Center for Cancer and Blood Disorders

A global study of novel agents in paediatric and adolescent relapsed and refractory B-cell non-Hodgkin lymphoma (Glo-BNHL): protocol for an adaptive international platform clinical trial

The second Paediatric Strategy Forum of the international multi-stakeholder organisation, ACCELERATE (Nov-2017), concluded that an international approach to conducting clinical trials in relapsed and refractory paediatric B-cell non-Hodgkin lymphoma (r/r B-NHL) was critical and t...

When, Where, and How Much: Toward Smarter Design and Delivery of CAR T-Cell Therapy

Abstract Chimeric antigen receptor (CAR) T-cell therapies have fundamentally reshaped clinical oncology by achieving durable remissions in refractory hematologic malignancies. However, their broader translation remains bottlenecked by severe, treatment-associated hyperinflammator...

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

ABSTRACT Sepsis‐induced pediatric acute lung injury (ALI) and pediatric acute respiratory distress syndrome (PARDS) are life‐threatening conditions with high mortality rates and no current cure. Most ALI/ARDS studies focus on adults, albeit the pediatric population has unique cha...

Impact of post‐chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children’s Oncology Group AREN0532, AREN0533, and AREN03B2 studies

Abstract Background Improvements in therapy for patients with favorable histology Wilms tumor (FHWT) have relied on refinement of risk stratification for therapeutic assignment through identification of favorable and unfavorable prognostic factors. Although well established in In...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

Engineering hematopoietic stem and progenitor cells to generate red blood cells as viral traps against HIV-1.

. In sum, this work presents a potential strategy for the one-time delivery of CD4-RBC viral traps through autologous transplantation of engineered HSPCs.

Feasibility of Real‐Time Central Risk Assignment for Children's Oncology Group Pediatric Renal Tumor Trials

BACKGROUND: The Children's Oncology Group (COG) AREN03B2 Renal Tumor Biology and Classification Study undertook real-time central reviews to enable accurate risk stratification for enrollment on therapeutic trials. The present study assessed the feasibility of the central review...

Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials

The extracellular matrix (ECM) of glioblastoma (GBM) is known to modulate cell behavior, yet the specific contributions of matrix biochemical and biomechanical signaling remain poorly understood. To address this, we engineer a tunable hyaluronan-elastin-like protein (HELP) hydrog...