of longitudinal studies exploring the long-term outcomes and characteristics of childhood-onset epilepsy into adulthood. This study a...

PSMA PET/CT-guided salvage elective nodal radiotherapy for nodal metastases after radical prostatectomy: a bi-institutional long-term outcome analysis

PURPOSE: PSMA PET/CT has transformed the detection of nodal recurrence after radical prostatectomy, yet real-world evidence on long-term outcomes of PSMA PET/CT-guided salvage elective nodal radiotherapy (ENRT) remains limited. This study evaluated oncological outcomes of PSMA PE...

The Translocation of Circular DNA with Variable Single/Double Strand Ratios through Solid-State Nanopores: Transition from Entropic Barriers to Crowding-Dominated Kinetics

Solid-state nanopores serve as powerful single-molecule analytical platforms for characterizing the physicochemical signatures of nucleic acids and proteins, yet prior work has focused almost exclusively on linear DNA, leaving circular DNA translocation poorly understood, particu...

Cryptography and Optical Imaging as Dual Scattering Processes: A Categorical Formulation

This work formulates cryptography and optical imaging as dual scattering processes, modeling encryption, decryption, and imaging through scattering, Fourier duality, and anticommutation within a unified categorical framework.

A formal finite-size spectral-map hierarchy for free-fermion entanglement

This record contains the preprint and the complete reproducibility package for “A formal finite-size spectral-map hierarchy for free-fermion entanglement”. The work studies the finite-size deformation of the spectral relation between the discrete prolate (Slepian) eigenvalue and...

A Conjecture of MatterJianzi Theory——A Unified Derivation of the Equations of Modern Physics

Starting from the fundamental equations of Jianzi Theory, this paper systematically derives the core equation systems of modern physics. The derivation introduces no external assumptions; it proceeds solely by applying limit conditions to the fundamental quantities of Jianzi Theo...

Countering Evolutionary Mismatch: A Targeted Bioenergetic and Circadian Protocol for Prefrontal Cortical Fatigue and Sensory Overload in Modern Environments

The human central nervous system evolved under ancestral selective pressures character-ized by cyclical diurnal solar irradiance, natural spectral filtering, high physical expenditure,and episodic rather than continuous demands on executive cognitive control. In sharpcontrast, mo...

Log-concavity of Reduced Composition Polynomials via Adjacent B-spline Refinement Columns

Ardila and Doker associated a reduced composition polynomial f_c(q) with every positive integer composition c and asked whether its coefficient sequence is unimodal or, more strongly, log-concave. We prove that the coefficient sequence is log-concave for every positive integer co...

Trends in GLP-1 Receptor Agonist Prescriptions for Children Ages 8 to 11 With Obesity: 2019–2026

BACKGROUND AND OBJECTIVES: Clinical practice guidelines for pediatric obesity management allow for consideration of glucagon-like peptide-1 receptor agonists (GLP-1RA) in children ages 8-11. No study has documented secular trends in GLP-1RA prescribing in this group. We hypothesi...

Core–Shell Nanofibrous Membranes for Dynamic Intestinal Organ-on-a-Chip Culture

Abstract Organ-on-a-chip (OOC) systems rely on membrane-supported tissue interfaces to replicate organ-level barrier functions in vitro. However, conventional porous membranes often provide limited biological cues for cell adhesion and may require an extracellular matrix coating....

Artificial density distribution in the N(1440) Roper radial excitation transition current structure

This study employs Patterson function analysis to reconstruct the spatial distribution of the N(1440) Roper radial excitation transition current. By combining empirical Dirac (F₁) and Pauli (F₂) form factors, the method reveals that the contribution of F₂ is comparatively minor....

PFUSRC‑172: Different Paths, Same Destination — The Topological Unification of Religious God‑Creation and Scientific God‑Creation, and the Encounter of Two Super Wisdom Condensates

Humanity has always been creating gods. In the past, through belief; now, through algorithms. The two paths differ in method but share the same destination — both form super wisdom condensates. This paper completes the topological unification of the two god‑creation paths within...

AI-Driven Sustainability in Industry 5.0: The Role of Responsible Leadership

Abstract As Industry 5.0 advances, artificial intelligence (AI) is increasingly positioned as a driver of sustainability in knowledge-based economies; however, empirical outcomes remain uneven and frequently symbolic. Addressing this paradox, this paper examines AI-driven sustain...

Monolithically Integrated IGZO Synaptic Transistors on a Silicon Nitride Waveguide for Optoelectronic Neuromorphic Computing

Abstract We report the first demonstration of monolithically integrated amorphous indium–gallium–zinc oxide (IGZO) synaptic transistors on a silicon nitride (Si3N4) waveguide, enabling direct on-chip optical programming by using guided 532 nm light. In this architecture, the evan...

Iteration of Complexity and Asymptotic Analysis of Gradient-Type Methods with Non-monotone Line Search on Riemannian Manifolds

Abstract This paper investigates gradient-type methods for solving optimization problems on Riemannian manifolds. In this approach, we utilize a search direction based on the gradient direction and employ a general non-monotone line search scheme to determine the stepsize at each...

Effects of planting density and topping time on the source-sink tributes and photosynthetic carbon production in short-fruiting branch cotton

Abstract Background Short fruiting branch cotton (SFBC) has normal main-stem growth. However, the growth of fruiting branches is compromised by a short sympodial internode of 2–5 cm, which is suitable for a high-density cropping system. Increasing plant population density (PPD) c...

Metal artifact reduction sequence MRI in hip periprosthetic joint infection management

Aims: There is currently no validated noninvasive method to determine infection control prior to prosthesis reimplantation during the two-stage revision process for hip periprosthetic joint infections (PJI) after total hip arthroplasty (THA). This prospective study investigates w...

Molecular Design for the Multidimensional Modulation of Supramolecular Nanoparticle Interactions

Abstract Surface ligand engineering based on reversible supramolecular hydrogen bonding provides a versatile strategy for programmable nanoparticle (NP) self-assembly, yet quantitatively linking the molecular structure to interparticle interactions remains challenging. Here, expl...

Research on climate effects of large herbivores in Europe: a systematic map

Abstract Background Land management practices have significant impacts on biodiversity and climate change processes. Conservation and rewilding practitioners are increasingly seeking to enhance ecosystem functions and carbon sequestration simultaneously, encouraged by climate pol...

Effect of a sodium fluoride rinse on the composition of early oral biofilms formed in situ on enamel and dentine

OBJECTIVES: Dental caries results from dysbiotic shifts in the microbial community, so modulating biofilm composition represents a valid preventive strategy. The aim of this double-blind randomized crossover in situ study was to investigate how a fluoride rinse can modify the com...