Engineering hematopoietic stem and progenitor cells to generate red blood cells as viral traps against HIV-1.
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Abstract
. In sum, this work presents a potential strategy for the one-time delivery of CD4-RBC viral traps through autologous transplantation of engineered HSPCs.
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Authors: Sofia E. Luna, William N. Feist, Kaya Ben-Efraim, Alex Pendergast, Freja K. Ekman, Britney Hernandez-Naughton, Megan Merritt-Garza, Kathleen Romero, Zak Kostamo, Nelson A. Amorin, Nicole M. Johnston, Hana Y. Ghanim, Vivien Sheehan, Amanda M Dudek, Matthew H. Porteus
Institutions: Children's Healthcare of Atlanta, Emory University, University of Iowa, Stanford University, Center for Cancer and Blood Disorders