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Gui Gan Shen Mai Yin attenuates cardiac hypertrophy and dysfunction in association with mitochondrial homeostasis and the PI3K/AKT1 signaling pathway

This study aimed to evaluate the effects of Gui Gan Shen Mai Yin (GGSMY) on cardiac hypertrophy and dysfunction and to explore associated mechanisms. The chemical profile of the GGSMY aqueous extract was characterized using UPLC-MS. Candidate active ingredients and potential targ...

A Flow-Field-Driven Zonal Framework for Mechanism-Based Corrosion-Hotspot Identification in Gas-Field Three-Phase Separators

Internal corrosion in gas-field separators is highly localized because flow, phase distribution, deposits, and water chemistry vary strongly over the vessel wall. This study presents a flow-field-driven zonal framework for corrosion-hotspot screening in horizontal three-phase sep...

Variable Selection for the Propensity Score Model: Beyond Main Effects and Linear Relations

ABSTRACT Propensity score methods are frequently used to estimate treatment effects in observational studies. The propensity score is usually estimated using a logistic regression model with additive and linear effects. The limited literature on variable selection for the propens...

The Evolution of Neoadjuvant Treatment for Resectable Esophageal Squamous Cell Carcinoma: Past Achievements, Current Standards, and Future Perspectives

Neoadjuvant treatment has become an integral component of multidisciplinary management for resectable esophageal squamous cell carcinoma (ESCC). Over recent decades, treatment has evolved from surgery alone to postoperative chemotherapy, neoadjuvant chemotherapy, intensified syst...

Exploring suicide bereavement experiences and support needs among muslims and individuals with an Islamic cultural background living in Australia

Suicide loss may increase the risk of posttraumatic stress disorder and suicidality. Within the Muslim community, suicide is highly stigmatized, reducing social support and increasing the risk of prolonged grief symptoms. Given the scarcity of research with this population, this...

Chanel's Lipsticks Color Trend Evolution From 1960 Until Today

ABSTRACT This study characterizes the evolution of CHANEL lipstick colors from 1960 to 2020 using complete archival color charts. Because some early lipstick specimens are no longer preserved, the suitability of the charts as proxies was evaluated by comparing 146 surviving lipst...

Surgical management of dissecting cellulitis of the scalp: a narrative review of techniques, patient selection, and integration with medical therapy

OBJECTIVE: To summarize surgical objectives, indications, technical principles, limitations and reconstructive considerations for dissecting cellulitis of the scalp (DCS), and explicitly distinguish DCS‑specific evidence from data extrapolated from hidradenitis suppurativa (HS)....

Exploring the dual mechanisms of organic fertilizers in regulating Cd bioavailability in soil: Abiotic immobilization and microbially driven processes

Cadmium (Cd) contamination in agricultural soils threatens global food safety. Organic fertilizers (OFs) are renewable soil amendments with considerable potential for regulating Cd bioavailability. However, how abiotic reactions interact with microbially mediated processes under...

Utilization of low glycemic index foods and associated factors among Type 2 Diabetes Mellitus patients in Debre Markos referral and Finote Selam hospitals, Northwest Ethiopia, 2019

Entire populations are at risk of chronic conditions such as diabetes mellitus. There are also limited resources in Ethiopia to control hyperglycemia due to high catastrophic expenditures associated with managing chronic diseases. Due to the critical importance of balancing blood...

From Evidence to Practice: A Behaviourally Informed Multidisciplinary Strategy to Increase Cefazolin Prophylaxis in Joint Arthroplasty Patients with Penicillin Allergy Labels

Background: Cefazolin is recommended for surgical prophylaxis in most patients with penicillin allergy labels (PALs) but concerns over beta-lactam cross-reactivity often limit use. We evaluated a behaviourally informed, multidisciplinary antimicrobial stewardship strategy on cefa...

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...

EuroMillions Breakthrough Mining — 10419 Sources, 101516 Leads Extracted — E8 Intelligence Research

Mined 10419 lottery+quantum breakthroughs. Extracted 101516 leads across 13 categories. 97831 high-value leads found. Categories: {"CORRIDOR": 8878, "FORMULA": 8621, "GEOMETRIC": 1718, "FORWARD_ATTEMPT": 9332, "QUANTUM": 9583, "TIMING": 657, "CELESTIAL": 8686, "GEMATRIA": 9107, "...

Conditional diffusion for single-cell Hi-C data imputation and enhancement with scHiC-Diff

Single-cell high-throughput chromosome conformation capture (scHi-C) enables the analysis of cell-to-cell variability in three-dimensional (3D) genome organization, but its utility is severely limited by pervasive technical dropouts, leading to extremely sparse contact maps. Accu...

Increase in gut microbiota taxonomic sensitivity to inflammation from 6 to 12 month infants

Inflammation is a biological response typically indicative of a diseased state, and long-term inflammation is also potentially pathological. Recent studies have highlighted the important relationship between the gut microbiota and inflammation in the human body, identifying a pot...

A finite counterexample to two best proximity point theorems in non-Archimedean generalized Menger spaces

This independent correction-note preprint examines Theorems 1 and 2 of Oumertou et al., Mathematics 14 (2026), 1443 (doi:10.3390/math14091443). A complete six-point non-Archimedean generalized Menger space and a cyclic mapping satisfy the printed hypotheses, including proximal ad...

ADSCs-Exo Attenuate HIRI in Miniature Pigs: Pharmacological Evidence for a Potential Association Between Copper-Associated Alterations and Ferroptosis-Related Responses

Hepatic ischemia–reperfusion injury (HIRI) involves multiple forms of regulated cell death, but the relationship between copper-associated alterations and ferroptosis-related responses remains incompletely understood. This study investigated whether pharmacological modulation of...

Patient-identified barriers and facilitators to maternal health care in lmics: a qualitative study in Argentina and Ethiopia

Abstract Background Ninety-nine percent of global maternity deaths occur in low-and-middle-income countries (LMICs), despite availability of high quality evidence-based guidelines for common causes of maternal mortality. An understanding of barriers and facilitators (BFs) to acce...

Phytochemical Screening and Protective Effects of Hancornia speciosa Leaf Extract Against Fatty Acid-Induced Lipotoxicity in HepG2 Cells

Hepatic steatosis is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver disease worldwide. Lipotoxicity, resulting from excessive accumulation of fatty acids and bioactive lipid intermediates, is associated with incr...

Regenerating High-Performance Lithium Iron Phosphate through Establishing a Stable Structure via Designing a Reaction Path with Easy-Transformed Intermediates

Abstract Regenerating lithium iron phosphate (LFP) from recovered lithium carbonate and iron phosphate by conventional hydrometallurgy process is challenged by high wastewater treatment cost and the unsatisfying performance of regenerated LFPs. Herein, a nanoscale LFP with enhanc...

Point/Counterpoint on the Controversial 2025–2030 Dietary Guidelines for Americans

The 2025-2030 Dietary Guidelines for Americans (DGAs) issued nutrition recommendations, some of which have been praised by the nutrition community while others have been questioned based on the lack of supporting evidence. The recommendations about calorie control, emphasis on nu...