Institution
Target (United States)
Recent research
- BiologyOpen access
Positive selection screen identifies natural product β-catenin inactivators
Many genetically validated targets in cancer, including the transcription factor β-catenin (β-cat), have historically been viewed as undruggable. Cell-based phenotypic screening of chemical compounds can reveal unanticipated biological and pharmacological principles. Natural prod...
- Engineering & Technology
Self-Aligned AlO x Spacer Enabling 10 nm-Scaled InZnSnO Thin-Film Transistors for 2T0C DRAM
Abstract Oxide semiconductors are promising for low-power dynamic random access memory (DRAM) due to their ultralow off-state leakage and back-end-of-line compatibility. Continued transistor scaling is essential to further enhance electrical performances, however, conventional li...
- Health & MedicineOpen access
Abstract The concept of anticoagulant-related nephropathy (ARN), first proposed in 2009, manifests as acute kidney injury or the rapid deterioration of chronic kidney disease secondary to anticoagulant therapy. Large numbers of tubular RBCs and/or tubular RBC casts and ATN, witho...
- Health & Medicine
A 54-year-old man with progressive small cell lung cancer underwent ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT before radionuclide therapy. ¹⁸F-FDG PET/CT evaluated disease extent and identified metabolically active lesions. ⁶⁸Ga-DOTATATE PET/CT showed high SSTR expression in bone lesions...
- BiologyOpen access
Finetuning Foundation Models for Temporal Clinical Transcriptomics Data
BACKGROUND: Timeseries clinical transcriptomic datasets offer the opportunity to gain insights into the dynamics of disease mechanisms/treatment responses. However, their utility in uncovering temporal patterns is often limited by high noise levels and small sample sizes. Leverag...
- Engineering & TechnologyOpen access
Porphyry systems are considered as low-grade, but high-tonnage, sources of scarce critical metals such as Cu and Mo, but they also host economic by-products of precious metals such as Au and Ag as well as rare trace critical metals such as Se, In, Te, and Re. The latter are of in...