Research works

Effects of kaempferol on oxidative stress, cytoskeletal, and cellular features in MCF-7 and MDA-MB-231 breast cancer cells

Kaempferol, a naturally occurring flavonoid found in various fruits and vegetables, has been widely studied for its biological activity; however, its cellular effects in different breast cancer cell types remain incompletely understood. This study investigated the effects of kaem...

The impact of Braun-modified single loop versus isolated Roux-en-y reconstruction on clinical outcomes following pancreaticoduodenectomy

The optimal reconstruction technique following pancreaticoduodenectomy (PD) remains a subject of debate. The objective of this study was to compare the clinical effects of isolated Roux-en-Y and Braun modified single loop (BMSL) reconstruction techniques following PD on delayed g...

The majority of 5hmC is nucleosome-associated in naïve B cells

DNA demethylation is essential for gene activation and is primarily mediated by the Ten-Eleven-Translocation (TET) dioxygenase family. TET initiates demethylation by oxidizing 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), a chemically stable derivative that is not onl...

Metagenomics reveals biogeography and functional potential of phage communities in bee gut

Bacteriophages (phages) are pivotal regulators of microbiome ecology and function, yet their distribution, diversity and ecological roles within the bee gut remain largely unexplored, particularly across diverse bee species and geographic regions. Here, we used a large-scale meta...

Optimizing Voice-Based Feature Engineering and Machine Learning Pipelines for Early Parkinson’s Disease Detection

Most voice-based Parkinson’s disease studies evaluated a narrow set of models on fixed feature spaces, which limited generalizability and obscured feature–model synergies. Many also neglected fold-wise fitting and runtime measurement, increasing the risk of data leakage and hinde...

District-level measles outbreak prediction in Bangladesh using geospatial artificial intelligence

Measles has re-emerged as a growing public health threat despite the availability of a safe and effective vaccine. In Bangladesh, recurring outbreaks and widening immunization disparities underscore the urgent need for proactive district-level risk assessment. This study develope...

Serial cardiac ultrasound in acutely ill adults: a systematic review

Background Cardiopulmonary symptoms frequently prompt emergency department (ED) visits. Serial as-sessment of dynamic cardiac ultrasound parameters may support monitoring, but their asso-ciation with patient outcomes and role in guiding management is uncertain. This systematic re...

Asphyxiating thoracic dystrophy associated with IFT74 pathogenic variant: a case report

Asphyxiating Thoracic Dystrophy (ATD) is a rare skeletal ciliopathy characterized by a constricted thoracic cage, short ribs, and pulmonary hypoplasia. While typically linked to pathogenic variants in IFT80 or DYNC2H1 , recent genomic advancements have identified biallelic varian...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...

Mathematical Model Analysis for the Transmission Dynamics of Wheat Yellow Rust Disease: In Case of Melga Woreda, Sidama Regional State, Ethiopia

In this work, we present a mathematical model that uses real data to characterize the transmission dynamics of wheat yellow rust (WYR) disease. The model’s well-posedness, such as the existence and uniqueness, the positivity, and boundedness of the solutions of the model, is exam...

Research progress on multi-mechanism analysis and protection strategies of ovarian aging and fertility decline

Age-related fertility decline is an increasingly important challenge in reproductive medicine, driven largely by progressive ovarian aging. The aging ovary undergoes functional deterioration characterized by reduced ovarian reserve and declining oocyte quality, ultimately limitin...

Stress hyperglycaemic ratio is independently associated with intramyocardial haemorrhage in STEMI patients: a cardiac magnetic resonance study

ST-segment elevation myocardial infarction (STEMI) often results in microvascular injury, including intramyocardial haemorrhage (IMH), despite successful reperfusion. This study explored whether the stress hyperglycaemic ratio (SHR) is independently associated with IMH in STEMI p...

Deep learning-based wireless channel prediction with propagation feature exploitation

Deep learning based wireless channel prediction can benefit from full exploitation of propagation features, yet how to construct effective inputs for accurate channel prediction remains under-explored. This paper presents a deep learning-based approach that optimizes environmenta...

A mixed-method in-depth study of test-specific refactorings

Unlike traditional refactorings, research on test-specific refactoring is limited. This paper presents a comprehensive catalogue of 57 test-specific refactoring types, out of which only 33 were previously documented in the literature. We have identified and classified those refac...

A spatiotemporal deep learning framework for electricity price linkage forecasting using graph attention and reinforcement learning

Medium- and long-term electricity spot-price forecasting is affected by temporal fluctuation, cross-market transmission, and unstable regional coupling, making single-market sequence models insufficient for linkage-aware prediction. This study proposes DL-GNN-LP, a spatiotemporal...

Sugar-binding protein MalE mediates cadmium immobilization and promotes biofilm formation in microbial communities

Microbial communities survive in stressful environments like cadmium (Cd) contamination through adaptive responses. Cd pollution is frequently associated with elevated zinc (Zn); however, how microorganisms utilize Zn to shape community structure remains unclear. Here, we find th...

Autoimmune glial fibrillary acidic protein astrocytopathy: a case report from Hong Kong

Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a rare autoimmune disorder first described in 2016. 1 It typically presents as acute or subacute meningitis, encephalitis, and/ or myelitis, with symptoms such as fever, cognitive decline, limb weakness, and au...

From service cues to behavioral intention: Trust formation under uncertainty in a demand-responsive transit pilot in Wuxi, China

When people encounter a novel digitally mediated service, behavioral intention may depend not only on perceived utility but also on whether service cues can be translated into trust under uncertainty. Demand-responsive transit (DRT), which combines app-based coordination with phy...

Homological dimensions via silting and tilting objects in triangulated categories

This paper investigates how classical homological invariants extend from module categories to a triangulated category T with a compact silting generator M .We construct sup-projective, inf-injective and sup-flat resolutions for objects in T , and use them to establish basic prope...

Phytochemical profiling, bioactivity and in silico studies of Capparis decidua Edgew (Forssk.) root bark extracts

Capparis decidua (Forssk.) Edgew., a perennial shrub prevalent in arid Africa and Asia, holds prominent status in Sudanese traditional medicine for inflammation, infections, and scorpion stings. Despite extensive ethnomedicinal use, particularly of root bark, comprehensive scient...