Research works

Growth Is Not Survival Two Readings of One Function, and the Opposite Effects of Concentration

Abstract Economic and policy discussion often treats growth as a proxy for survival: as long as the aggregate is rising, the system is taken to be healthy. This paper argues that growth and survival are two readings of one function and can move in opposite directions. Let the one...

Isocoumarin Ring Rearrangement Approach to π-Extended Dibenzothiophenes

Sulfur-functionalized isocoumarins have been successfully converted into 1,2,3,4-tetrasubstituted naphthalenes through the addition of ketene silyl acetals and the subsequent skeletal rearrangement triggered by fluoride. The densely and consecutively substituted structures of the...

SpectralMol: Spectral Graph Bisection Achieves Universal Molecular Fragment Decomposition for Drug-Like Molecule Generation

Abstract Generating valid, diverse, and drug-like molecules remains a central challenge in computational drug discovery. A key bottleneck for fragment-based generative models is decomposition coverage: existing junction-tree methods fail on bridged bicyclic and spiro ring systems...

Parental Refusal of the Best Treatment: Nudges and Trust in Pediatrics

More effective and less toxic therapies are welcomed by clinicians and families and are the rationale and raison d'être for well-designed clinical trials. This is especially true for life-threatening diseases like childhood cancer. When parents opt for an existing and good treatm...

Active Blood Cell Capture and Synergistic Coassembly: Self-Gelling Gelatin-Polysaccharide Powders for Rapid Hemostasis

While effective for irregular wounds, traditional hemostatic powders often lack posthydration cross-linking, yielding fragile barriers susceptible to washout under high-pressure hemorrhage. To address this, a novel self-gelling composite powder (GOQL) was developed by incorporati...

VEGF pathway signalling across pulmonary neuroendocrine tumours: associations with histological subtypes in a multicentre study

Abstract The current classification of pulmonary neuroendocrine neoplasms (NENs) is primarily based on histomorphological criteria, which do not fully capture their underlying biological heterogeneity. This limitation is particularly evident among pulmonary carcinoids, a subgroup...

Societal Neural Networks: Governance-Aware Adaptive Coordination among Human, AI, and Institutional Actors

The metaphor of society as a neural network is not new. Prior research has modeled human society using neural-network and Boltzmann-machine analogies, while newer work on society-in-the-loop governance, institutional AI, human-AI coordination, and AI-orchestrated organizations ha...

N -Acyl Hemiperaminals: From Bioactive Skeleton Editing of Artemisinin to Programmable Handles for α-Amido Functionalization and Bioactive Peroxides

Abstract Late-stage molecular editing is vital for drug diversification and SAR studies. However, programmable peroxide-based editing handles for amides, α-amino acids, peptide- and drug-relevant scaffolds remain largely unexplored, particularly N-acyl hemiperaminals. Inspired by...

Human-AI Decision Support: Cost Structure of Explanation-Centric Workflows

Research article: Human-AI Decision Support: Cost Structure of Explanation-Centric Workflows

Macrophage-derived MMP14 fosters immunosuppressive tumor microenvironment by regulating soluble semaphorin 4D

Abstract High expression of semaphorin 4D (SEMA4D) in tumor cells fosters an immunosuppressive tumor microenvironment (TME), yet the underlying tumor-macrophage crosstalk remains poorly understood. Here, we investigated this regulatory axis using in vitro co-cultures and SEMA4D g...

Quantum Integer Torsion in the Skein Module of a Connected Sum of Two Solid Tori

We extract an explicit infinite family of torsion elements from the two-solid-torus presentation of Bakshi, Le and Przytycki. Over R=Z[q,q^{-1}], put B=R[x_1,x_2] and [m]=(q^{2m}-q^{-2m})/(q^2-q^{-2}). For every m>=2 we construct an element whose exact B-annihilator is ([m]), and...

The Triad of Structural Immunities: A Theoretical Framework for Preventing Cascading Failures, Authority Creep, and Alert Storms in Fractal Edge AI

Edge AI and modern decentralized systems increasingly rely on multi-layer hierarchical architectures, such as fractal governance models, to scale operations across distributed environments. Existing distributed protocols such as Raft, Paxos, or application-level circuit breakers,...

Biocompatible Self-assembly Coating for Safe Hair Dyes with Antimicrobial and Antiadhesion Potential

Abstract Hair dyeing has emerged as an integral part of the cosmetic industry, driving the demand for natural, safer, and malodor-free alternatives to traditional p-phenylenediamine-based hair dyes. Herein, leveraging the deposition capability of plant-derived quinones on substra...

The fixed space of the ribbon-to-homogeneous transition matrix of noncommutative symmetric functions: a proof of a conjecture recorded by J. M. Campbell

We prove a conjecture recorded by J. M. Campbell in 2018 in the OEIS entry A001405 (the central binomial coefficients binomial(n, floor(n/2))). Let NSym be the algebra of noncommutative symmetric functions of Gelfand, Krob, Lascoux, Leclerc, Retakh and Thibon, and let C_n(R, H) b...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Embedding sustainability in higher education through a Motivation–Management–Leadership framework based on bibliometric analysis

Abstract While education is a recognised driver of the UN Sustainable Development Goals (SDGs), a significant implementation gap remains in translating sustainability concepts into student engagement and behavioural change. This study systematically maps the intellectual landscap...

Drug-Initiated Synthesis and Processing of Mupirocin–PLGA Conjugates for Biodegradable Antibacterial Scaffolds

Abstract Mupirocin–poly(lactic-co-glycolic acid) (Mup-PLGA) conjugates were developed via drug-initiated ring-opening polymerization to create biodegradable scaffolds with local antibacterial activity. Conjugate composition and molecular weight were controlled to tune degradation...

A Study of Two Sister Silver Coins and the Memories They Evoke —Honoring My Mother, Zhu Xiuyu, and My Two Elder Brothers through Prose and Poetry: A Chapter in Our Family's Coin-Collecting History《一對姊妹銀幣的研究與追憶 --以詩文紀念母親朱秀毓夫人與兩位兄長,記一段家族集幣史》

Wang, Lawrence K. 王抗曝 (2026), "A Study of Two Sister Silver Coins and the Memories They Evoke —Honoring My Mother, Zhu Xiuyu, and My Two Elder Brothers through Prose and Poetry: A Chapter in Our Family's Coin-Collecting History"《一對姊妹銀幣的研究與追憶 --以詩文 紀念母親朱秀...

Exploring the Association of Injury and Disaster among Older Adults in India: Insight from the Longitudinal Ageing Study in India (LASI), 2017-18

Abstract Introduction Disasters represent an important public health concern for middle-aged and older adults, particularly in low- and middle-income countries where population ageing and disaster risks are increasing simultaneously. Although previous studies have examined the he...

Exact State-Ranked Array-RQMC: Representations and Shared Work

Repeated states in state-ranked Array-RQMC receive rank-specific inputs. We execute the reranked population without visiting every particle when complete states repeat and transitions admit short finite-word interval partitions. Primal image-basis and dual constraint counters pre...