Research works

Neural mechanisms of sensory over-responsivity in youth with early caregiver-related adversity

Abstract Sensory over-responsivity (SOR) is an impairing sensory processing challenge prevalent across a range of clinical and neurodevelopmental populations, as well as those with experiences of early caregiver-related adversity. Despite its prevalence and impairing nature, litt...

Neurodevelopmental outcome in children with congenital cytomegalovirus infection: a systematic review and meta-analysis protocol

Abstract Background Congenital cytomegalovirus (cCMV) infection is the most common cause of congenital infection worldwide. Neurodevelopmental sequelae have been reported in children with cCMV across different developmental stages, from infancy to adolescence. However, the eviden...

Execution Coverage Reconciliation: measuring the ungoverned surface when absence of bypass cannot be proved from inside

A governance gate that commits a hash-chained receipt in the same transaction as its determination binds determination to evidence, but binds nothing to effect: the transition occurring in the world is a separate event on a separate system the governing runtime cannot observe. Ab...

Termination under Optimal Play in the Two-Player 3n+/-1 Game

We address the two-player 3n+/-1 problem stated at https://althofer.de/collatz-prizes.html. The game is played on positive odd integers: a move replaces n > 1 by the odd part of either 3n-1 or 3n+1, and the player who reaches 1 wins. Arbitrary play need not terminate. We give a b...

Short-term inspiratory muscle training, aerobic exercise, and detraining in women with COPD: a randomized controlled trial

Abstract Background Inspiratory muscle dysfunction, exercise intolerance, dyspnea, and reduced well-being contribute to the burden of chronic obstructive pulmonary disease (COPD). We compared the short-term effects of inspiratory muscle training (IMT), aerobic exercise (AE), comb...

Isolation of Phytoecdysteroids:Ajugasterone C and20-Hydroxyecdysone, from Sida alba Linn.

Abstract Medicinal plants are employed in folk medicine as enormous reservoirs of secondary metabolites, with varied and distinctive chemical and biological properties, that can prevent, treat, or cure diseases. Consequently, the validation of traditional remedies has remained a...

1% Acetic Acid as an Effective and Cytocompatible Antimicrobial Agent with Enhanced Activity in Acellular Dermal Matrix for Wound Management

Abstract Objectives To evaluate the antimicrobial efficacy, antibiofilm activity, cytocompatibility, and biomaterial compatibility of 1% acetic acid (AA), including its application within acellular dermal matrix (ADM) for advanced wound management. Methods Antimicrobial activity...

Retention and wear assessment of novel PolyEtherKetoneKetone versus traditional cobalt chromium material used in digital double crown retained removable partial dentures

BACKGROUND: Conventional removable partial dentures (RPDs) involve a process that is often susceptible to errors and demands a significant investment of time. The introduction of computer-aided design and computer-aided manufacturing (CAD/CAM) technology and materials witnessed s...

Mitochondrial genome of invasive apple snails species

This project reports assembled mitochondrial genomes of invasive apple snails. These genome assemblies were generated to support species identification, comparative mitogenomic analyses, and studies of genetic diversity and invasion biology in apple snails.

Sirolimus-eluting balloon for the treatment of peripheral artery disease: SUCCESS PTA real-world single-arm study

BACKGROUND: Outcomes with sirolimus-coated drug-eluting balloons (DEB) have been positive for the treatment of femoropopliteal arterial lesions but have not been studied in a broader patient population. OBJECTIVES: Collect real-world safety and effectiveness data on the SELUTION...

PercolationMechanisms in Transient Polymer Networksacross Dilute and Semidilute Regimes

Abstract Percolation in transient polymer networks remains poorly understood because reversible cross-links continuously reorganize the network structure. In this study, we investigated percolation in transient polymer networks by independently controlling network connectivity an...

The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation

Abstract N-acetyltransferase 10 (NAT10) is a multifunctional enzyme that harbors RNA acetyltransferase and RNA helicase domains and has emerged as a therapeutic vulnerability in solid and hematological malignancies. By coupling Proteolysis Targeting Chimera-mediated degradation o...

Beyond Automation: Reimagining Human-Centered Systems for AI-Mediated Institutions

ABSTRACT: Artificial Intelligence, automation, and digitally driven systems are rapidly transforming modern institutions across public and private sector institutions. While these technologies promise efficiency, scalability, personalization, and operational optimization, they al...

Aerographite vsGraphite: Investigating the Role ofElectrode Architecture in H2-Mediated ElectroautotrophicBiofilms

Abstract Oxic microbial electrosynthesis using aerobic hydrogenotrophic bacteria requires productive cathodic biofilm formation, yet reactive oxygen species (ROS) generated at the electrode surface present a critical barrier to initial colonization. This study investigates biofil...

Termination under Optimal Play in the Two-Player 3n+/-1 Game

We address the two-player 3n+/-1 problem stated at https://althofer.de/collatz-prizes.html. The game is played on positive odd integers: a move replaces n > 1 by the odd part of either 3n-1 or 3n+1, and the player who reaches 1 wins. Arbitrary play need not terminate. We give a b...

Scientific Literacy Deficits, Vocabulary Barriers, and Evidence-Based Intervention Models in 21st-Century Science Education

Abstract Scientific literacy has become an indispensable competency for informed citizenship, evidence-based decision-making, and participation in a science- and technology-driven world. Yet persistent deficits in scientific literacy remain a critical global challenge, with PISA...

Gut Microbiome Dynamics in Chinese Mothers and Infants: A Longitudinal Cohort

This study provides a detailed map of how the gut microbiome changes individually in mothers during pregnancy and in their babies during the first critical months of life. By following a cohort of mother-infant pairs in China, we tracked the microbial community over time to under...

Oral anticoagulation therapy in nonagenarian patients with atrial fibrillation: usage patterns, predictors, and in-hospital outcomes from a single-center retrospective study

Abstract Background Atrial fibrillation (AF) is highly prevalent in nonagenarians (≥ 90 years). However, this group is often excluded from clinical trials, leaving limited real-world evidence on oral anticoagulant (OAC) use, safety, and efficacy. This study sought to investigate...

Hyperbaric oxygen therapy modulates immune aging in a personalized manner: a linear mixed-effects analysis

Abstract Background Immunosenescence, characterized by telomere shortening, senescence-associated T-cell subsets, and chronic inflammation, is a hallmark of biological aging. Whether these aging-related immune biomarkers can be modulated through short-term intervention and whethe...

Post-diagnostic support for dementia in the UK: mapping access, delivery and gaps in provision

Abstract Background Dementia is a progressive condition affecting approximately 982,000 people in the UK, with substantial implications for people living with dementia, carers, and healthcare systems. Effective post-diagnostic support is essential for managing symptoms and mainta...