Research works

Consensus-informed design of digital case-based learning for clinical and public health reasoning in undergraduate Community Medicine: a modified Delphi study

Community Medicine requires undergraduate medical students to integrate clinical reasoning with epidemiological interpretation, the social determinants of health, national health-programme linkage and preventive decision-making. Digital case-based learning (DCBL) may support this...

Real-world performance of the breast GPA in breast cancer brain metastases in a resource limited setting

The Breast Graded Prognostic Assessment (B-GPA) is a validated prognostic score used to estimate survival in patients with breast cancer brain metastases (BCBM). However, real-world evidence assessing its prognostic accuracy, particularly in low- and middle-income countries (LMIC...

Differential associations between treatment delay and survival across head and neck cancer subsites: a national hospital-based framework for risk-stratified prioritization

Purpose Delays in time to treatment initiation (TTI) have been associated with inferior outcomes in head and neck cancer, yet prior studies have typically evaluated tumors collectively, assuming uniform time sensitivity across diseases. This study quantified subsite- and stage-sp...

Dynamics around non-spherical symmetric bodies – III. The case of a spherical body with a crater

Abstract Motivated by the peculiar features of the trans-Neptunian object (TNO) Máni and the discovery of ring systems around Centaurs and trans-Neptunian bodies, we investigate the stability of particles around a small irregular body hosting a deep equatorial crater. This study...

Engineering division of labor in microbial consortia for bioprocessing

As engineering goals in microbial bioprocessing become increasingly complex, functional programmability in single strains is often limited due to finite cellular resources and space, as well as incompatibilities among individual pathway components. Microbial division of labor (DO...

Application of microenvironment regulation in seawater electrolysis

Water scarcity remains a major constraint for sustainable hydrogen production via water electrolysis, making direct seawater electrolysis (DSE) an attractive route toward large-scale hydrogen production. However, complex interferents in real seawater, particularly Cl − , Mg 2+ an...

Chelsea critical care physical assessment tool (CPAx) for adult patients hospitalized in the ward: measurement properties

Objective To evaluate the measurement properties of the Brazilian version of the Chelsea Critical Care Physical Assessment Tool (CPAx-Br) and evaluate the evidence of validity in adult general ward patients, extending its application beyond the critical care setting for which it...

Long-term legacy effects of Eucalyptus plantation on soil properties, ant diversity, and ecosystem functioning in tropical montane ecosystems

Eucalyptus plantations are rapidly expanding across tropical mountains, where silvicultural practices modify soil properties and biodiversity. However, the long-term consequences of abandoned plantations remain poorly understood, particularly in biodiversity hotspots such as the...

European joint programme HBM4EU - Bridging science and policy: experiences and lessons learned from the key partners in the scientific steering of the initiative

The European Joint Programme HBM4EU was established to address politically relevant questions on chemical risks to public health through a targeted human biomonitoring research programme. Running from 2017 to 2022, it was co-financed by the EU's Horizon 2020 Research and Innovati...

Modulation of precession-forced Asian–African monsoon and arid climate variability by obliquity

Precession and obliquity play vital roles in orbital-scale climate change. However, their combined effects remain poorly understood. In this study, we examine how obliquity modulates precession-driven climate responses across Asian–African monsoon and arid regions (AAMAR). Result...

A novel unified loading path design method for rock dynamic and static triaxial loading: An analytical investigation

True triaxial testing technique is one of the research focuses in rock mechanics, where appropriate loading paths are critical for triaxial experiments. However, dynamic true triaxial testing remains at an early stage of development, and conventional loading procedures developed...

Hydrogen rich producer gas generation from coal Co-gasification with dual biomass feedstock in a downdraft fixed bed gasifier: Experimental study and RSM optimization

The increasing global demand for energy, driven by population growth, highlights the need for sustainable and efficient energy conversion technologies. Gasification has emerged as a promising approach for converting low-grade coal into valuable gaseous products. In this study, th...

Combining network toxicology with machine learning and experiment validation to analyze the molecular mechanism and core target screening of aristolochic acid nephropathy

Aristolochic acid nephropathy (AAN), a rapidly progressive kidney disease caused by aristolochic acid (AA), frequently progresses to end-stage renal disease and lacks effective therapy. The molecular targets that couple AA exposure to renal injury remain further defined. This stu...

Listen to my play: Decoding the narratives and emotions of sexually abused children through a mixed-methods approach

Background Child sexual abuse (CSA) is a prevalent yet underreported problem, and reliable tools for assessing its psychological impact in children remain limited. Objective This study aimed to develop narrative story stems, identify core themes in children's narratives, develop...

Spatial disparities in surf-resource sustainability: Implications for coastal policy and marine education in Taiwan

This study situates global surf sustainability within the Taiwanese context, where recreational surfing has developed since the 1980s and expanded internationally after 2010, yet region-wide assessments of surf-resource sustainability remain limited. Little is known about how sus...

Role of calcineurin B homologous protein 3 in C2C12 myogenic differentiation

Calcineurin B homologous protein 3 (CHP3), also known as tescalcin, has been implicated in the regulation of cardiomyocyte hypertrophy, but its function in skeletal muscle remains unclear. Here, we investigated the role of CHP3 in C2C12 myogenic differentiation. CHP3 expression w...

Development and validation of the HKT-PE(J): A standardized assessment for English learning difficulties

English learning difficulties (ELD) are prevalent among Chinese students learning English as a second language (ESL), yet few standardized assessment measures are available to support early identification and intervention. This study developed and validated the Hong Kong Test of...

Transgluteal Decompression of the Pudendal Nerve in Pudendal Neuralgia: Implications of Sacrospinous Ligament Resection

Objective: This study evaluated the efficacy of pudendal nerve decompression via the transgluteal approach for pudendal neuralgia and examined factors associated with surgical outcomes.Methods: Pain reduction was analyzed in 14 patients with pudendal neuralgia who underwent trans...

Discovering nominal constructions through behavioral profiles: the case of Akan

This study examines nominal constructions in Asante Twi, a variety of Akan (Niger-Congo, Kwa), using the Behavioral Profiles (BP) approach. It investigates how constructional identification can be operationalized empirically, and what taxonomy of noun phrase (NP) patterns emerges...

A narrative review of school-based preventive interventions on mental disorders and addictions

In recent years, there has been considerable concern about the deterioration of mental health in children and adolescents, and there is a coincidence between mental disorders and addictive disorders. In view of this situation, it is important to review preventive interventions fr...