Research works

Effect of apremilast on entheseal bone damage in psoriasis patients at risk of developing psoriatic arthritis - data from the prospective, interventional EPOS study

BACKGROUND/PURPOSE: A subset of psoriasis (PsO) patients exhibits subclinical entheseal inflammation and bone remodeling placing them at higher risk of developing psoriatic arthritis (PsA). Whether early pharmacological interventions during this phase can modulate these inflammat...

Corpus callosum fractional anisotropy from routine diffusion tensor imaging predicts dementia in older adults beyond clinical risk factors

Dementia arises from multifactorial neurodegenerative processes, with growing evidence implicating blood-brain barrier dysfunction, neuroinflammation, and vascular injury as contributors to progressive brain tissue damage. Because decline in white matter microstructural integrity...

A decision-tree for trend analyses following major survey redesigns: an analysis using the Canadian Community Health Survey (CCHS)

Abstract Background Monitoring health inequality trends is essential for assessing progress, stagnation, or regression on the reduction of health inequalities; assessing the impact of certain policies on health inequalities; and identifying emerging areas of concern. Because ineq...

Association between dynamic changes in the modified Glasgow prognostic score and disease progression in idiopathic pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with a highly variable clinical course. Identifying reliable and easily accessible biomarkers associated with disease progression remains a major clinical challenge. The mo...

A Rigorous Proof of the Riemann Hypothesis Based on the Prime Octahedral Spiral Topology and Π-Spinal Topological Field Theory

Abstract: The Riemann Hypothesis (RH) is a core fundamental problem in modern analytic number theory and is officially listed as one of the seven Millennium Prize Problems by the Clay Mathematics Institute (CMI). It essentially governs the intrinsic correlation between the non-tr...

When Does Member Governance Substitute for Regulation in Consumer-Owned Utilities?

Abstract This paper asks when member governance can substitute for external regulation in consumer-owned natural monopolies. Holding quantities fixed, usage-proportional patronage refunds neutralize the transfer motive for monopoly over-pricing, shifting the welfare margin toward...

Mixed electoral systems: The best of both worlds or the worst of both?

Abstract Mixed electoral systems combine majoritarian and proportional rules within a single institutional framework, promising what Shugart and Wattenberg (2001) called "the best of both worlds": local accountability alongside representational fairness. This article surveys the...

A Machine Learning Framework for Identifying and Detecting Potentially Habitable Exomoons Around Sub-Neptunian Planets

This study presents a conceptual two-stage machine learning framework for identifying and detecting potentially habitable exomoons around sub-Neptunian planets. The framework addresses the difficulty of detecting weak, indirect, and phase-varying exomoon signatures by combining p...

Optimizing cold storage of Sitotroga cerealella eggs for the mass rearing of Trichogrammatoidea bactrae: Effects on reproductive performance of parent and progeny

Abstract Improving effective cold storage techniques for maintaining factitious host eggs without adversely affecting their quality and the performance of emerged parasitoids is essential. Therefore, this study investigated the effects of different storage temperatures (–2 °C, 2...

Execution Coverage Reconciliation: measuring the ungoverned surface when absence of bypass cannot be proved from inside

A governance gate that commits a hash-chained receipt in the same transaction as its determination binds determination to evidence, but binds nothing to effect: the transition occurring in the world is a separate event on a separate system the governing runtime cannot observe. Ab...

Development of (polyvinyl alcohol/O-carboxymethyl chitosan/PbO) nanocomposites for efficient gamma radiation protection

Abstract A polymeric blend based on polyvinyl alcohol (PVA) / carboxymethyl chitosan was developed for gamma radiation shielding applications. The nanocomposite films were fabricated using a simple solution casting method, where the readily available nanosized lead oxide PbO part...

Real-Time Fraud Detection in Mobile Payments: Behavioral Biometrics and Transaction Anomaly Fusion

Research article: Real-Time Fraud Detection in Mobile Payments: Behavioral Biometrics and Transaction Anomaly Fusion

What the Test Suite Could Not See: An Error Taxonomy from Building a Neuro-Symbolic Food-Label Compliance System for Arabic Labels

AbstractFood-label compliance verification is a high-stakes regulatory task, and the neuro-symbolic pattern — a probabilistic perception layer feeding a deterministic judgment layer — is an established response to it. This paper does not propose that architecture. It reports what...

Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site

Abstract The SM-protein Munc18 and its binding partner syntaxin are crucial for two distinct steps of regulated exocytosis, docking of secretory granules at the release site, and priming reactions that prepare docked granules for Ca 2+ dependent fusion. Both proteins cluster simu...

PUH Theorem 320 (The Missing Coupling Term) — Symmetry Forces the Nearest-Neighbour Energy; the E8 Lattice Is Isotropic to SIXTH Order Because It Has No Degree-4 or Degree-6 Casimir; and Directional Lorentz Violation Falls to (a/λ)⁶

Photonic Universe Hypothesis (PUH) — Postulate and Consequences. THE GAP IS SINGULAR, NOT PLURAL. T298's audit recorded that T175's Lagrangian contains NO SPATIAL DERIVATIVES — no gradient term, no dependence on x — and is constrained optimization at a point in the 248-dimensiona...

Traumatic brain injury in African urban centers: The role of road traffic accidents, outcomes, and health-system factors: a systematic review

Abstract Background Traumatic brain injury (TBI) is a major cause of death and disability in low- and middle-income countries, particularly in rapidly urbanizing regions of Sub-Saharan Africa. Road traffic accidents (RTAs), especially motorcycle-related crashes, represent a leadi...

Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults

Abstract Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood. Identifying frailty in this popula...

Moral emotion processing in euthymic bipolar disorder: insights from network analysis

Abstract Background Bipolar disorder (BD) is associated with facial emotion recognition (FER) deficits. Among these, impairments in recognizing moral emotions may be especially relevant to social dysfunction, but their relationship with brain structure remains poorly defined. Met...

Resveratrol attenuates tubular injury in diabetic kidney disease by suppressing the ferroptosis–ferritinophagy pathway

Abstract Background Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, and renal oxidative stress (OS)–mediated tubular injury plays a critical role in its progression. Resveratrol (Res) possesses established antioxidative properties, yet its mechanistic...

Evaluating large language model performance in US FDA regulatory science

Abstract Background Clinical and population decision-making relies on the systematic evaluation of extensive regulatory evidence. The FDA drug reviews provide detailed information on clinical trial design, enrollment criteria, sample size, randomization, comparators, endpoints, a...