Tulane University

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...

Sex Differences in Acute Kidney Injury After Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock

Background: Sex-based differences in complications after venoarterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock are not well defined. We compared 30-day coded acute kidney injury and other short-term outcomes between female and male patients receiving EC...

Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions.

T cell infiltration and reduces T cell activation and proliferation; and iii) therapeutic strategies, including D-1MT, that improve intragranulomatous killing hold strong translational potential.

Maximum Likelihood Thresholds of Generic Linear Concentration Models

Abstract. The maximum likelihood threshold of a statistical model is the minimum number of datapoints required to fit the model via maximum likelihood estimation. In this paper, we determine the maximum likelihood thresholds of generic linear concentration models. This turns out...

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...

Anisotropic Electrostaticsin the Instability of GLP-1Analog Micelles: Effects of Electrolytes, Denaturants, pH, and Temperature

Abstract Glucagon-like peptide-1 (GLP-1) analogs (GLPA) exist primarily as micelle-like associations when free in aqueous solution. The results here indicate that anisotropic electrostatic interactions play a central role in the instability and aggregation, which appear to arise...

GRIMM-II: A two-stage real-time algorithm for nine-locus HLA imputation and matching with up to three mismatches

Background: The success of hematopoietic stem cell transplantation (HSCT) depends critically on human leukocyte antigen (HLA) matching between donor and recipient. While traditional matching focuses on five classical HLA loci (A, B, C, DRB1, DQB1), clinical practice increasingly...

It’s time to talk: exploring the role of couples' communication in improving health behaviors in Kebbi, Nigeria

In societies with strong patrilineal traditions, such as in northern Nigeria, husbands play the primary role in many household decisions, including for the reproductive health of their wives and the health of other family members. While previous research has shown that couples wh...

Extreme Risk Protection Order laws and fatal violence against women: a quasi-experimental study

Background Rates of intimate partner homicides of women in the USA are high relative to other high-income countries, especially those involving firearms. We evaluated one potential policy solution by examining state Extreme Risk Protection Order (ERPO) firearm transfer laws and i...

Diverse Edge andExcitonic States of Ta2Ni3Te5 Nanoribbonsand Monolayer: Implicationsfor Nanoelectronics

Abstract Ta2Ni3Te5, a layered transition-metal chalcogenide with quasi-one-dimensional electronic states, exhibits a rich variety of topological and correlation-driven phenomena. Using first-principles calculations, we investigate Ta2Ni3Te5 nanoribbons and demonstrate tunable ele...

Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles

During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report that conditional deletion of Mdm2, an E3...

CK2 targeting potentiates antineoplastic effects of dual HER2/EGFR inhibitor lapatinib and attenuates growth factor-induced epithelial-mesenchymal transition

CK2 is a pleiotropic, heterotetrameric kinase elevated in numerous cancers and, as such, has garnered much attention as a target for novel antineoplastic agents. Currently, silmitasertib, a selective CK2 inhibitor, has an orphan designation for medulloblastoma and neuroblastoma....

Optimizing Neurodevelopment in Infants With Severe Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is associated with multiple morbidities, including neurodevelopmental impairment. This association is multifactorial and further complicated by prolonged hospital stays during a critical period of rapid brain growth. Despite the well-established l...

Flumazenil Use in Benzodiazepine-Induced Delirium Reversal.

Delirium is a frequent and serious complication in critically ill patients, associated with increased mortality, prolonged hospitalization, and long-term cognitive impairment. The hypoactive subtype is particularly underrecognized, missed in up to 75% of cases, and carries worse...