Zhengzhou University

A multi-stage nonlinear relationship between artificial intelligence development and environmental pollution

Abstract As China advances its green and low carbon transition, the influence of artificial intelligence (AI) development on environmental pollution remains a critical yet underexplored issue; nevertheless, evidence on stage dependent effects beyond the conventional inverted U En...

Simulation of Discharge Evolution in the Main Streams of Large Rivers Using a Deep Learning Model: A Case Study of the Yellow River, China

Abstract Simulating river discharge evolution is fundamental to water resources management in large river basins. Nevertheless, human activities such as intensive water abstraction, reservoir operation, and other anthropogenic interventions have rendered the patterns of river dis...

Pulmonary embolism in lung cancer: a retrospective exploratory study

Lung cancer is associated with a high risk of venous thromboembolism, and pulmonary embolism (PE) is a critical complication. The synchronous diagnosis of PE at the initial presentation of lung cancer presents diagnostic challenges and affects management. The predictive factors f...

Nicotinamide Metabolism Constrains Memory CD8 + T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐bin...

Low-Oxygen and Dense Mo10Cr Alloys Prepared via In-Situ Nanocarbon Deoxygenation and Two-Step Pressurization Hot Pressing

Hot pressing is a promising technique for fabricating high-density molybdenum (Mo) alloys; however, obtaining low oxygen content remains a significant challenge. In this study, Mo10Cr alloy billets were prepared by hot pressing with nanocarbon addition and a two-step pressurizati...

Hippocampal Local Field Potentials Encode Continuous Flight Speed in Homing Pigeons via Complementary Gamma and Theta Signatures

Although the role of the mammalian hippocampus in representing locomotor speed has been widely investigated, how the avian hippocampus represents continuous flight speed under free-flight conditions in the outdoor environment remains unclear. In this study, we used homing pigeons...

Policy Pathways for Coordinated CO2 and Air Pollutant Reductions in Urban Road Transport: A Case Study of Zhengzhou, China

Urban road transport policies must simultaneously address climate mitigation, local air quality, and the infrastructure requirements associated with vehicle electrification. However, these dimensions are rarely evaluated within a unified city-level framework. This study develops...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Entertainment Sedentary Time and Subjective Well-Being in College Students: A Moderation Model of Perceived Time Poverty

This study examined the association between entertainment sedentary time (EST) and subjective well-being (SWB) among Chinese college students and further explored the moderating role of perceived time poverty (PTP). A total of 1582 college students completed questionnaires assess...

A One-Pot Reverse Transcriptase-Mediated, Pre-amplification-Free CRISPR/Cas12a Assay for Ultrasensitive Nucleic Acid Detection

Abstract CRISPR/Cas12a holds great promise for biosensing and diagnostics, but conventional methods suffer from low catalytic efficiency, high background, and reliance on pre-amplification. Direct detection of structured RNAs also remains challenging. Herein, we report the develo...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

Spin state and orbital engineering of cuprous oxide for efficient nitrate reduction

Abstract Electrocatalytic nitrate reduction provides a sustainable pathway for wastewater treatment and ammonia production, yet the complex multi‑electron transfer demands efficient catalysts to achieve both high selectivity and fast kinetics. Here we show that atomic substitutio...

Interface-shrunk regulated synthesis of asymmetric ultrafine mono-mesopore Nepenthes with tailored window

Asymmetric ultrafine mono-mesopore architectures with ultrasmall size, an open window, and unique physicochemical properties offer great opportunities in energy storage, yet their synthesis remains challenging. Inspired by the fast, unidirectional capture ability of Nepenthes, we...

Structural Designof AlGaN Deep-Ultraviolet Laserat Wavelength 266.3 nm with Graded Electron Blocking Layer and CompositeQuantum Wells/Barriers

Abstract Deep-ultraviolet laser diodes (DUV LDs) are developing as vigorous light sources for sterilization, lithography, purification, and biochemical sensing. However, the development of high-performance deep-UV laser diodes is still limited by poor hole injection, which comes...

Baicalin-Ternary LDH-Modified Magnesium Alloy with Anti-Corrosion and pH-Responsive Controlled Release, Near-Infrared-Enhanced Catalytic Property

Aiming at the rapid corrosion of degradable magnesium alloys in physiological environments and the insufficient long-term protection of single plasma electrolytic oxidation (PEO) coatings, Mg-Mn-Fe layered double hydroxide (LDH) and baicalin (BA)-loaded LDH/BA composite coatings...

Discovery ofa Potent APOBEC3B Inhibitor to AugmentAntitumor Immunity and Reduce Inflammatory Toxicity

Abstract APOBEC3B (A3B), a key driver of cancer mutagenesis, has emerged as a promising therapeutic target to be ablated to enhance antitumor immunity while reducing intestinal inflammation. Starting from SMC247 (3, 5-diiodotyrosine), a kelp-derived natural product, we identified...

Isotropic-carrier-transport perovskite single crystal enables high-photoresponsivity solar-blind photodetectors for selective flame monitoring

Low-dimensional halide perovskites are promising candidates for solar-blind ultraviolet photodetectors. However, simultaneously achieving high photoresponsivity and low dark current remains challenging, due to the restricted transport and collection of photogenerated carriers cau...

The SF3b complex in cancer: structural basis, molecular mechanisms, and therapeutic opportunities

Aberrant alternative splicing is increasingly recognized as a fundamental driver of cancer initiation and progression. The splicing factor 3b (SF3b) complex, an essential component of the U2 small nuclear ribonucleoprotein (snRNP), plays a pivotal role in branch point sequence (B...

In-Plane Shear Behavior of Masonry Walls Strengthened with High-Ductility Concrete and Steel Connectors

This study investigates the influence of high-ductility concrete (HDC) strengthening configurations and steel connector positions on the in-plane shear performance of masonry walls in a retrofit scenario where the external masonry facade is retained while the original masonry wal...