BGI Group (China)

Comparative Genomics Reveals Diversification and Chromosomal Organization of Putative Antimicrobial Peptide-Derived Sequences in Amphibious Mudskippers

Antimicrobial peptides (AMPs) and AMP-like fragments are important components of vertebrate innate immunity, but their genome-wide diversification in amphibious fishes remains unclear. Here, we performed integrated bioinformatics and comparative genomic analyses of three represen...

The comprehensive detection of hemoglobinopathy variants via long-read sequencing

ABSTRACT BACKGROUND The genetic complexity of hemoglobin genes, characterized by high GC content and homologous sequences, poses significant challenges for detecting hemoglobin variants in clinical settings. METHODS A long-read indexed PCR method utilizing the novel CycloneSEQ na...