Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions.
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Abstract
T cell infiltration and reduces T cell activation and proliferation; and iii) therapeutic strategies, including D-1MT, that improve intragranulomatous killing hold strong translational potential.
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Authors: Erin F McCaffrey, Alea Delmastro, Bindu Singh, Annu Devi, Caden W. Munson, Priyanka, Nadia A Golden, Shabaana A Khader, Michael Angelo, Deepak Kaushal, Smriti Mehra
Institutions: University of Chicago, Tulane University, Stanford University, National Institute of Allergy and Infectious Diseases, Texas Biomedical Research Institute