Discordant ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT Findings Before Radionuclide Therapy in Small Cell Lung Cancer
Abstract
A 54-year-old man with progressive small cell lung cancer underwent ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT before radionuclide therapy. ¹⁸F-FDG PET/CT evaluated disease extent and identified metabolically active lesions. ⁶⁸Ga-DOTATATE PET/CT showed high SSTR expression in bone lesions and the pancreatic tail. Discordant hepatic uptake suggested tumor heterogeneity. The two scans provided complementary information on disease activity and therapeutic target expression, supporting patient selection and individualized planning for an SSTR-targeted radionuclide therapy–based comprehensive treatment strategy.
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Authors: Shijie Tang, 雷庆林, Ya Liu, Yanggang Liu, Lin Qiu
Institutions: Target (United States), Affiliated Hospital of Southwest Medical University, Theranostics (New Zealand), Southwest Medical University, Molecular Theranostics (United States)