Research works

Current State of Adjuvant Hormone Therapy in Prostate Cancer and in the Management of Pelvic Nodal Recurrence: A Narrative Review

In post-prostatectomy prostate cancer, combining androgen deprivation therapy (ADT) with salvage radiotherapy (SRT) significantly improves clinical outcomes, though the absolute benefit varies based on baseline PSA, pathological risk, and treatment design. This review synthesizes...

Gender-Based Differences in the Effects of Valproate on Dose-Corrected Plasma Concentrations of Quetiapine and Its Metabolites: A Retrospective Cohort Study

BACKGROUND: This retrospective study aimed to investigate the effects of valproate on the concentration-to-dose (C/D) ratio of quetiapine and N-desalkylquetiapine. METHODS: Multiple linear regression analysis was used to identify independent factors influencing the C/D values of...

Preoperative Topical Steroid Use and Trabeculectomy Outcomes

Précis: Preoperative topical steroid use was associated with greater surgical success and thicker, less reflective bleb walls on anterior segment optical coherence tomography 1 year after trabeculectomy. Purpose: To assess the association of preoperative topical steroid administr...

Review of Sustainable Production of Biomass-Based Amines Using Advanced Heterogeneous Nanocatalysis: Recent Trends and Future Perspectives

Abstract Biomass-based amines are renewable precursors with versatile applications in pharma, agrochemical, food additive, lubricant, and polymer industries. Metal-based heterogeneous nanocatalysts have gained paramount importance for the synthesis of renewable amines due to thei...

Avant-propos

Editorial

The Impact of High-Temperature and High-Pressure Steaming Treatment on Bioactive Compounds and Antioxidant Activity in American Ginseng

Thermal processing facilitates the transformation of major ginsenosides into rare ginsenosides, thereby enhancing the bioactive molecular profile of American ginseng. This study examined the impact of 1–4 cycles of high-temperature and high-pressure steaming (HTHPS) on ginsenosid...

Patient acceptance and experience with contrast-enhanced mammography in women with a personal history of breast cancer: findings from the COMBO trial

Abstract Objectives To evaluate patient acceptance, tolerability and experience with contrast-enhanced mammography (CEM) in women with a personal history of breast cancer undergoing routine post-surgical surveillance. Materials and methods This prospective cohort study, conducted...

A neutrophil-specific GSR integrates pattern recognition receptor in pathogenesis of neonatal late-onset sepsis: evidence from artificial intelligence-driven multi-omics and clinical validation

Abstract Background Neonatal late-onset sepsis (NS) is a life-threatening condition driven by a dysregulated host response to infection, where neutrophil dysfunction plays a pivotal role. Pattern recognition receptors (PRRs), as the frontline sensors of the innate immune system,...

Subtype-Specific Efficacy of Adrenoceptor Agonists in Inhibiting Lens-Induced Myopia in Chicks

Abstract Purpose Alpha-adrenergic receptors (ARs) may potentially play a critical role in controlling myopia, with subtype-specific signalling pathways mediating distinct effects. This study systematically investigated the efficacy of three subtype-specific pharmacological agents...

Climate change may lead to larger fires, greater area burned, and more reburning across interior Alaska

Boreal forests are experiencing rapid warming, altering fire regimes and vegetation dynamics. However, projecting future fire activity remains challenging given complex interactions among climate, vegetation, and landscape features. We used the LANDIS-II forest landscape simulati...

An Integrated Workflow for Enriched 3D (e3D) Models to Support Conservation Practices in Cultural Heritage: The ChemiNova Project

The project ChemiNova, funded by the Horizon Europe program, is dedicated to the development of an integrated suite of five software modules to enhance the conservation, analysis, and monitoring of cultural heritage assets. Using non-invasive data acquisition technologies, we pro...

Momentum slip-induced free convective thermal and mass transport in Cu-water nanofluid flow: Impact of nanoparticle triboelectrification and nanoparticle volume fraction

This study investigates free convective heat and mass transport in Cu-water nanofluid flow over a wall surface, with particular emphasis on the combined effects of momentum slip, nanoparticle triboelectrification, and nanoparticle volume fraction. The novelty of the study lies in...

Aqueous extract of erigeron annuus ameliorates OVA-induced atopic dermatitis-like skin lesions through modulation of Th2-mediated immune responses and MAPK signaling

Context Atopic dermatitis is a chronic inflammatory skin disorder characterized by epidermal barrier dysfunction and dysregulated type 2 helper T cell (Th2)-mediated immune responses. Erigeron annuus (L.) Desf. is traditionally used for inflammatory conditions, but its effects on...

Cell-Penetration Peptide-Conjugated Octominin II Hybrid Inhibits the Multidrug-Resistant Shigella flexneri

Background/Objectives: The genus Shigella is one of the major pathological agents responsible for diarrhea and diarrhea-related mortality worldwide. It shows a decreasing sensitivity to most conventional antibiotics available today. Methods: Hence, an antimicrobial peptide, Octom...

Reconstruction of high-speed train bogie hunting oscillations via a CNN-BiLSTM framework

High-speed train bogie hunting waves exhibit strong nonstationary characteristics and often suffer from data loss. Traditional methods struggle to fit local transients, causing over-smoothing and information loss. To address this, a multi-scale spatio-temporal feature fusion mode...

E8 Weyl-Group Chirality Gates Govern Topological Spin Selection in Bi — E8 Intelligence Research

Building on the B3/C3 Weyl-group classification of Z₂ topological superconductors, the 240 E8 root vectors decompose into left- and right-handed chiral sub-lattices of 120 each through the long-root Weyl reflection subgroup W(E6), which embeds naturally into the spin-momentum loc...

Brønsted Acid-Catalyzed Nitroso-Diels–Alder Reaction of 2-Trifluoroacetamido-1,3-dienes

Abstract The nitroso-Diels–Alder (NDA) reaction represents a powerful strategy for the assembly of 3,6-dihydro-1,2-oxazines for nearly a century, owing to its efficiency and broad utility in synthesizing natural products and bioactive molecules. Despite these advancements, tradit...

Execution-Consistent Event-Responsive Truck–UAV Coordination Under Simulated Progressive Road Disruption

Progressively revealed road disruptions can invalidate truck–unmanned aerial vehicle (UAV) relief plans while deliveries and recovery operations are already under way. We develop ER-HLNS-PR, an event-responsive framework that reconciles realized task, vehicle, and material states...

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

The target-engagement predictor, implemented within the InSilicoTrials cloud-based, AI-powered platform for model-informed drug discovery and development, enables early exploration of time-dependent pharmacological responses. Predictions can be generated using inputs ranging from...

Ga3+ Replacing of Fe3+ as a “Trojan Horse” Antimicrobial Strategy: Modeling the Process within Bacterial Catalase–Peroxidase KatG

Abstract Replacement of Fe3+ by Ga3+ has emerged as a promising “Trojan horse” antimicrobial strategy in response to the growing threat of antibiotic-resistant bacteria. Because many bacterial proteins hijack host iron to sustain essential redox processes, substitution with redox...