Xuzhou Medical College

Prognostic factors influencing overall and cancer-specific survival in elderly patients with oral and maxillofacial squamous cell carcinoma

Abstract Background Oral and maxillofacial squamous cell carcinoma (OMSCC) is prevalent in the elderly, yet comprehensive prognostic analyses integrating host-related factors for this population are scarce. This study aimed to identify prognostic factors for overall survival (OS)...

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice

Slow nasal breathing alleviates negative moods, but the precise nose-to-limbic pathways and their causal contributions remain unclear. Here, we identify a pathway in mice from olfactory sensory neurons (OSNs) in the nasal cavity to mitral cells in the olfactory bulb (OB), then to...

Association between psychological frailty index and incident complete tooth loss among middle-aged and older adults: a prospective study based on CHARLS

Complete tooth loss is a severe oral health condition in middle-aged and older adults and is associated with impaired mastication, nutritional problems, reduced quality of life, and adverse ageing-related outcomes. Psychological frailty reflects multidimensional psychological vul...

First-line sugemalimab plus chemotherapy for metastatic non-small-cell lung cancer: an updated cost-effectiveness analysis based on 4-year survival data

OBJECTIVE: Incorporating the 4‑year long‑term survival outcomes from the GEMSTONE‑302 trial, this study aimed to evaluate the cost‑effectiveness of sugemalimab plus chemotherapy versus chemotherapy alone as first‑line treatment for metastatic non‑small‑cell lung cancer (NSCLC) fr...

Sex differences in neurogenic hypertension: estrogen modulation of NADPH oxidase signaling in the rostral ventrolateral medulla

Abstract Neurogenic hypertension is characterized by sustained sympathetic activation arising from dysregulation within the central autonomic network. The rostral ventrolateral medulla (RVLM) is a major sympathetic premotor region that integrates reflex, neurohumoral, inflammator...

Non-HDL-C to HDL-C ratio and risks of all-cause and cardiovascular mortality in patients with coronary heart disease and type 2 diabetes mellitus

Dyslipidemia is a major contributor to adverse outcomes in patients with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a comprehensive lipid marker, but its pr...

A quantitative and visual detection probe based on isothermal nucleic acid amplification coupled with CRISPR/Cas12a system (INACS) for miR155 detection

MicroRNAs (miRNAs) have emerged as ideal biomarkers for early clinical diagnosis. Achieving the accurate detection of miRNAs plays a critical role for assuring its implementation in their clinical applications. In this study, we developed a dual-signal amplified ultrasensitive fl...

Temporal Profiles and Clinical Associations of Lipoprotein and Apolipoprotein Profiles in Critically Ill Patients with Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PIICS): A Retrospective Cohort Study

Persistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is a severe complication in critically ill patients, accompanied by profound disturbances in lipid metabolism. However, the sequential changes in these lipoproteins and apolipoproteins and their associati...

TargetingArginine Metabolism via ArcR: BlestriareneB Suppresses Staphylococcus aureus BiofilmFormation and Cellular ATP Production

Abstract Blestriarene B (BB), a biphenanthrene compound isolated from the medicinal plant Bletilla striata, possesses antibacterial properties against Staphylococcus aureus; however, its molecular target and underlying mechanisms remain unclear. Arginine metabolism plays a pivota...

The genetic architecture of the CSF-contacting nucleus in mice and the screening of its key target via CSF pathway for mediating neuropathic pain

The cerebrospinal fluid (CSF)-contacting nucleus has been well characterized in rats and macaques but not yet precisely defined in mice. This study aims to provide a comprehensive description of the location, adjacent structures, cell morphology, spatial imaging, and genetic arch...

Firmness Variation in Tomato Fruit: Driving Factors, Signaling Regulation, and Genetic Basis

Fruit firmness is a pivotal agronomic and commercial trait that determines the storability, transport tolerance and edible quality of tomato (Solanum lycopersicum L.). Fruit softening severely restricts postharvest performance and economic benefits of tomato products worldwide. T...

PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy

Although chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for relapsed/refractory multiple myeloma (RRMM), durable remission remains challenging. T-cell dysfunction and exhaustion are key obstacles to long-term efficacy. Programmed death-ligan...

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Breast cancer stemness drives tumor progression and therapy resistance, yet the underlying mechanisms remain poorly understood. In this study, we observed that RBM38 expression gradually decreases during breast cancer progression in MMTV - PyMT transgenic mice. Using a model with...

High-pitch Low-dose Chest Computed Tomography With Calcium-aware Reconstruction for Coronary Artery Calcium Scoring

PURPOSE: To evaluate the accuracy, radiation dose, and clinical feasibility of a high-pitch low-dose chest CT (Sa36LDCT) scanning protocol with calcium-aware reconstruction for coronary artery calcium scoring (CAC). MATERIALS AND METHODS: In this prospective study, 90 patients un...

V-Shape Lumbar Bridge: postural reduction combined with percutaneous vertebroplasty for the treatment of osteoporotic compression fractures

The aim of the current study was to explore the surgical effect, imaging parameters and complications of “V-Shape Lumbar Bridge” postural reduction combined with percutaneous vertebroplasty strategy for treatment of osteoporotic vertebral compression fractures (OVCF) and severe o...

A multi-database machine learning approach to predict depression and frailty in elderly populations with chronic conditions

Depression and frailty frequently co-occur in older adults with chronic disease, significantly impairing physical and psychological health; however, their bidirectional association remains unclear. Data from four large population-based cohorts—CHARLS, HRS, KLOSA, and SHARE—were c...

Hydraulic Mechanism and Flow Pattern Optimization of Special Orthogonal Lateral-Intake Pumping Stations in Coastal Hydraulic Hubs

Special orthogonal lateral-intake pumping stations on coastal plains face severe lateral deflection and recirculation in the approach channel and forebay. Their underlying evolutionary mechanisms remain unclear, and conventional rectification methods cause substantial hydraulic l...

An injectable collagen-silica tissue filler with collagen regeneration

Abstract Tissue filling represents an effective strategy for correcting facial contour irregularities and eliminating facial wrinkles. In recent years, silica-based biomaterials have emerged as promising candidates for the development of novel tissue fillers, owing to their super...

USP2 is associated with mitochondrial respiratory activity and cell viability in endometrial stromal cells in endometriosis

Mitochondrial dysfunction has been implicated in the pathophysiology of endometriosis, but the role of ubiquitin-specific protease 2 (USP2) remains unclear. This study aimed to determine whether USP2 modulates mitochondrial respiratory activity and proliferation in ectopic endome...