Affiliated Hospital of Southwest Medical University

Comparison of three interpretation criteria for [⁶⁸Ga]Ga-DOTATATE PET/CT in suspected pheochromocytoma and paraganglioma of the adrenal gland or retroperitoneal space

Pheochromocytomas and paragangliomas (PPGLs) frequently overexpress somatostatin receptor subtype 2 (SSTR2), making [ 68 Ga]Ga-DOTATATE PET/CT a promising functional imaging modality. However, the optimal interpretation criteria for distinguishing PPGL from non-PPGL lesions in cl...

ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1

Hepatocellular carcinoma (HCC) is characterized by profound metabolic reprogramming that promotes tumor progression. Although zinc finger MIZ-type containing 1 (ZMIZ1) has been implicated in several malignancies, its biological function and underlying mechanism in HCC remain uncl...

Pre-service sex education training and teaching practices among special education teachers: a cross-sectional survey

This study aimed to determine the current status of school-based sex education for children with disabilities (SECD) in Sichuan Province and to examine the association between pre-service sex education learning experience and SECD practice. A stratified random cluster sampling wa...

A portable nanobiosensor with machine learning: enabling multi-cytokines point-of-care testing and early identification of sepsis immunoparalysis

Abstract Sepsis immunoparalysis (SIs) is a major factor contributing to organ dysfunction. However, emergency departments (EDs) and intensive care units (ICUs) currently lack a rapid workflow for early identification of SIs. Herein, an innovative strategy for early SIs identifica...

Pan-genome-guided reverse vaccinology identifies a conserved lipoprotein-based multi-epitope vaccine candidate against Staphylococcus haemolyticus

Staphylococcus haemolyticus is an emerging opportunistic pathogen linked to bloodstream infections, device-associated infections, and other nosocomial complications, highlighting the need for alternative preventive measures. In this study, 36 complete S. haemolyticus genomes were...

A Multimodal large language model-based triage tool for osteoporotic vertebral compression fractures using posture and movement videos

Osteoporotic vertebral compression fracture (OVCF) is common yet frequently underdiagnosed due to nonspecific symptoms and limited access to definitive imaging. We developed a two-stage screening framework that integrates prompt-guided multimodal large language model (LLM) featur...

Integrative network toxicology and computational modeling uncover the mechanism of aflatoxin B1-induced nephrotoxicity

Aflatoxin B1 (AFB1) is a highly toxic mycotoxin that causes severe renal injury, yet the molecular basis of its nephrotoxicity remains poorly defined. Here, we integrated multi-omics data with computational modeling to elucidate the mechanisms of AFB1-induced kidney damage. Three...

Integrative network toxicology and transcriptomic analysis identifies candidate molecular links between drinking-water disinfection by-products and prostate cancer

Disinfection by-products (DBPs) are ubiquitous contaminants generated during drinking-water disinfection and have been associated with adverse health outcomes. Although epidemiological and toxicological studies have linked long-term DBP exposure to urinary tract malignancies, the...

The Impact of Rain classroom-based flipped classroom (RC-BFC) on surgical nursing education enhancement

Clinical nursing education is essential for facilitating students’ successful transition into professional practice. The Rain Classroom-based Flipped Classroom (RC-BFC) model represents an innovative teaching strategy that emphasizes active, student-centered learning through the...