Key considerations for window of opportunity trials and preoperative endocrine therapy in breast cancer
Abstract
Window of opportunity (WOO) trials are short, pre-surgical trials which aim to evaluate novel therapeutic strategies and answer biological and mechanistic questions. Despite their relative simplicity, their conduct can be challenging. This Perspectives Article considers key factors relevant for the optimal design and interpretation of WOO trials in the context of oestrogen receptor positive breast cancer, and provides insights for clinicians using preoperative endocrine therapy in a non-trial setting.
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Authors: Lucy Roxana Haggstrom, Rebecca Burrell, Andrew Parker, Kate Middleton, Sarah Childs, Alan Stuart Coates, Elgene Lim, Richard D. Baird
Institutions: The University of Sydney, UNSW Sydney, Cancer Research UK, Cambridge University Hospitals NHS Foundation Trust, Garvan Institute of Medical Research, St Vincent's Hospital Sydney, Cancer Research UK Cambridge Center