Theranostics (New Zealand)

Synthesis and Preliminary Biological Evaluation of a Structurally Modified Niraparib-Based PARP-Targeted PET Tracer for Tumor Imaging

Abstract Poly(ADP-ribose) polymerase (PARP) is highly expressed in various malignancies and represents an important therapeutic target. Noninvasive evaluation of PARP expression is therefore of potential clinical significance for patient stratification. In this study, we develope...

Synthesis, Preclinical Evaluation, and Clinical Application of the FAPI‐Dimer Based on the LARM Platform

ABSTRACT Fibroblast activation protein (FAP) is a promising pan‐tumor target for theranostics, but current FAP‐targeted radioligands are limited by insufficient tumor retention and suboptimal therapeutic doses. To address these challenges, we developed a novel LARM platform and s...

Water‐driven dispersible fiber electrode arrays for position‐dependent intracardiac electrophysiological recording

Abstract Intracardiac electrophysiological recording plays an essential role in identifying abnormal cardiac electrical activity and guiding arrhythmia diagnosis and treatment planning. A key challenge for minimally invasive intracardiac electrodes is to combine reliable transvas...

Anion–π Interaction‐Regulated Ion Generation and High Piezoionic Response in Ultrasoft Low‐Salinity Hydrogels

ABSTRACT Anion–π interactions play important roles in underwater cohesion and selective ion recognition and transport in biological systems. Inspired by these functions, we report the first hydrogel system employing anion–π interactions as a design motif for piezoionic energy con...

Discordant ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT Findings Before Radionuclide Therapy in Small Cell Lung Cancer

A 54-year-old man with progressive small cell lung cancer underwent ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT before radionuclide therapy. ¹⁸F-FDG PET/CT evaluated disease extent and identified metabolically active lesions. ⁶⁸Ga-DOTATATE PET/CT showed high SSTR expression in bone lesions...

The ATC score: a novel efficacy scoring model for risk stratification and personalized management of unresectable HCC patients receiving TACE-lenvatinib-PD-1 inhibitor therapy

Unresectable Hepatocellular Carcinoma (uHCC) has limited therapeutic options. The combination therapy of Transarterial chemoembolization (TACE), lenvatinib, and PD-1 inhibitors (T-L-P) shows promising efficacy, but a tool to predict individual treatment responses is lacking. To d...

Stromal Cells Recruitment by Sono‐Piezoelectric/Pyroelectric Peptide Hydrogels Promotes Bone Regeneration After Postsurgical Osteosarcoma Recession: A Real‐World‐Matched Study

ABSTRACT Currently, the elimination of postsurgical osteosarcoma (OS) and defect repair are still separately explored, which is unlike real‐world clinical scenarios. Inadequate bone marrow stromal cells (BMSCs) compromise their repair and antitumor efficiencies. Here, PFSSTKT (PF...