Cancer Research UK

Collaboration in action: Protocol development across the MRC National Mouse Genetics Network

Collaboration and multidisciplinary approaches are key factors in the advancement of scientific research. This Backstory introduces the guiding philosophy and the collaborative nature of the MRC National Mouse Genetics Network (NMGN) and serves to set the foundation for the conte...

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

ABSTRACT High‐risk estrogen receptor positive (ER+) early breast cancer (EBC) is managed with endocrine therapies and cyclin‐dependent kinase (CDK) 4/6 inhibitors, although no standard molecular markers clinically identify these tumors. CDK1 lies immediately downstream of CDK4/6...

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using com...

Key considerations for window of opportunity trials and preoperative endocrine therapy in breast cancer

Window of opportunity (WOO) trials are short, pre-surgical trials which aim to evaluate novel therapeutic strategies and answer biological and mechanistic questions. Despite their relative simplicity, their conduct can be challenging. This Perspectives Article considers key facto...

Postoperative outcomes and costs associated with multimodal prehabilitation for advanced ovarian cancer surgery: an exploratory retrospective cohort study at a UK specialist centre

Neoadjuvant chemotherapy (NACT) followed by cytoreductive surgery (CRS) is the standard of care for advanced ovarian cancer and is associated with deconditioning and a high burden of perioperative morbidity. Multimodal prehabilitation may attenuate physiological decline during NA...

Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics

Abstract The meninges are increasingly recognized as key stromal and immune niches supporting cranial development. Here we constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks...

Receptor tyrosine kinase targeted therapies in glioblastoma: a systematic review

Introduction Glioblastoma is the most common primary central nervous system malignancy and has a median survival of 14.6 months. Receptor tyrosine kinase (RTKs) signalling consitutes one of the three major pathways driving glioblastoma, implicating them as a therapeutic target. H...

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis

Clonal haematopoiesis (CH) is driven by somatic mutations in haematopoietic stem cells that generate clonal populations detectable in peripheral blood and is present in 10-20% of individuals over the age of 65. Mutations in DNMT3A and TET2 are the most common drivers and have bee...

Lower Urinary Tract Dysfunction in Renal Transplant Candidates: A Scoping Review of Assessment Methods and Post‐Transplant Urological Outcomes

PURPOSE: We performed a scoping review to map the available evidence regarding pre-transplant lower urinary tract dysfunction (LUTD) assessment in adult renal transplant candidates and to summarise reported associations between pre-transplant LUTD and post-transplant urological o...

Validating the biological origin of in vivo fractional intracellular volume from VERDICT-MRI in the prostate

Abstract Objective Noninvasive microstructure estimates using magnetic resonance imaging (MRI) show potential in improving prostate cancer (PCa) diagnosis; however, histological validation is necessary. Materials and methods We used data from the Histo-MRI trial (NCT04792138). Pa...

Advances in Organoid Technology: Bridging the Gap Between Research and Therapy

Organoids Are Us is a symposium series that provides a snapshot in time of the latest and emerging developments in organoid technology [...]

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

The mirrored burden and accountable handovers in cancer survivorship: co‑designing a post‑treatment transition standard

Post-treatment transitions after active cancer care often lack clear ownership, timelines and closure rules, shifting coordination work onto survivors and staff. We aimed to identify how these failures arise and to co-design a handover standard for post-treatment survivorship car...

Comparison of NICE criteria with the BOADICEA multifactorial risk model to guide breast cancer risk assessment and referral amongst women under age 50 within primary care

BACKGROUND: The National Institute for Health and Care Excellence (NICE) recommends that women at above-population-level risk of breast cancer (BC) are offered enhanced screening and risk-reducing interventions. Identification of these women largely relies on referral through pri...

Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring

Abstract Liquid biopsy has emerged as a transformative development in oncology, enabling the minimally invasive detection and monitoring of cancer through the analysis of tumor-derived material in blood. Moving beyond single-variable analysis, multifeature sequencing-based liquid...