Research works

Development of NanoBRET Cellular Target Engagement Assays in Primary Neurons for Activating Mutants of p21-Activated Kinase 1

Abstract The p21-activated kinases (PAKs) are a group of serine-threonine kinases central to multiple signaling pathways that govern cell survival and proliferation. Aberrant activity of PAK1, the most well characterized member of the PAK family, drives progression of several mal...

Gender Dysphoria in a 21-Year-Old Individual Assigned Female at Birth With Intellectual Disability: A Case Report

Gender dysphoria (GD) in individuals with intellectual disability (ID) is underrecognized and poses diagnostic and ethical challenges due to communication limitations and risk of diagnostic overshadowing. We report a 21-year-old individual assigned female at birth with developmen...

New edge proposed: candle_range_ratio_breakout — E8 Intelligence Research

{ "name": "candle_range_ratio_breakout", "source": "Toby Crabel's 'Day Trading with Short Term Price Patterns and Opening Range Breakout'", "type": "entry_engine", "rule": "On the second bar after the opening range (first 30 minutes), if the current bar's range (high-low) is less...

Uniform Wehrl stability across all bosonic mode numbers: total entropy deficit controls full trace-norm distance to coherent states

Quantitative Wehrl stability is known at each fixed number of bosonic modes; the multimode results reviewed here allow dimension dependence. We prove a full-state stability theorem with one constant that works simultaneously for every finite mode count. For every $m$-mode bosonic...

Association of dietary antioxidant patterns with heart failure risk in patients with hypertension

Hypertension is a major modifiable risk factor for heart failure (HF) and contributes substantially to the cardiovascular disease burden in China. Oxidative stress and redox imbalance have been implicated in the progression from hypertension to HF. The composite dietary antioxida...

Gendered Pathways to First Imprisonment in Midlife and Later Adulthood: A Life-Course Perspective from Japan

This study extends gendered pathways research by applying a gendered life-course perspective to women’s first imprisonment in Japan. Using data from 110 women convicted of property offenses residing in a halfway house, it compared women first imprisoned before age 40 with those f...

Synergistic regulation of yield and fruit quality in plum through combined application of mycorrhizal fungi and a tri-species leaf extract bio-stimulant

Despite the established benefits of mycorrhizal fungi and botanical biostimulants, their synergistic effects on fruit crop quality and productivity remain insufficiently characterized. This study evaluated the combined application of three mycorrhizal species ( Rhizophagus irregu...

Mitochondrial genome and morphological variability of Bactrocera oleae (Diptera: Tephritidae) from an organic olive orchard in Southern Spain

Background The olive fruit fly, Bactrocera oleae , is the most damaging pest of olive production. This study aimed to characterize the intraspecific morphological variability and assemble the complete mitochondrial genome of a population from an organic olive orchard in Órgiva (G...

The group of Abelian supersymmetry transformations isomorphic to groups of superspace tetrad transformations

Through a series of papers many results in group theory have been proven. These results establish a direct link between the local gauge groups of transformations of the Standard Model and local groups of transformations of a new kind of tetrad vectors in four-dimensional Lorentzi...

PUFLAMA YOG'OCH SOZLAR IJROCHILIGIDA OHANGDORLIKNI SHAKLLANTIRISHNING ASOSIY OMILLARI

Mazkur maqolada zamonaviy puflama yog'och sozlar ijrochiligida ohangdorlikni shakllantirishning asosiy omillari nazariy va amaliy jihatdan tahlil qilinadi. Puflama yog'och sozlarda sifatli va ifodali tovush hosil qilish, nafasni to'g'ri boshqarish, artikulyatsiya, legato, frazala...

Quantitative DNA Geometry Data Absent in Search Results — E8 Intelligence Research

FINDING: The search results are mostly video titles and generic descriptions; no primary quantitative DNA measurement data (helix pitch, diameter, base-pair spacing) is provided in the extracted text. The only concrete mathematical anchor is the existence of the double helix stru...

Retrieving “Natural Religion” in Aquinas: Giving Religion Its Due in the Theology of Religions

This study reintroduces the Christian theology of religions to Thomas Aquinas’s understanding of religion as an acquired moral virtue. Aquinas’s treatment of religion as a moral virtue challenges the norm of revelation-centric theological methods across the positional spectrum. T...

Waterfront asset, vulnerability, and coastal community resilience: Case study from Bangladesh

Low-income coastal waterfront settlements are widely viewed as spaces of risk, informality, and deficit, as the assets that sustain everyday life within these perils remain underexplored in urban resilience research. Yet the role of these social, spatial, and livelihood assets in...

Parametric assessment of urban rooftop photovoltaic potential: Threshold calibration and spatial differentiation by city scale classification

Assessing the potential of urban rooftop photovoltaic (URPV) is fundamental for promoting energy transition and urban sustainability. However, existing research is often confined to potential assessments, failing to reveal the driving mechanisms and critical parameter thresholds...

The longitudinal co-development of adverse childhood experiences and child internalizing problems: Examining sociodemographic disparities

Abstract Internalizing problems are prevalent in childhood and are associated with exposure to adverse childhood experiences (ACEs); however, their co-development across childhood remains understudied. Prior research documents sociodemographic disparities (i.e., race/ethnicity, s...

A Suitable Groom: The Effect of Girl's Education on Dowry Payments

Abstract The social and economic costs of marriage for the bride represent a significant burden for low‐/middle‐income families, contributing to the disempowerment of women within their natal and marital households in multiple ways. This paper uses a large‐scale primary dataset f...

Impact of Thermal Cauterization on the Biomechanical Strength of Mesh Fixation in Porcine Skin and Avian Cartilage Models: Surgical Implications for Sacral Colpopexy

Background: Energy devices are widely used for hemostasis in pelvic reconstructive surgery; however, their thermal effects on tissue integrity at mesh fixation sites remain unclear. This study aimed to investigate the effect of bipolar cauterization on the mechanical strength of...

Electromagnetic Induction Heating-Activated Self-Healing of Asphalt Mastics with Alternative Fillers: Mechanical Recovery and Rheological Response

Electromagnetic induction heating (EIH) enables rapid thermal activation of self-healing asphalt, but the extent to which EIH susceptibility translates into a flow-capable condition, mechanical recovery, and subsequent rheological response remains insufficiently established at th...

Competing Beyond Borders: Identifying Strategic and Sustainability-Driven Success Factors for Apparel Firms in Global Markets

The international apparel market is becoming more complex and competitive, but the multidimensional, human-centred capabilities that underpin export success in institutionally constrained markets are not well understood. This paper discusses the strategies used by export-oriented...

Digital Consumer Profile: Socioeconomic and Regional Determinants of E-Commerce Participation in Ecuador

This paper examines the socioeconomic characteristics associated with e-commerce use in a dollarized economy in Latin America—Ecuador—using a large, nationally representative household survey. Using a survey-weighted logistic model that accounts for the survey’s complex sampling...