Xuzhou Medical College

Nonlinear association between platelet distribution width and futile recanalization in acute ischemic stroke patients undergoing mechanical thrombectomy

Platelet distribution width (PDW) is increasingly recognized as a potential biomarker in cardiovascular and cerebrovascular diseases. We, therefore, sought to clarify whether baseline PDW values predict futile recanalization (FR) among acute ischemic stroke (AIS) patients receivi...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...

Histone Lactylation Mediated by circRNA-Facilitated FXR1 Phase Separation Promotes Colorectal Cancer Progression

Abstract Histone lactylation is an epigenetic modification triggered by lactate produced during glycolysis. In cancer, histone lactylation can coordinate metabolic and epigenetic states to promote tumor development and progression. Here, we identified circ2891 as a driver of meta...

Preoperative triglyceride–glucose index and 30-day surgical site infection in OSCC patients without documented diabetes: a retrospective cohort study

Surgical site infection (SSI) remains an important complication after oral squamous cell carcinoma (OSCC) surgery. Although diabetes is a recognized infection risk factor, metabolic vulnerability in patients without documented diabetes is less understood. The triglyceride–glucose...

Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants

2′,5’ oligoadenylate (2-5A) activates RNase L to degrade intracellular RNA and inhibit viral proliferation. The resulting nucleotide fragments bind RIG-I-like receptors to initiate type I interferon (IFN-I) signaling, enhancing maturation of antigen processing cells to trigger ad...

Stress hyperglycaemic ratio is independently associated with intramyocardial haemorrhage in STEMI patients: a cardiac magnetic resonance study

ST-segment elevation myocardial infarction (STEMI) often results in microvascular injury, including intramyocardial haemorrhage (IMH), despite successful reperfusion. This study explored whether the stress hyperglycaemic ratio (SHR) is independently associated with IMH in STEMI p...

Effect of postpartum probiotic supplementation on breastmilk composition and infant health: a pilot randomized controlled trial

Breast milk is the optimal infant nutrition, and its composition is influenced by maternal factors including supplement intake. This study aimed to investigate the effects of postpartum probiotic supplementation on breast milk composition and infant health outcomes. This double-b...

Quality of postoperative recovery in patients undergoing laparoscopic colorectal cancer resection as affected by transversus abdominis plane block combined with moderate neuromuscular blockade: a randomized controlled trial

Postoperative recovery quality in laparoscopic surgery may benefit from deep neuromuscular blockade, whereas the effects of combining transversus abdominis plane block (TAPB) with moderate neuromuscular blockade in this regard remain unreported. This work investigated whether mod...

Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer

Dual-target c-Met/VEGFR kinase inhibitors have emerged as promising therapeutic agents for cancer therapy, although their underlying antitumor mechanisms remain poorly defined. In this study, we demonstrate that foretinib, a selective c-Met/VEGFR2 inhibitor, triggers immunogenic...

Machine learning–guided identification of determinants of PD-L1 expression and tumor mutational burden in lung squamous cell carcinoma

Programmed death-ligand 1 (PD-L1) expression and tumor mutational burden (TMB) are widely used immunotherapy biomarkers, yet their variability and determinants in lung squamous cell carcinoma (LUSC) remain incompletely characterized in real-world testing settings. We analyzed a r...