Cancer Research UK

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

The mirrored burden and accountable handovers in cancer survivorship: co‑designing a post‑treatment transition standard

Post-treatment transitions after active cancer care often lack clear ownership, timelines and closure rules, shifting coordination work onto survivors and staff. We aimed to identify how these failures arise and to co-design a handover standard for post-treatment survivorship car...

Comparison of NICE criteria with the BOADICEA multifactorial risk model to guide breast cancer risk assessment and referral amongst women under age 50 within primary care

BACKGROUND: The National Institute for Health and Care Excellence (NICE) recommends that women at above-population-level risk of breast cancer (BC) are offered enhanced screening and risk-reducing interventions. Identification of these women largely relies on referral through pri...

Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring

Abstract Liquid biopsy has emerged as a transformative development in oncology, enabling the minimally invasive detection and monitoring of cancer through the analysis of tumor-derived material in blood. Moving beyond single-variable analysis, multifeature sequencing-based liquid...