Xuzhou Medical College

Development of pathology-responsive Cu-based metal–phenolic nanonetworks for disease-modifying treatment of knee osteoarthritis

Objectives Knee osteoarthritis (KOA) is characterized by chronic inflammation, oxidative stress, and extracellular matrix (ECM) degradation, while current therapies mainly provide symptomatic relief. We developed a pathology-responsive copper-based metal-phenolic nanonetwork (Cu-...

Diverse patterns of transcriptional regulation and epigenetic reprogramming within PMDs contribute to ESCC progression by regulating EMT and immunosuppression

Partially methylated domains (PMDs) represent extensive genome-wide hypomethylated regions that drive genomic instability and proto-oncogene activation. However, their complex regulatory influence on tumor-specific transcriptional networks remains largely elusive. In this study,...

The CARM1–YIPF2 axis drives breast cancer progression and predicts poor prognosis

Objective To investigate the roles of CARM1 and its regulatory effect on YIPF2 in breast cancer progression. Methods Breast cancer cells were transfected with CARM1 siRNA to knock down CARM1 expression. Cell proliferation, apoptosis, migration, and invasion were assessed using Ed...

Cooperative Dual‐Directional π – π Stacking in Self‐Assembled Monolayers for High‐Performance Inverted Perovskite Solar Cells

ABSTRACT The evolution from monomeric to dimeric self‐assembled monolayers (SAMs) opens new opportunities for inverted perovskite solar cells (PSCs), yet stronger π – π interactions in these larger architectures risk inducing aggregation over ordered assembly, making it challengi...

Association between coffee consumption and oral and pharyngeal cancers: a systematic review and meta-analysis

Oral and pharyngeal cancers are major contributors to global cancer-related morbidity and mortality, particularly in regions with high prevalence of tobacco, alcohol, and chewing-related exposures. Caffeine-containing beverages such as coffee and tea may influence carcinogenesis...

Infection of macrophages by mpox virus activates inflammasome and cell death, informing multitarget therapeutic strategies

Severe mpox virus (MPXV) infection causes immunopathological manifestations in patients. Here, we provide clinical evidence of MPXV-induced inflammation in a large patient cohort and demonstrate direct macrophage infection in skin tissues from an autopsied mpox patient. In human...

HTR1D triggers osteosarcoma metastasis and doxorubicin resistance via c-MYC/MAPK feedback and CCL2/5-HT-mediated M2 polarization

Osteosarcoma (OS) treatment remains hindered by frequent metastasis and resistance to doxorubicin, the standard chemotherapeutic. Despite multimodal therapy, survival for advanced disease is dismal. Identifying molecular drivers that concurrently regulate invasion and chemoresist...

Targeting the ENO1 metabolic checkpoint via microenvironment-responsive nanotherapeutics promotes postinfarction cardiac repair

Myocardial infarction (MI) triggers persistent inflammatory dysregulation, wherein macrophages undergo glycolytic reprogramming and adopt an inflammatory phenotype that impairs cardiac repair. However, the specific metabolic drivers underlying post-MI macrophage dysfunction remai...

Living environmental quality and incident depressive symptoms among middle-aged and older adults in China: a national longitudinal study

Depressive symptoms are common in mid-to-late adulthood in China. Evidence linking living environments to depression has often focused on single exposures, and prospective evidence on the association between an integrated measure of living environmental quality (LEQ) and subseque...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Capital Flight and Regional Divergence in a Spatial Model of Financial Contagion

ABSTRACT This paper investigates a reaction–diffusion–chemotaxis model describing the interaction between financial instability and spatial economic differentiation. The model incorporates a herding mechanism that amplifies speculative behavior and a chemotactic flux representing...

Active-passive hybrid broadband vibration control based on maple-leaf-inspired biomimetic structures

Broadband vibration control remains a critical challenge in lightweight structural design. This study proposes a bio-inspired integrated approach combining a maple-leaf-inspired laminated structure with active-passive hybrid control to achieve effective vibration suppression acro...

Distinct functional brain network alterations associated with 5-fluorouracil- and carboplatin-based chemotherapy regimens in CRC and NSCLC patients: a combined graph theory and group ICA study based on rs-fMRI

It is not yet clear whether there are differences in the impact of different chemotherapy regimens on brain function. Especially, the distinct brain network alterations between patients underwent different regimens are still unclear. This study aimed to explore regimen-associated...

Large language model–assisted scoring of physician-administered parent interviews for autism screening in young children: a retrospective diagnostic case-control and agreement study

Large language models (LLMs) may assist clinicians in scoring narrative parent-report interviews, but diagnostic discrimination, score agreement, output repeatability, and clinical utility are distinct claims. We evaluated an LLM-assisted workflow for scoring a physician-administ...

Medical disputes and turnover intention among physicians and medical technicians: evidence from a cross-sectional study in Xuzhou, China

Physicians and medical technicians’ turnover intention (TI) poses a growing threat to healthcare workforce stability. Medical disputes are increasingly recognized as a salient occupational stressor, however, their adjusted association with TI remains unclear. This study aimed to...

Neutrophil to lymphocyte ratio at stoma site predicts colorectal cancer prognosis

This research examines the connection between the neutrophil-to-lymphocyte ratio (NLR) observed at the stoma site and the prognostic outcomes in patients with colorectal cancer, in comparison to individuals without cancer. By conducting a retrospective analysis of clinical record...

Hypoxia down-regulates METTL3 and WTAP activating Integrin/FAK signaling through m6A/IGF2BP3 dependent manners in TGFBI mRNA to promote pancreatic neuroendocrine neoplasms progression

Hypoxia along with N6-methyladenosine (m6A) plays crucial roles in human tumorigenesis by influencing nearly every aspect of RNA metabolism. Nevertheless, the physiological signals that regulate the equilibrium between methylation and demethylation under hypoxic conditions have y...

Performance study of a DC electronic voltage transformer with passive temperature error correction capability

Purpose This study aims to address the temperature-dependent error of the primary voltage divider (PVD) in direct current electronic voltage transformers (DC-EVT). Taking full advantage of the superior properties of optical fiber sensors such as passivity, light weight and excell...

Incidence, prevalence and outcomes of neonatal sepsis: a population-based cohort study of hospitalized neonates in Huai’an, China

Background This study aims to estimate the incidence, prevalence of morbidity and mortality rate (MR), associated risks, and the applicability of neonatal sequential organ failure assessment (nSOFA), of neonatal sepsis from a database of all hospitalized infants in a representati...

Association Between Air Pollution and Psoriasis-Related Outcomes: A Systematic Review and Meta-analysis

Skin diseases are a group of consequences due to exposure to air pollution that have received less attention. Among these diseases, the relationships between short-term and long-term exposure to air pollutants and psoriasis remain uncertain. The present systematic review and meta...