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Predicting infection risk in rheumatoid arthritis patients receiving biological or targeted synthetic disease-modifying anti-rheumatic drugs: an application of machine learning and healthcare big data

Patients with rheumatoid arthritis (RA) initiating biologic or targeted synthetic disease-modifying antirheumatic drugs (b/ts DMARDs) face elevated risk of serious infections, necessitating tools for individualized risk stratification. Primary objective was to develop and validat...

EuroMillions Breakthrough Mining — 1456 Sources, 10141 Leads Extracted — E8 Intelligence Research

Mined 1456 lottery+quantum breakthroughs. Extracted 10141 leads across 13 categories. 8234 high-value leads found. Categories: {"CORRIDOR": 832, "FORMULA": 684, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 863, "QUANTUM": 1076, "TIMING": 179, "CELESTIAL": 772, "GEMATRIA": 817, "CONSTANT"...

EuroMillions Breakthrough Mining — 1448 Sources, 10053 Leads Extracted — E8 Intelligence Research

Mined 1448 lottery+quantum breakthroughs. Extracted 10053 leads across 13 categories. 8146 high-value leads found. Categories: {"CORRIDOR": 824, "FORMULA": 676, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 855, "QUANTUM": 1068, "TIMING": 179, "CELESTIAL": 764, "GEMATRIA": 809, "CONSTANT"...

Heterologous Expression of Thanatin Using Dual Transposon System in Saccharomyces cerevisiae

Thanatin is a small cationic antimicrobial peptide with broad-spectrum antibacterial activity, considered a promising candidate to combat the global antibiotic resistance crisis. Microbial biosynthesis represents an attractive strategy for sustainable production of antimicrobial...

Geosynthetic reinforcement and drainage in fine-grained embankments under rainfall

The increasing use of locally sourced fine-grained soils in embankment construction increases susceptibility to rainfall-induced instability due to low permeability, high water retention and limited shear strength. This study investigates the coupled reinforcement–drainage behavi...

Revisitingthe LSER Approach in the Era of MachineLearning: Insights from IAM Chromatography

Abstract The present study demonstrates the integration of the linear solvation energy relationship (LSER) concept with machine learning (ML) methodologies to improve the predictive and interpretative capabilities of chromatographic retention modeling. Immobilized artificial memb...

‘Acknowledge, Not Recognise’: What a 1972 Cable Reveals About Australia's 50‐Year Taiwan Dispute

ABSTRACT In December 1972, 19 days after his election, Gough Whitlam established diplomatic relations with the People's Republic of China (PRC). The joint communiqué stated that Australia ‘acknowledges the position of the Chinese Government that Taiwan is a province of the People...

Designing Reliable Care Through Clinical Pathways: A Human Factors Framework

Background/Objectives: Healthcare delivery systems are inherently complex, and efforts to improve quality and safety often fail to achieve sustained, system-wide impact because of misalignment between work system design, care processes, and clinical practice. This article present...

Deciphering Kinetic Principles of Dual‐Anion Electrolytes for Extreme Fast‐Charging Lithium‐Ion Batteries

ABSTRACT Tailoring Li + solvation coordination has been recognized as a strategy to enhance the electrochemical performance of lithium‐ion batteries (LIBs) under extreme fast‐charging (XFC) conditions. Beyond weakening Li + solvation, increased Li–anion pairing plays a crucial ro...

Failure Analysis and Maintenance Assessment of Differential Systems in Automobile Power Transmission

The differential is one of the most critical components of an automobile power transmission system, responsible for transmitting torque from the driveshaft to the drive wheels while allowing them to rotate at different speeds during cornering. Due to continuous exposure to varyin...

EuroMillions Breakthrough Mining — 1415 Sources, 9690 Leads Extracted — E8 Intelligence Research

Mined 1415 lottery+quantum breakthroughs. Extracted 9690 leads across 13 categories. 7783 high-value leads found. Categories: {"CORRIDOR": 791, "FORMULA": 643, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 822, "QUANTUM": 1035, "TIMING": 179, "CELESTIAL": 731, "GEMATRIA": 776, "CONSTANT":...

Cybersecurity Challenges in Indian Fintech Start-Ups: A Regulatory Lens

The rapid growth of fintech start-ups in India has transformed the financial services landscape by accelerating innovation in payments, digital lending, wealth management, and insurance while promoting financial inclusion. However, this digital expansion has simultaneously expose...

Sociodemographic Development and Influencing Factors of the Global Burden of Self-Harm, 1990-2021: Findings from the Global Burden of Disease Study 2021

BACKGROUND: Self-harm is a significant global public health challenge with substantial psychological and economic impacts. This study analyzes trends in self-harm, focusing on the effects of the COVID-19 pandemic and sociodemographic index (SDI) on self-harm outcomes. We aim to e...

Perceived Social Support, Personality and Self-Esteem in Emerging Adulthood: An Integrative Review and an Agenda for Nigerian Research

This review integrates them and argues that the field's dominant measurement practices have systematically attenuated its estimates. Three claims are advanced. First, the routine use of total perceived-support scores obscures source-specific effects, and the available evidence in...

ROLES OF IMPROVISATION ON BASIC SCIENCE TEACHING IN NIGERIA

This study investigated the role played by improvisation in basic science teaching in Nigeria. Improvisation in basic science in Nigeria plays very crucial role in enhancing student engagement and understanding, especially given the challenges of limited resources. Effective teac...

Effects of serial casting on cardiac autonomic modulation in children with cerebral palsy: a single-blinded randomized controlled trial

Abstract To examine whether serial casting promotes autonomic nervous system adaptation in children with spastic CP, in comparison to ankle-foot orthoses (AFOs) and no intervention. Thirty children with spastic CP (aged 6–12 years) were randomly assigned to one of three groups: S...

Understanding current practice and challenges to the implementation of rehabilitation for people living with dementia: insights from health professionals in Malaysia

PURPOSE: To examine Malaysian health professionals' knowledge, attitudes, confidence, beliefs, and practices regarding dementia rehabilitation, and to identify perceived barriers and enablers. MATERIALS AND METHODS: An online survey assessed dementia knowledge (DKAS), attitudes (...

Facile, high‐throughput protein purification enabled by high‐efficiency protease elution

Abstract While advances in artificial intelligence have made protein design widely accessible, protein production and characterization remain a bottleneck. Protease‐cleavable affinity tags are commonly used to improve yield and purity of recombinant proteins, but tag removal adds...

BioinspiredDesign Strategies and Thermal TransportMechanisms in Thermally Conductive Composites

Abstract The rapid development of high-power-density electronics has created increasing demands for thermal management materials, making thermally conductive composites (TCCMs) important candidates for electronic packaging and related applications. Structural design is an effecti...

The Landscape of Biomarkers in ICU ‐Associated AKI : From Protein Markers to Cell‐Free Nucleic Acids

BACKGROUND: Acute kidney injury (AKI) affects approximately 30%-60% of intensive care unit (ICU) admissions, but early detection remains difficult because creatinine- and urine-output-based KDIGO criteria are delayed and confounded in critical illness. OBJECTIVE: To summarize the...