Research works

Real-time railhead friction estimation using machine learning: development of an on-board-train data capture system

Low adhesion between the wheel and rail interface remains a significant challenge for the railway industry, particularly during the autumn season, leading to delays and safety risks such as station overruns and signals passed at danger (SPADs). The impact of low adhesion is estim...

Prognostic significance of ACADL and MCM2 in meningiomas: Current evidence and clinical implications.

-wildtype, hypermetabolic, and proliferative. The latter two groups have the worst clinical outcomes and are enriched in ACADL and MCM2 expression, suggesting their potential as immunohistochemical surrogates. The revision of the current literature on the expression of these mark...

Fast Field Mapping of Large Size Bulk Superconductors at Variable Temperatures and Magnetic Fields

The authors thank Carnot ICEEL and the CAPMAT project (co-funded by FEDER-FSE Lorraine et Massif des Vosges 2014-2020) for their support and acknowledge Quentin Nouailhetas (now at Tokamak Energy, UK) for helping in the design of the sample holder.

Aldose reductase as a regulator of ocular pathology: Mechanisms and therapeutic potential.

Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, converts glucose to sorbitol using NADPH and becomes markedly overactive under hyperglycemic conditions. Its widespread expression in ocular tissues links AR to numerous eye disorders through sorbitol accumula...

Squamous papilloma of the external ear in Southwest China: A large case series highlighting predominant HPV subtypes, pathologic features, and unique epidemiologic factors.

Squamous papilloma (SP) of the external ear is a rare benign neoplasm, with limited research on its associated human papillomavirus (HPV) infections and pathologic features. This study aims to provide a comprehensive analysis of the largest case series of external ear SP from Sou...

CD34+ cells contribute to cardiac remodeling during disease development.

cell enrichment toward lineage-specific therapeutic strategies.

Clinical-histological and genetic features of rare variants of melanoma.

Melanoma is traditionally classified into a limited number of common clinicopathologic subtypes; however, routine clinical and histopathologic practice reveals a broad spectrum of rare variants and unusual morphologic patterns that pose significant diagnostic and therapeutic chal...

LLM-based early rumor detection with imitation agent

Early Rumor Detection (EARD) aims to identify the earliest point at which a claim can be accurately classified based on a sequence of social media posts. This is especially challenging in data-scarce settings. While Large Language Models (LLMs) perform well in few-shot NLP tasks,...

Naoluotong granules inhibit necroptosis of neural cells and improve cerebral ischemia-reperfusion injury by regulating the RIP1/NIK/IKKα/NF-κB pathway.

BACKGROUND: Cerebral ischemia-reperfusion can cause structural changes in brain tissue and disrupt physiological functions. Naoluotong granules (NLT) exhibit significant neuroprotective effects on brain nerve cells and are widely utilized in treating cerebral ischemia-reperfusion...

Experimental full-field investigation of stress development in austenite during the thermally-activated transformation of a Cu-Al-Ni single crystal

The paper presents an experimental analysis of the stress field developing within austenite in a Cu-Al-Ni single crystal during its thermally-activated transformation to martensite. Starting from a virgin sample in austenitic state, fifty homogeneous cooling-heating cycles allowe...

Astragalus polysaccharide protects against neuron degeneration and mitochondrial dysfunction in Parkinson's disease by upregulating CEND1.

BACKGROUND: possesses antioxidant, anti-inflammatory, and neuroprotective properties. APS was previously revealed to exert neuroprotective effects in experimental PD models. However, the underlying mechanism remains poorly understood. Therefore, our study was designed to reveal t...

Self-criticism and dependency in adolescents with depression: associations with clinical features and psychological functioning

Objectives: The personality dimensions of self-criticism and dependency have been shown to confer vulnerability to depression, and psychopathology more broadly, in adults. However, evidence for the roles of these personality dimensions in young people is weaker, particularly beca...

Arithmetic Holonomy and Non-Integrable Accumulation as a Structural Origin of GUE Statistics in the Zeros of the Riemann Zeta Function

The non-trivial zeros of the Riemann zeta function exhibit universal statistical properties consistent with the Gaussian Unitary Ensemble (GUE), including level repulsion and spectral rigidity. While this behavior is often interpreted through the conjectural existence of a chaoti...

On a class of Sobolev tests for symmetry of directions, their detection thresholds, and asymptotic powers

info:eu-repo/semantics/inPress

Transgenerational chromosome repair in the asexual bdelloid rotifer Adineta vaga

Homologous recombination is an essential DNA repair mechanism that also promotes chromosome pairing and ensures allele segregation during meiosis in sexual organisms. Here, we explore the dual function of homologous recombination in the bdelloid rotifer Adineta vaga, an ancient a...

Concurrently fading away and strengthening: a cross-country comparison of foreign and local news beats

One of the structuring logics behind the creation of news beats is the geographical one: that is, national, foreign and local news desks. Foreign and local beats, in particular, have a lot in common: the coverage of different geographical contexts increases the diversity and plur...

Analysts Forecasts: The Secret Sauce Stirring Up CEOs’ Abnormal Pay

Jensen and Meckling (1976) claim that by facilitating firms’ activity monitoring, security analysis by financial analysts can reduce agency costs between management and external capital providers, and thereby increase shareholder value. Additionally, boards are required to design...

Deciphering teleost testis development throughout the annual cycle: Insights from transcriptomic features and thyroid hormone signaling pathway.

Testis development and spermatogenesis in adult teleosts are seasonally regulated throughout the annual reproductive cycle, with notable changes occurring in cellular composition and molecular characteristics. However, the molecular mechanisms underlying this process are not full...

Cu2O-modified magnetic iron-nitrogen co-doped biochar effective peroxymonosulfate activation for degradation of phthalate esters in reclaimed water.

O/Fe-N-BC/PMS system demonstrated excellent stability and reusability, offering a promising approach for the treatment of wastewater contaminated with organic pollutants. This system operates efficiently under neutral conditions, is energy-effective, and addresses limitations com...

Asiatic acid alleviates dexamethasone-induced muscle atrophy through regulating the Sirt1/PGC-1α/FOXO3 pathway.

BACKGROUND: Skeletal muscle atrophy, which results in muscular dysfunction and weakness, is associated with various factors, including aging, sepsis, chronic diseases, and long-term glucocorticoid therapy. Although asiatic acid exhibits multiple biological activities and can acti...