Xuzhou Medical College

Macrophage-mimetic liposomal nanovesicles deliver CXCR2 antagonists to suppress CXCL2-driven breast cancer and atherosclerotic progression

The coexistence of breast cancer (BC) and atherosclerosis (AS) is increasingly recognized as an inflammation-driven comorbidity. This study identifies the CXCL2–CXCR2 signaling axis as a pivotal mechanistic link underlying both diseases and introduces a macrophage-mimetic nanopla...

Effect of transcutaneous auricular vagus nerve stimulation on postoperative gastrointestinal dysfunction in patients with gynecological abdominal or pelvic tumors: a study protocol for a prospective, single-center, randomized, controlled clinical trial

BACKGROUND: Postoperative gastrointestinal dysfunction (POGD) commonly presents with nausea, vomiting, abdominal distension, delayed flatus or stool, and prolonged intolerance to oral intake. It can cause postoperative pain, delayed gastrointestinal motility, or intestinal obstru...

Low education and incident complete tooth loss: cross-national associations and cohort-specific mediation pathways in HRS and CLHLS

Low educational attainment reflects accumulated socioeconomic disadvantage and may contribute to severe oral health inequalities across the life course. Whether its association with incident complete tooth loss is consistent across populations with different social and behavioral...

Exploratory single-nucleus transcriptomic analysis of endothelial heterogeneity and ferroptosis-related gene patterns in a human hepatocellular carcinoma sample

Background Endothelial heterogeneity may contribute to vascular remodeling in hepatocellular carcinoma (HCC), while ferroptosis-related iron handling intersects with hypoxic, inflammatory, and metabolic stress. We therefore characterized endothelial transcriptional states in a pu...

A study on the impact of productive social participation on depression among older adults in China

As the ageing of China’s population continues to accelerate, mental health issues among older adults are increasingly becoming a key concern in public health, social governance and the development of elderly care service systems. Against the backdrop of the deepening concepts of...

Prediction of the Efficacy of PA-TACE in Patients with Clearly Defined Hepatocellular Carcinoma by Imaging Combined with Serology: A Retrospective Cohort Study with a Two-Center Follow-Up of up to 12 Years

Objective: The purpose of this study was to determine which patients with hepatocellular carcinoma (HCC) actually benefit from Postoperative adjuvant Transarterial chemoembolization (PA-TACE) and to develop a reliable predictive model for tailored treatment choices. Methods: A to...

Application effect of PBL combined with skeletal simulation-based surgical training teaching mode in orthopedic teaching

Orthopedics is a highly practical clinical discipline, and traditional single problem-based learning (PBL) teaching is limited by the lack of intuitive operational training, which easily leads to the disconnection between theoretical learning and clinical practice in medical stud...

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in elderly patients undergoing non-cardiac and non-neurosurgical procedures: protocol for a multicentre, double-blind, randomized, controlled trial

BACKGROUND: Whether ephedrine, when used to maintain intraoperative blood pressure, is superior to phenylephrine in reducing postoperative delirium remains uncertain. This study aims to determine whether the intraoperative management of hypotension with ephedrine, compared with p...

Perioperative non-invasive neuromodulation for delirium and cognitive recovery: from preclinical evidence to clinical translation

Perioperative neurocognitive disorders (PND) are a challenge for patients to accelerate postoperative recovery, and exploring more effective interventions can help reduce long-term cognitive dysfunction. Non-invasive neuromodulation (NIN) has shown potential in improving postoper...

Diagnostic performance of ultrasound-measured visceral fat thickness and metabolic indices for MRI-PDFF-defined hepatic steatosis in MAFLD

Metabolic dysfunction-associated fatty liver disease(MAFLD) has emerged as a globally significant liver disorder due to its continuously rising prevalence. Our aim is to investigate the clinical value of ultrasound-measured visceral fat thickness (VFT) and five scoring systems—fa...

Mendelian randomization analysis of causal associations between immune cell subsets and stroke and glioma risk with fine-mapping of candidate genes

Post-operative cerebral infarction represents a severe complication following glioma surgery, yet the molecular mechanisms underlying this association and its potential relationship with tumorigenesis remain unclear. This study aims to explore the molecular connections between ce...

New-onset headache and early aggravation of pre-existing headache after anterior cervical discectomy and fusion: a retrospective cohort study

Pre-existing cervicogenic headache often improves after anterior cervical discectomy and fusion (ACDF); however, new-onset postoperative headache and early aggravation of pre-existing headache remain poorly characterized. This study evaluated these outcomes separately and assesse...

Insight impairment mediates the effect of SOX2-OT polymorphism on antipsychotic response in first-episode schizophrenia

Insight impairment is a core clinical feature of schizophrenia that predicts poor treatment adherence and unfavorable prognosis. Genetic factors have been increasingly recognized as a likely basis for inter-individual variability in insight; however, direct evidence for a complet...

Surgical outcomes and prognostic factors in elderly Chinese patients with valvular heart disease: a multi-center retrospective cohort study

Abstract Objective To investigate surgical outcomes and prognostic factors in elderly patients (≥ 60 years) with valvular heart disease (VHD) undergoing surgery, and to provide evidence for optimizing clinical decision-making. Methods A retrospective analysis was conducted on 347...

Rota–Baxter Operators and Systems on Hom-π-Algebras: Constructions, Derivation Chains, and Structural Equivalence

(1) Background: Hom-type algebras, proposed by Yau, generalize classical algebras via twisting maps. Dendriform and tridendriform algebras, introduced by Loday and Vallette, decompose associative multiplications and play significant roles in algebraic K-theory and operad theory....

Comparative influence of opioid-free versus opioid-containing anesthetic techniques upon Th1/Th2 balance during laparoscopic colorectal cancer procedures: a randomized controlled trial

Abstract Background Surgical resection is central to colorectal cancer management, but surgery and anesthesia can induce perioperative immunosuppression. Opioids, a mainstay of perioperative analgesia, may impair cellular immunity, including disruption of Th1/Th2 immune equilibri...

Band-like marginal gingival necrosis as the initial manifestation of acute monocytic leukemia: a case report

Oral manifestations may precede the diagnosis of acute myeloid leukemia (AML), particularly in monocytic subtypes, but the typical findings are gingival enlargement, spontaneous bleeding, petechiae, or nonspecific ulceration. Band-like necrosis confined to the gingival margins an...

The cerebrospinal fluid-contacting nucleus CGRP-RAMP1-PKA signaling pathway mediates trigeminal neuralgia and its mechanism

Background: Trigeminal neuralgia (TN) is prevalent form of neuropathic pain (NP). Its regulatory circuits and mechanisms remain unclear. The authors' previous work demonstrated that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) participates in the regulation...

Methyl indole-3-acetate mediates myricetin-induced brown adipose tissue activation and reproductive-metabolic improvement in PCOS mice

Abstract Polycystic ovary syndrome (PCOS) is frequently associated with alterations in gut microbiota composition, although the specific microbial metabolites that influence ovarian function remain incompletely understood. Myricetin has been reported to improve reproductive and m...