Southwest Medical University

Association between timely and standardized nursing pain management and outcomes in terminal cancer patients

Effective pain management is essential for terminal cancer patients in emergency settings, yet nursing protocol adherence remains suboptimal. This study aimed to evaluate the association between key nursing process indicators and pain relief outcomes in terminal cancer patients p...

Modified cardiopulmonary bypass in low-weight adults: a randomized controlled trial of inflammatory factor changes and the potential for transfusion savings

Cardiopulmonary bypass (CPB) is an essential technique in cardiac surgery; however, conventional CPB systems may induce hemodilution and inflammatory responses, particularly in patients with low body weight. This study aimed to evaluate the effects of a modified CPB system on per...

Association of uric acid-to-albumin ratio with diabetic kidney disease

This study investigates the association between a novel inflammatory marker, the uric acid-to-albumin ratio (UAR), and diabetic kidney disease (DKD). We used multivariable logistic regression models to evaluate the independent associations of UAR with DKD, albuminuria, and reduce...

A retrospective cohort study of the association between triglyceride-glucose index and its derived indicators and all-cause mortality among community-dwelling adults with a history of stroke

Abstract Objective As a novel marker of insulin resistance, the triglyceride-glucose (TyG) index has been documented to correlate with mortality in coronary artery disease and heart failure. In recent years, growing attention has been paid to the relationship between the TyG inde...

Preparation of Uniform Nonspherical PLGA Particles in the Nanosize Range by Using a Two-Step Premix Membrane Emulsification Technique

Abstract The shape of polymeric particulate systems is a critical determinant of their in vivo fate, and nonspherical nanoparticles are promising candidates for advanced drug delivery. However, spherical-shaped particles are usually produced by conventional emulsion-based methods...

Photoredox‐Catalyzed 1,2,2‐Trifunctionalization of Alkenes with 1,7‐Enynes and α‐Bromocarbonyls

Comprehensive Summary Cyclopenta[ c ]quinoline derivatives represent privileged structural motifs that exhibit remarkable potential biological activities, which have prompted considerable interest in developing green, efficient and general synthetic strategies for constructing th...

Preoperative ECG-based machine learning model for early prediction and risk stratification of postoperative delirium

Postoperative delirium (POD) is a serious neuropsychiatric complication that commonly occurs within days after surgery. Early identification of high-risk individuals is crucial for implementing effective preventive and management strategies. This paper developed a machine learnin...

Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV

Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric s...

Beyond clinical grading: rethinking arthrogenic muscle inhibition after anterior cruciate ligament reconstruction

Abstract Arthrogenic muscle inhibition (AMI) remains a clinically important barrier to recovery after anterior cruciate ligament reconstruction. In their recent retrospective study, Morel et al. identified early preoperative and postoperative correlates of AMI using the clinical...

Comparative evaluation of dental pulp and periodontal ligament stem cell sheets for rescuing periodontal-like tissue formation in cryopreserved tooth autotransplantation

Autologous tooth transplantation (ATT) is a biologically based approach for the management of tooth loss, particularly among adolescents. However, its broader application is limited by challenges associated with tooth cryopreservation and stem cell-based strategies, and current s...

The Immunomodulatory Effects of Mannan on the Fungicidal Activity of Macrophages Against Candidozyma auris Bloodstream Infection Associated with the GPCR-PI3K-NF-κB Signaling Pathway

Candidozyma auris is an emerging multidrug-resistant fungal pathogen, which causes high mortality and nosocomial outbreaks worldwide. Macrophages are key innate immune cells that clear fungi through phagocytosis, reactive oxygen species, and cytokine secretion. Mannan, a major fu...

Safety and satisfaction of voluntary medical male circumcision among men who have sex with men in China

PURPOSE: To investigate the safety and satisfaction of circumcision among men who have sex with men (MSM), as voluntary male medical circumcision (VMMC) may be an innovative and acceptable tool for HIV prevention among this population in the future. METHODS: Participants who volu...

Antineoplastic agent-induced palmar-plantar erythrodysaesthesia syndrome: insights from the FDA adverse event reporting system

Palmar-plantar erythrodysaesthesia syndrome (PPE), also called hand-foot syndrome (HFS), is a common cutaneous adverse reaction to anticancer drugs that impairs patients’ quality of life. This study analyzed PPE reports from the U.S. FDA Adverse Event Reporting System (FAERS) to...

Association of sarcopenia with bone metabolism markers and development of an internally validated screening model for sarcopenia in maintenance hemodialysis patients

Sarcopenia is a prevalent complication in maintenance hemodialysis (MHD) patients and is associated with adverse outcomes. This study aimed to investigate the relationship between sarcopenia and bone metabolism markers and to develop a clinical screening model for sarcopenia in M...

Discordant ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT Findings Before Radionuclide Therapy in Small Cell Lung Cancer

A 54-year-old man with progressive small cell lung cancer underwent ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT before radionuclide therapy. ¹⁸F-FDG PET/CT evaluated disease extent and identified metabolically active lesions. ⁶⁸Ga-DOTATATE PET/CT showed high SSTR expression in bone lesions...

68Ga-FAPI-04 PET/CT has high diagnostic efficacy in Tg-positive and Tg-negative differentiated thyroid cancer

Background Thyroglobulin (Tg) is a standard biomarker for monitoring differentiated thyroid carcinoma (DTC) after radioiodine therapy, yet its reliability is compromised by false-positive and false-negative results. This study aimed to evaluate the diagnostic performance of 68 Ga...

Sodium-glucose cotransporter-2 inhibitors and gastrointestinal neoplasm risk in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Abstract Background The potential carcinogenic effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) remain controversial, particularly regarding site-specific gastrointestinal (GI) neoplasms. This systematic review and meta...

Motivation, engagement, and perceived competence gains in competition-based medical education: a theory-informed structural equation modeling study

Competition-based learning is increasingly used in medical education to promote active participation, innovation, and collaborative problem solving. However, less is known about how students’ participation motivation, engagement, perceived competence gains, and satisfaction are r...

Current Situation and Influencing Factors of Parents' Knowledge，Attitudes，and Practice of Childhood Sexuality Education in Xichang City.

<0.001） had higher overall good rates of knowledge，attitudes，and behavior in childhood sexuality education. Conclusions Parents generally have low rates of knowledge awareness，positive attitudes，and good practice and a low overall good rate of knowledge，attitudes，and pract...

A Cross-Sectional Study of Short-Video Viewing and Young Adult Health: Dose–Response Relationships with Sleep, Dream Anxiety, Ocular Surface, and Quality of Life

Background: Short-video platforms (e.g., Douyin, TikTok) have gained immense popularity among young adults, yet their addictive potential and health consequences remain understudied. Unlike gaming addiction, which has been linked to myopia and mental distress, short-video viewing...