Cancer Research UK Cambridge Center

Nature‐Inspired Histidine and Guanidine Modification of Magnetic Nanoparticles for Urinary DNA Liquid Biopsy

ABSTRACT Urinary cell‐free DNA (cfDNA) is a promising substrate for non‐invasive liquid biopsy analysis and biomarker detection. However, the lack of standardized pre‐analytical workflows and the intrinsic challenges associated with isolating highly dilute and fragmented cfDNA li...

From established biology to candidate archetypes in high-grade serous ovarian carcinoma: the ARCHETYPE-PX evidence framework and consensus method

Background. High-grade serous ovarian carcinoma (HGSOC) causes most deaths from ovarian cancer, and treatment remains largely empirical outside the homologous-recombination-deficient subgroup. Genomic, immune, stromal and treatment-induced states with different therapeutic vulner...

Randomised phase III trials of cancer prevention drugs: a systematic review and prediction of trial success

BACKGROUND: Pharmacological cancer risk reduction has received far less investment than therapeutic oncology and only a few agents have entered routine practice. Understanding the predictors of positive outcomes of previous trials and issues faced is critical to future developmen...

Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis

Abstract Interactions between epithelial cells and fibroblasts influence disease progression and treatment response in pancreatic ductal adenocarcinoma (PDAC). While the diversity of fibroblasts in PDAC is increasingly recognized, it remains unclear how these cells differ from fi...