Xuzhou Medical College

Batatasin III alleviates inflammatory bowel disease by suppressing MMP7 and NFκB signaling in macrophages and restoring gut microbial balance

Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation, disruption of the mucosal barrier, and immune dysregulation. Recent evidence underscores the role of gut macrophages, microbiota, and proinfla...

A syringe-based nanoliquid biopsy platform integrating magnetic immunocapture and electrochemical assay for circulating tumor cells enumeration and molecular profiling in NSCLC patients

The number and phenotypic profile of circulating tumor cells (CTCs) have demonstrated their capability in cancer diagnosis and therapeutic efficacy assessment, while programmed death-ligand 1 (PD-L1) and major histocompatibility complex class Ⅱ (MHC-Ⅱ) emerge as core predictive b...

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clin...

Waldenstrom’s macroglobulinemia in siblings: a single institutional experience with 10 cases at 25 years and a review of the literature

Waldenstrom’s macroglobulinemia (WM) is characterized by familial aggregation. The study displayed the characteristics and outcomes of patients with WM in siblings. Ten cases (five pairs) were recognized as WM in siblings. The earliest pair (cases 3 and 4) was identified in 2002...

Safety analysis of acyclovir use in neonates based on the FDA Adverse Event Reporting System

Acyclovir is the first-line treatment for neonatal herpes simplex virus infection; however, safety evidence in neonates remains limited. This study aimed to evaluate the safety profile of acyclovir in neonates using real-world pharmacovigilance data from the Food and Drug Adminis...

Alexithymia Profiles and Associated Factors Among Older Stroke Patients in China: A Latent Profile Analysis

OBJECTIVES: This study aimed to identify latent profiles of alexithymia among older stroke patients and examine factors associated with profile membership. METHODS: A cross-sectional survey was conducted among 286 older stroke patients in a tertiary hospital in Jilin Province, Ch...

Unicompartmental versus total knee arthroplasty in patients aged 60 years or older with isolated medial knee osteoarthritis and correctable varus deformity > 15° to 20°: a five-year retrospective cohort study

The role of unicompartmental knee arthroplasty (UKA) in patients aged ≥ 60 years with isolated medial knee osteoarthritis and correctable varus > 15° remains controversial. Five-year UKA and total knee arthroplasty (TKA) outcomes were compared in patients with varus > 15° to 20°....

A Validated, explainable machine learning–based preoperative risk model for microvascular invasion in hepatocellular carcinoma

Abstract Purpose This investigation aimed to develop and validate a diagnostic algorithm for preoperatively assessing the likelihood of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Methods Clinical and pathological information of patients with HCC...

Synergistic antitumor immune activation in melanoma using LA-PegPI polymeric gene vaccine in conjunction with PD-1 inhibition

Cancer gene vaccines are a promising avenue for cancer immunotherapy; however, their success depends not only on the gene construct itself but more critically on the efficacy and safety of the gene delivery vehicle. Targeting dendritic cells (DCs), the specialized antigen-present...

Factors associated with 30-day unplanned readmission after first-ever ischemic stroke: a retrospective cohort study in China

Unplanned readmission is an important post-stroke outcome, but clinically detailed data from Chinese cohorts remain limited. We evaluated the frequency of 30-day unplanned readmission after first-ever ischemic stroke and examined clinical factors associated with this outcome. We...

Prognostic factors influencing overall and cancer-specific survival in elderly patients with oral and maxillofacial squamous cell carcinoma

Abstract Background Oral and maxillofacial squamous cell carcinoma (OMSCC) is prevalent in the elderly, yet comprehensive prognostic analyses integrating host-related factors for this population are scarce. This study aimed to identify prognostic factors for overall survival (OS)...

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

Association between psychological frailty index and incident complete tooth loss among middle-aged and older adults: a prospective study based on CHARLS

Complete tooth loss is a severe oral health condition in middle-aged and older adults and is associated with impaired mastication, nutritional problems, reduced quality of life, and adverse ageing-related outcomes. Psychological frailty reflects multidimensional psychological vul...

A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice

Slow nasal breathing alleviates negative moods, but the precise nose-to-limbic pathways and their causal contributions remain unclear. Here, we identify a pathway in mice from olfactory sensory neurons (OSNs) in the nasal cavity to mitral cells in the olfactory bulb (OB), then to...

First-line sugemalimab plus chemotherapy for metastatic non-small-cell lung cancer: an updated cost-effectiveness analysis based on 4-year survival data

OBJECTIVE: Incorporating the 4‑year long‑term survival outcomes from the GEMSTONE‑302 trial, this study aimed to evaluate the cost‑effectiveness of sugemalimab plus chemotherapy versus chemotherapy alone as first‑line treatment for metastatic non‑small‑cell lung cancer (NSCLC) fr...

Sex differences in neurogenic hypertension: estrogen modulation of NADPH oxidase signaling in the rostral ventrolateral medulla

Abstract Neurogenic hypertension is characterized by sustained sympathetic activation arising from dysregulation within the central autonomic network. The rostral ventrolateral medulla (RVLM) is a major sympathetic premotor region that integrates reflex, neurohumoral, inflammator...

A quantitative and visual detection probe based on isothermal nucleic acid amplification coupled with CRISPR/Cas12a system (INACS) for miR155 detection

MicroRNAs (miRNAs) have emerged as ideal biomarkers for early clinical diagnosis. Achieving the accurate detection of miRNAs plays a critical role for assuring its implementation in their clinical applications. In this study, we developed a dual-signal amplified ultrasensitive fl...

Non-HDL-C to HDL-C ratio and risks of all-cause and cardiovascular mortality in patients with coronary heart disease and type 2 diabetes mellitus

Dyslipidemia is a major contributor to adverse outcomes in patients with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a comprehensive lipid marker, but its pr...

Temporal Profiles and Clinical Associations of Lipoprotein and Apolipoprotein Profiles in Critically Ill Patients with Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PIICS): A Retrospective Cohort Study

Persistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is a severe complication in critically ill patients, accompanied by profound disturbances in lipid metabolism. However, the sequential changes in these lipoproteins and apolipoproteins and their associati...

TargetingArginine Metabolism via ArcR: BlestriareneB Suppresses Staphylococcus aureus BiofilmFormation and Cellular ATP Production

Abstract Blestriarene B (BB), a biphenanthrene compound isolated from the medicinal plant Bletilla striata, possesses antibacterial properties against Staphylococcus aureus; however, its molecular target and underlying mechanisms remain unclear. Arginine metabolism plays a pivota...