Xuzhou Medical College

Firmness Variation in Tomato Fruit: Driving Factors, Signaling Regulation, and Genetic Basis

Fruit firmness is a pivotal agronomic and commercial trait that determines the storability, transport tolerance and edible quality of tomato (Solanum lycopersicum L.). Fruit softening severely restricts postharvest performance and economic benefits of tomato products worldwide. T...

The genetic architecture of the CSF-contacting nucleus in mice and the screening of its key target via CSF pathway for mediating neuropathic pain

The cerebrospinal fluid (CSF)-contacting nucleus has been well characterized in rats and macaques but not yet precisely defined in mice. This study aims to provide a comprehensive description of the location, adjacent structures, cell morphology, spatial imaging, and genetic arch...

PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy

Although chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for relapsed/refractory multiple myeloma (RRMM), durable remission remains challenging. T-cell dysfunction and exhaustion are key obstacles to long-term efficacy. Programmed death-ligan...

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Breast cancer stemness drives tumor progression and therapy resistance, yet the underlying mechanisms remain poorly understood. In this study, we observed that RBM38 expression gradually decreases during breast cancer progression in MMTV - PyMT transgenic mice. Using a model with...

V-Shape Lumbar Bridge: postural reduction combined with percutaneous vertebroplasty for the treatment of osteoporotic compression fractures

The aim of the current study was to explore the surgical effect, imaging parameters and complications of “V-Shape Lumbar Bridge” postural reduction combined with percutaneous vertebroplasty strategy for treatment of osteoporotic vertebral compression fractures (OVCF) and severe o...

High-pitch Low-dose Chest Computed Tomography With Calcium-aware Reconstruction for Coronary Artery Calcium Scoring

PURPOSE: To evaluate the accuracy, radiation dose, and clinical feasibility of a high-pitch low-dose chest CT (Sa36LDCT) scanning protocol with calcium-aware reconstruction for coronary artery calcium scoring (CAC). MATERIALS AND METHODS: In this prospective study, 90 patients un...

A multi-database machine learning approach to predict depression and frailty in elderly populations with chronic conditions

Depression and frailty frequently co-occur in older adults with chronic disease, significantly impairing physical and psychological health; however, their bidirectional association remains unclear. Data from four large population-based cohorts—CHARLS, HRS, KLOSA, and SHARE—were c...

Hydraulic Mechanism and Flow Pattern Optimization of Special Orthogonal Lateral-Intake Pumping Stations in Coastal Hydraulic Hubs

Special orthogonal lateral-intake pumping stations on coastal plains face severe lateral deflection and recirculation in the approach channel and forebay. Their underlying evolutionary mechanisms remain unclear, and conventional rectification methods cause substantial hydraulic l...

An injectable collagen-silica tissue filler with collagen regeneration

Abstract Tissue filling represents an effective strategy for correcting facial contour irregularities and eliminating facial wrinkles. In recent years, silica-based biomaterials have emerged as promising candidates for the development of novel tissue fillers, owing to their super...

USP2 is associated with mitochondrial respiratory activity and cell viability in endometrial stromal cells in endometriosis

Mitochondrial dysfunction has been implicated in the pathophysiology of endometriosis, but the role of ubiquitin-specific protease 2 (USP2) remains unclear. This study aimed to determine whether USP2 modulates mitochondrial respiratory activity and proliferation in ectopic endome...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...

Nonlinear association between platelet distribution width and futile recanalization in acute ischemic stroke patients undergoing mechanical thrombectomy

Platelet distribution width (PDW) is increasingly recognized as a potential biomarker in cardiovascular and cerebrovascular diseases. We, therefore, sought to clarify whether baseline PDW values predict futile recanalization (FR) among acute ischemic stroke (AIS) patients receivi...

Histone Lactylation Mediated by circRNA-Facilitated FXR1 Phase Separation Promotes Colorectal Cancer Progression

Abstract Histone lactylation is an epigenetic modification triggered by lactate produced during glycolysis. In cancer, histone lactylation can coordinate metabolic and epigenetic states to promote tumor development and progression. Here, we identified circ2891 as a driver of meta...

Preoperative triglyceride–glucose index and 30-day surgical site infection in OSCC patients without documented diabetes: a retrospective cohort study

Surgical site infection (SSI) remains an important complication after oral squamous cell carcinoma (OSCC) surgery. Although diabetes is a recognized infection risk factor, metabolic vulnerability in patients without documented diabetes is less understood. The triglyceride–glucose...

Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants

2′,5’ oligoadenylate (2-5A) activates RNase L to degrade intracellular RNA and inhibit viral proliferation. The resulting nucleotide fragments bind RIG-I-like receptors to initiate type I interferon (IFN-I) signaling, enhancing maturation of antigen processing cells to trigger ad...

Effect of postpartum probiotic supplementation on breastmilk composition and infant health: a pilot randomized controlled trial

Breast milk is the optimal infant nutrition, and its composition is influenced by maternal factors including supplement intake. This study aimed to investigate the effects of postpartum probiotic supplementation on breast milk composition and infant health outcomes. This double-b...

Stress hyperglycaemic ratio is independently associated with intramyocardial haemorrhage in STEMI patients: a cardiac magnetic resonance study

ST-segment elevation myocardial infarction (STEMI) often results in microvascular injury, including intramyocardial haemorrhage (IMH), despite successful reperfusion. This study explored whether the stress hyperglycaemic ratio (SHR) is independently associated with IMH in STEMI p...

Quality of postoperative recovery in patients undergoing laparoscopic colorectal cancer resection as affected by transversus abdominis plane block combined with moderate neuromuscular blockade: a randomized controlled trial

Postoperative recovery quality in laparoscopic surgery may benefit from deep neuromuscular blockade, whereas the effects of combining transversus abdominis plane block (TAPB) with moderate neuromuscular blockade in this regard remain unreported. This work investigated whether mod...

Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer

Dual-target c-Met/VEGFR kinase inhibitors have emerged as promising therapeutic agents for cancer therapy, although their underlying antitumor mechanisms remain poorly defined. In this study, we demonstrate that foretinib, a selective c-Met/VEGFR2 inhibitor, triggers immunogenic...

Machine learning–guided identification of determinants of PD-L1 expression and tumor mutational burden in lung squamous cell carcinoma

Programmed death-ligand 1 (PD-L1) expression and tumor mutational burden (TMB) are widely used immunotherapy biomarkers, yet their variability and determinants in lung squamous cell carcinoma (LUSC) remain incompletely characterized in real-world testing settings. We analyzed a r...