Research works

Multicentre biobanking for rare diseases in India: Utility and challenges of lymphoblastoid cell line generation

Background and objectives For rare disease research, we aimed to establish immortalised lymphoblastoid cell lines (LCLs) from patient-derived blood samples. LCLs serve as a reliable substitute for accessing and studying the patient-specific disease biology, as patients may not al...

Breathing Easy Together: How Positive Airway Pressure Adherence Benefits Both Patients and Partners

Objectives: Emerging research highlights the interdependence of sleep within couples and the impact of sleep disorders on couples’ relationship quality; however, most sleep treatments are focused solely on the individual. WePAP is a dyadic, behavioral treatment to promote positiv...

Low-cost single-beam SONAR localization in AUVs: Systematic experiments with acoustic and optical perception

This work presents a low-cost acoustic sensing framework for underwater robot (UWR) localization and perception, using single-beam sonars (SBS) and an external forward-looking sonar (FLS) for confined environments in place of costlier Doppler velocity logs (DVL) and onboard imagi...

Deep learning–based prediction of one-year functional and structural outcomes in treatment-naïve DMO after anti-VEGF therapy

Abstract Purpose To evaluate whether baseline structural optical coherence tomography (OCT) scans contain prognostic information that can be used by deep learning models to predict one-year functional and anatomical outcomes in treatment-naïve diabetic macular oedema (DMO). Desig...

Integrated retrieval of ocean surface wind and current fields from single-geometry SAR observations through a physically constrained Bayesian framework

Ocean surface winds and currents are coupled through air–sea interaction but are commonly retrieved independently from spaceborne synthetic aperture radar (SAR). For operational single-geometry SAR, simultaneous wind–current retrieval is underdetermined and remains reliant on bac...

South Asia's cardiometabolic burden: exposomal determinants of a health transition

South Asia is facing an escalating burden of obesity, type 2 diabetes (T2D), dyslipidemia, metabolic dysfunction–associated steatotic liver disease (MASLD), and premature atherosclerotic cardiovascular disease.1–4 In 2023, high systolic blood pressure (SBP) accounted for nearly 1...

Chitosan film based piezoelectric nanogenerator for ambient energy harvesting

Herein, we report a flexible chitosan-based piezoelectric nanogenerator (CPENG) fabricated using a simple and scalable solution-casting method from commercially available chitosan, an abundant and environmentally friendly biopolymer. The CPENG efficiently converts low-frequency m...

Pre-ECMO characteristics, organ dysfunction and exploratory mortality prediction in COVID-19 versus non-COVID-19 ARDS treated with veno-venous ECMO: a retrospective cohort study

Abstract Objective The transferability of pre-ECMO characteristics and established mortality prediction tools across COVID-19 (C-19) and non-COVID-19 (nC-19) acute respiratory distress syndrome (ARDS) remains uncertain. We compared clinical characteristics, organ dysfunction, res...

Redox-Active Microneedle Platforms for ROS Modulation in Chronic Wound Healing

Chronic wounds represent a growing clinical and economic burden, and their impaired healing is closely linked to a disrupted redox environment. Reactive oxygen species (ROS) are essential signaling molecules that regulate each phase of wound healing, from hemostasis and inflammat...

Perceptions of Socio-Technological Shifts and Ethical Risks among Next-Generation Emirati IT Specialists: An Empirical Assessment

The accelerating evolution of digital infrastructures and cognitive technologies has fundamentally reshaped contemporary social fabrics; a complex matrix of systemic opportunities and ethical challenges. However, while the socio-economic dividends of automation abound, the swift...

RF-DETR with multi-scale feature fusion and explainable attention for accurate brain tumor detection in MRI

Abstract Magnetic Resonance Imaging (MRI) is very crucial in the diagnosis and examination of brain tumors because it can give good images of the soft tissues and anatomy. Nonetheless, the detection and localization of the tumor areas are still difficult due to differences in tum...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Neonatal and Maternal Sepsis in Gulf Cooperation Council Countries, 1990–2023: A Global Burden of Disease Analysis and Forecast to 2050

Introduction: Sepsis remains an important cause of preventable morbidity and mortality, but long-term trends in neonatal and maternal sepsis across the Gulf Cooperation Council (GCC) have not been well characterized. Methods: We analysed Global Burden of Disease (GBD) 2023 estima...

OsDRP1C mediates root development by modulating OsPIN1 cycling in rice

Summary Root length plays a crucial role in plants' ability to absorb water and nutrients from the soil. However, the molecular mechanisms underlying root elongation in rice ( Oryza sativa ) remain unclear. Here, we identified a short root mutant, short root‐31 ( sr31 ), and clon...

Harnessing hydrogel technology for advanced periodontitis therapy: A multifunctional approach to oral health restoration

Periodontitis is a bacterially driven inflammatory disease that can lead to tooth mobility and tooth loss. Conventional non-surgical therapy, antibiotics, and surgery may be limited by residual subgingival biofilms, antimicrobial resistance, and variable clinical outcomes. This r...

Flexural dispersion curves of acoustoelastic borehole waves by the perturbation method in a triaxially stressed transversely isotropic formation with vertical symmetry

Abstract Cross-dipole acoustic logging is widely used to determine the maximum horizontal stress azimuth and stress imbalance in vertical boreholes within isotropic formations. However, theoretical analysis of dipole flexural dispersion under imbalanced stresses in transversely i...

Emerging Nanofiber Production Technologies: Principles, Advances, and Applications

Nanofibers have attracted increasing attention across multiple industries, including pharmaceuticals, biomedicine, textiles, environmental purification, and food packaging, owing to their exceptional physicochemical properties. Composed of polymers engineered for specific functio...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Cortical and metabolic brain development during pubertal hormone suppression

Suppression of pubertal hormonal signaling may alter trajectories of cortical development. However, the neurobiological effects of gonadotropin-releasing hormone agonists (GnRHa), including triptorelin, which are used in adolescents with gender dysphoria, remain largely unresolve...

Organ-Specific Phenolic Specialization and Antioxidant Responses in Crocus cancellatus: LC–MS/MS and Multivariate Analysis

Organ-specific allocation of phenolic metabolites may shape antioxidant responses in Crocus species. This study characterized stamen, pistil, tepal, perigon tube, and corm of Crocus cancellatus Herb. using ultrasound-assisted methanolic extraction, liquid chromatography–tandem ma...