University of Iowa

The Use and Utility of Preoperative Somatostatin Receptor-Based Imaging in Gastroenteropancreatic Neuroendocrine Tumors

Abstract Background Contemporary gastroenteropancreatic neuroendocrine tumor (GEPNET) management guidelines recommend routine use of functional imaging preoperatively, but there are few data highlighting trends in functional imaging adoption. This report reviews 24 years of neuro...

Electoral reforms rejected: Partisan cues in an anti-party context

Proposals to change how parties functioned in elections appeared on several American states’ ballots in 2024, often bundling nonpartisan primaries (NPPs) with ranked choice voting (RCV). Given the complexity of the proposals, voters faced a difficult task and may have relied on c...

Demslide or republican resilience? A political history forecast of the 2026 us congressional elections

The history book on the shelf is always repeating itself," an oft-cited line from ABBA's song Waterloo, captures the intuition that politics often shows persistence and is governed by identifiable patterns or "laws."Building on this, we take a structural approach to election pred...

Political Economy Forecasts: The 2026 Midterms

We employ a political economy model to forecast the outcome of the 2026 midterm elections in the House and Senate.Earlier versions of our model have been utilized, to good effect, since 2010.The model draws on sound theory, which posits the importance of political and economic fu...

Forecasting 2026 Congressional Control: A Comparison of IEM and Kalshi Prediction Markets

We report Iowa Electronic Markets (IEM) and Kalshi prediction market forecasts for the congressional control configuration resulting from the 2026 U.S. midterm elections.Both exchanges run separate markets on House and Senate control.Both indicate the most likely outcome is Democ...

HIV-1 hijacks HGF/c-MET signaling to promote viral entry and replication in primary CD4 + T cells

ABSTRACT The mesenchymal-epithelial transition factor (c-MET) is a receptor tyrosine kinase best known for mediating hepatocyte growth factor (HGF) signaling in cancer, but its role in HIV-1 infection has remained unclear. Here, we identify c-MET as a host factor that promotes HI...

Ploidy is associated with multielemental reorganization across soft and mineralized body compartments

Polyploidy alters nuclear DNA content, gene dosage and cellular organization, but its consequences for organismal chemistry remain poorly resolved, particularly in animals. Because nucleic acids and associated cellular machinery require coordinated allocation of multiple elements...

Ice-ray pentagonal packing of pseudo-fivefold helices

While fivefold point symmetry is common in nature, fivefold spatial symmetry is seldom observed. Regular pentagons cannot tile a plane without leaving voids, and even the densest “ice-ray” packing is exceptionally rare. Fivefold helices are equally elusive. We report a small mole...

PGP-5 Influences ZIP-2-Dependent Innate Immune Response During Streptococcus gordonii Exposure in Caenorhabditis elegans

Innate immune responses in Caenorhabditis elegans are regulated by multiple effectors that are activated upon bacterial exposure. In this study, we investigated the role of pgp-5, a transmembrane efflux transporter implicated in cellular stress responses and detoxification in hos...

Hemagglutinin and fusion proteins precede measles virus ribonucleoproteins and marshal cell-to-cell spread in airway epithelium

ABSTRACT Measles virus (MeV) is the most contagious human respiratory pathogen. To understand how it spreads in the airways, we infected well-differentiated primary cultures of human airway epithelial cells (HAE). We discovered that the MeV attachment protein (hemagglutinin, H),...

Rethinking Gifted Child Counseling: A Critique and a Proposal

Most researchers and practitioners have treated the findings from studies addressing gifted children’s presumably unique social and emotional needs as reasonable, verifiable, and theoretically sound. This review took a more skeptical approach. Following Ricoeur’s (1970) “hermeneu...

Endoscopic Retrograde Cholangiopancreatography in Pediatric Pancreas Divisum: Systematic Review

Background: Pancreas divisum (PD) may be associated with recurrent acute pancreatitis (RAP) or chronic pancreatitis (CP), but data on ERCP outcomes in children with PD are limited. We conducted a systematic review of the clinical, technical, and safety outcomes of ERCP for PD in...

From academic identity to academic branding: organisational culture and cultural homogenisation in the newer normal of global higher education

In the post‑pandemic ‘newer normal’, higher education has consolidated market‑oriented, audit‑driven organisational cultures rather than returning to pre‑2020 norms. This paper argues that academic branding now operates as a governing cultural regime reshaping academic labour and...

Left Ventricular Structural, Physiological, and Transcriptomic Abnormalities in a Novel Porcine Hypertrophic Cardiomyopathy Model

sensitivity. The cardiac myosin inhibitor MYK-581 reduced hypercontractility and improved diastolic function. Data from this large animal genetic model of HCM strengthen the mechanistic link between genetic variants and in vivo phenotypes and elucidate the mechanisms of myofilame...

Using machine learning and preoperative data to predict 30-day mortality after non-cardiac major surgeries in older patients

Postoperative mortality remains a critical concern, especially among older patients undergoing non-cardiac major surgeries. With over 300 million surgeries performed worldwide annually, a significant proportion involves elderly patients, making early and precise risk stratificati...

Hospital wastewater-based antimicrobial resistance epidemiology: a scoping review

Abstract Introduction: Wastewater-based epidemiology (WBE) offers pooled biological samples of defined populations, complementing clinical surveillance for infectious diseases. Hospitals are hotspots for antimicrobial resistance (AMR). We performed a scoping review assessing hosp...

Calibration and Design Considerations for Multidimensional Multistage Testing

Abstract Multidimensional multistage testing (MMST) combines multidimensional item response theory (MIRT) with adaptive multistage testing design to measure multiple related constructs efficiently. Despite its potential for large‐scale assessments, little research has examined ca...

The effect of resting tongue pressure, lip-cheek pressure, and interdental force on mandibular arch collapse and mesial molar drift: A preliminary 3D finite element study

Relapse of aligned mandibular anterior teeth and the progressive collapse of the mandibular anterior arch are historically significant problems for orthodontists. The etiology of this collapse, and the cause of mesial molar drift, are unknown. However, light continuous (quasi-con...

ProMUSE: Progressive Multi-modal Uncertainty-guided Staged Evidential Alzheimer Disease Classification

Alzheimer's disease (AD) is a fatal disorder that destroys memory and cognitive skills in the elderly population. Most treatments for AD are effective in the early stage, leading to an increasing demand for early AD diagnosis. AD diagnosis increasingly relies on multimodal data s...

Maternal Sedentary Behavior and Breast Milk Extracellular Vesicle MicroRNA Across Pregnancy: A Pilot Study

Background/Objectives: Human breast milk (HM) is the gold-standard nutritional source for infants, delivering not only macro- and micronutrients but also bioactive components, including extracellular vesicles (EVs) enriched with microRNAs (miRNAs) that regulate immune, metabolic,...