ExMODE: A comprehensive resource for extremophile genomic and functional exploration
Abstract
ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat-specific non-redundant genes, 5.25 million representative protein structures, 67,026 metagenome-assembled genomes (MAGs), and 164,132 biosynthetic gene clusters (BGCs). By combining sequence-, structure-, and genome-based exploration across five extreme environments, it enables functional characterization of microbial dark matter through integrated comparative analyses and structure-guided searches. A cross-habitat microviridin case study demonstrates that ExMODE is an effective platform for discovering novel BGCs and biotechnologically valuable natural products.
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Authors: D Li, Kailong Ma, Xiaoqiang Li, Jieni Wang, Zhen Cui, Yulu Zhang, Weiwen Wang, Jiawei Tong, Yang Guo, Zongan Wang, Peiyun Zeng, Jieyu Wang, Xiaokai Xu, Nannan Zhang, Yingying Zhang, Jing Chen, Qingjiang Hu, Wenzhen Yang, Zhiyong Li, Tao Yang, Wensi Du, Zhicheng Xu, Zhen Yue, Jian Wang, Guangyi Fan, Weijia Zhang, Xun Xu, Liujie Huo, Xiaofeng Wei, Meng Liang, Shanshan Liu
Institutions: Chinese Academy of Sciences, Institute of Oceanology, Sanya University, Shandong University, State Key Laboratory of Microbial Technology, Institute of Deep-Sea Science and Engineering, BGI Research, BGI Group (China)